1 research outputs found
Salivary Metabolite Fingerprint of Type 1 Diabetes in Young Children
Metabolomics
is an important tool for the evaluation of the human
condition, in both health or disease. This study analyzed the salivary
components of type I diabetic children (DM1) under six years of age,
to assess oral health related to diabetes control, as well as metabolite
profiling using NMR. Partial least squared discriminant analysis (PLS-DA)
was used to compare healthy (HG) and uncontrolled DM1 subjects that
demonstrated a separation between the groups with classificatory performance
of ACC = 0.80, R<sup>2</sup> = 0.92, Q<sup>2</sup> = 0.02 and for
DM1 children with glycemia >200 mg/dL of ACC = 0.74, R<sup>2</sup> = 0.91, Q<sup>2</sup> = 0.06. The metabolites that mostly contributed
to the distinction between the groups in the loading factor were acetate,
n-acetyl-sugar, lactate, and sugar. The univariate analysis showed
a decreased salivary concentration of succinic acid and increased
levels of lactate, acetate, and sucrose in uncontrolled and DM1 children
with glycemia >200 mg/dL. The present study demonstrates that the
salivary profile of DM1 differs from that of HG children. It appears
that diabetes status control has an important effect on the salivary
composition