Explicit formula of radiation fields of free waves with applications on channel of energy

In this work we give a few explicit formulas regarding the radiation fields of linear free waves. We then apply these formulas on the channel of energy theory. We characterize all the radial weakly non-radiative solutions in all dimensions and give a few new exterior energy estimates.Comment: 26 pages, 1 figur

LBH589 Inhibits proliferation and metastasis of hepatocellular carcinoma via inhibition of gankyrin/stat3/akt pathway

Background: Gankyrin has shown to be overexpressed in human liver cancers and plays a complex role in hepatocarcinogenesis. Panobinostat (LBH589), a new hydroxamic acid-derived histone deacetylase inhibitor has shown promising anticancer effects recently. Here, we investigated the potential of LBH589 as a form of treatment for hepatocellular carcinoma (HCC). Methods: Gankyrin plasmid was transfected into HCC cells, and the cells were selected for more than 4 weeks by incubation with G418 for overexpression clones. The therapeutic effects of LBH589 were evaluated in vitro and in vivo. Cell proliferation, apoptosis, cell cycle, invasive potential, and epithelial-mesenchy-mal transition (EMT) were examined. Results: LBH589 significantly inhibited HCC growth and metastasis in vitro and in vivo. Western blotting analysis indicated that LBH589 could decrease the expression of gankyrin and subsequently reduced serine-phosphorylated Akt and tyrosine-phosphorylated STAT3 expression although the total Akt and STAT3 were unaffected. LBH589 inhibited metastasis in vitro via down-regulation of N-cadherin, vimentin, TWIST1, VEGF and up-regulation of E-cadherin. LBH589 also induced apoptosis and G1 phase arrest in HCC cell lines. Ectopic expression of gankyrin attenuated the effects of LBH589, which indicates that gankyrin might play an important role in LBH589 mediated anticancer effects. Lastly, in vivo study indicated that LBH589 inhibited tumor growth and metastasis, without discernable adverse effects comparing to control group, with abrogating gankyrin/STAT3/Akt pathway. Conclusions: Our results suggested that LBH589 could inhibit HCC growth and metastasis through down-regulating gankyrin/STAT3/Akt pathway. LBH589 may present itself as a novel therapeutic strategy for HCC

Realizing Saturable Absorption and Reverse Saturable Absorption in a PEDOT:PSS Film via Electrical Modulation

Electrical tuning of the nonlinear absorption of materials has promising application potential, while studies remain rare. In this work, we show that the third-order nonlinear absorption of poly(3,4-ethylenedioxythiophene) chemically doped with poly(styrene sulfonic acid) [PEDOT:PSS] can be effectively modulated by external voltage. The nonlinear absorption of the film can be varied between reverse saturable absorption (RSA) and saturable absorption (SA) via voltage control with laser excitation at 800 nm, and the corresponding nonlinear absorption coefficient can be tuned in the range -1606 +- 73 to 521 +- 9 cm GW-1. The doping level and energy structure of PEDOT are modulated with different voltages. The undoped film affords two-photon absorption and accordingly the RSA response. A moderately doped sample has two polaron levels, and Pauli blocking associated with these two polaron levels results in SA. The bipolaron level in heavily doped PEDOT leads to excited-state absorption and therefore RSA behavior. The approach reported here can be applied to other semiconductors and is a convenient, effective, and promising method for the electrical tuning of the optical nonlinearity.DP17010041

Electrical Tuning of the Fifth‐Order Optical Nonlinearity of Antimony‐Doped Tin Oxide

In this work, the electrical tuning of the fifth-order nonlinear absorption of antimony-doped tin oxide (ATO) by ionic liquid gating is demonstrated. The pristine ATO film exhibits two-photon-induced excited-state absorption (2PA-ESA) with laser excitation at 1030 nm. The fifth-order nonlinear absorption coefficient (γeff) of the ATO film can be monotonically modified in the range of 0.51 to 3.46 cm3 GW−2 by varying the sample bias, with a maximum enhancement factor of 6.8. The fundamental processes occurring during electrical tuning are revealed. The electrostatic and electrochemical capacitance is responsible for the modification in the number of free carriers in the conduction band of ATO. The electrical modulation of the nonlinear absorption of the ATO is ascribed to the voltage-dependent diameter of the undepleted core of ATO. A smaller voltage results in the charging of ATO and a larger undepleted core, and consequently the size of the active component for 2PA-ESA is larger. The electrochemical capacitance results from the chemisorption of H+ and OH− on the surface of the ATO, the larger water content in the ionic liquid affording a larger modulation range for the number of free carriers and the γeff.DP17010041

The Impact of Cross-linking Mode on the Physical and Antimicrobial Properties of a Chitosan/Bacterial Cellulose Composite

The bacteriostatic performance of a chitosan film is closely related to its ionic and physical properties, which are significantly influenced by the mode of cross-linking. In the current work, chitosan with or without bacterial cellulose was cross-linked with borate, tripolyphosphate, or the mixture of borate and tripolyphosphate, and the composite films were obtained by a casting of dispersion. Mechanical measurements indicated that different modes of cross-linking led to varying degrees of film strength and elongation increases, while the films treated with the borate and tripolyphosphate mixture showed the best performance. Meanwhile, changes in the fractured sectional images showed a densified texture induced by cross-linkers, especially for the borate and tripolyphosphate mixture. Measurements of Fourier transform infrared showed the enhanced interaction between the matrix polymers treated by borate, confirmed by a slight increase in the glass transitional temperature and a higher surface hydrophobicity. However, the reduced antimicrobial efficiency of composite films against E. coli, B. cinerea, and S. cerevisiae was obtained in cross-linked films compared with chitosan/bacterial cellulose films, indicating that the impact on the antimicrobial function of chitosan is a noteworthy issue for cross-linking

Hip arthroscopy for femoroacetabular impingement: proceed with caution

In the UK FASHIoN trial, the investigators, comparing hip arthroscopy with a conservative rehabilitation program for the femoroacetabular impingement (FAI) treatment, reported better patient-assessed function 12 months following surgery than rehabilitation. However, due to lacking of evidence-based general consensus for diagnosis of FAI, the results of this study should be interpreted with caution. This commentary highlights the precautious attention required for the rapid growth of hip arthroscopy in terms of both indications and utilization and calls for more basic science studies and long-term prospective trials with proper indications and validated criteria to closely compare hip arthroscopy with non-surgical attempts

Enantioselective phase-transfer catalyzed alkylation of 1-methyl-7-methoxy-2-tetralone: an effective route to dezocine

In order to prepare asymmetrically (R)-(+)-1-(5-bromopentyl)-1-methyl-7-methoxy-2-tetralone (3a), a key intermediate of dezocine, 17 cinchona alkaloid-derived catalysts were prepared and screened for the enantioselective alkylation of 1-methyl-7-methoxy-2-tetralone with 1,5-dibromopentane, and the best catalyst (C7) was identified. In addition, optimizations of the alkylation were carried out so that the process became practical and effective

Multiscale assessment of the spatiotemporal coupling relationship between urbanization and ecosystem service value along an urban–rural gradient:A case study of the Yangtze River Delta urban agglomeration, China

Evolutions in land use in urban areas exert a growing influence on ecosystem service value (ESV). As a manifestation of spatial arrangement in mature urban growth, the ecological challenges within urban agglomerations and their surroundings deserve attention. Therefore, clarifying the interrelation within the ESV and urbanization is crucial to constructing sustainable progress-oriented cities. Previous researches on the coordination relationship between ESV and urbanization have been limited to the provincial and county levels, and insufficient consideration has been given to the differences across urban and rural areas at different scales. Utilizing the coupling coordination degree (CCD) model, the present investigation assesses the interplay between urbanization and ESV across various scales within the Yangtze River Delta urban agglomeration (YRDUA) region from 2000 to 2020, and explores the differences in their distributions throughout the urban–rural gradient, aiming to help the regional coordinated development. The findings indicate that from 2000 to 2010, with increasing intensity of land use, the ESV in YRDUA area decreased. But between 2010 and 2020, ESV increased. Moreover, the CCD in the YRDUA has a positive relationship across ESV and urbanization, and is in a status of primary coordination from 2000 to 2020, with a slow upward trajectory. Meanwhile, along the rural–urban gradient, ESV and CCD both are declining, and there is a significant plunge from suburban to urban. And the interactions between ESV and urbanization have obvious spatial heterogeneity, which tends to show the coordination at broader scales, such as provincial and county levels, while manifesting conflicts at finer scales, such as the grid scale. Our findings can help city planners and policy makers to minimize the adverse effects of urbanization sprawl on ecosystem services