Red blood cell distribution width/platelet ratio on admission as a predictor for in-hospital mortality in patients with acute myocardial infarction: a retrospective analysis from MIMIC-IV Database

Abstract Background Red blood cell distribution width (RDW) to platelet ratio (RPR) is a novel inflammatory indicator. It integrates the risk prediction of RDW and platelet, which is associated with adverse outcomes. However, the predictive power of RPR in mortality for patients with acute myocardial infarction (AMI) remains uncertain. Thus, we aimed to explore the association between RPR and 180-day in-hospital mortality in patients with AMI. Methods Data on patients with AMI were extracted from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Patients were divided into two groups according to the optimal RPR cut-off value. The survival curve between high and low RPR groups was plotted via the Kaplan-Meier (KM) method. Univariate and multivariate Cox regression analyses were performed to determine the association between RPR on admission and 180-day in-hospital mortality. Results A total of 1266 patients were enrolled, of which 83 (6.8%) died within 180 days during the hospitalization. Compared with the survivor group, the non-survivor group had higher RPR on admission (0.11 ± 0.07 vs. 0.08 ± 0.06, P < 0.001). The KM curve indicated that the survival probability of low RPR group was higher than that of high RPR group. Multivariate Cox regression analysis demonstrated that higher RPR on admission was an independent and effective predictor of 180-day mortality in patients with AMI (hazard ratio [HR]: 2.677, 95% confidence interval [CI]: 1.159–6.188, P = 0.021). Conclusion Higher RPR was associated with higher in-hospital 180-day mortality in patients with AMI

Effects of Outlet Shrinkage on Hydraulics in Hyper-Concentrated Sediment-Laden Flow

Finding an appropriate shape for the releasing building is thoroughly relevant given the energy dissipation and safety requirements of a high dam in a sediment-laden river. Thirty-six physical experiments on trajectory energy dissipation were conducted, researching the influence of three overflow shapes (contraction ratios of 0.5, 0.4, and 0.3) with four sediment concentrations (0, 50, 150, and 250 kg/m3) on the discharge, flow regime, and hydrodynamic pressure of a plunge pool slab. The experimental results demonstrated that the flow coefficient gradually decreased as the contraction ratio decreased in a relatively high weir head, regardless of the sediment concentration. The water nappe narrowed and the length of the longitudinal trajectory increased as the outlet shrinkage and sediment concentration decreased. With the increase in sediment concentration, the nappe regime approached stability, and the flow in the plunge pool tended toward small rolling, causing the impact pressure and fluctuating pressure to increase. Changes in overflow shape had little effect on the position of pressure peak, but the value became lower as the ratio diminished. The influence on the hydrodynamic pressure by outlet shrinkage became attenuated while the sediment concentration increased. The fluctuating energy and vortex scale were enhanced due to the increased viscosity with increasing sediment concentrations

Effect of Sediment Concentration on Hydraulic Characteristics of Energy Dissipation in a Falling Turbulent Jet

The effect of sediment on the hydraulics of jet energy dissipation is an urgent issue for high dams built on sediment-laden rivers. Accordingly, flume experiments were conducted using a ski-jump type energy dissipator in flows of four sediment concentrations (0 kg/m3, 50 kg/m3, 150 kg/m3, and 250 kg/m3) to determine the effects on discharge, flow regime, and hydrodynamic pressure in a plunge pool. The results demonstrate that the effect of sediment on discharge is constant, regardless of sediment concentration, when compared to fresh water. The width of the nappe decreased with increasing concentrations of sediment. The length of the jet trajectory increased with upstream water head. The time-averaged pressure and fluctuation pressure both exhibited peaks, describing the impact of the jet on the bottom of the plunge pool. The maximum time-averaged pressure and maximum fluctuating pressure both noticeably increased with upstream water head and slightly increased with sediment concentration for a given flow condition. The results also demonstrated that the dominant frequency of fluctuation trends to lower values, and that both the fluctuating energy and vortex scale increase with increasing sediment concentrations due to increased viscosity. These findings can be used to improve energy dissipation in dams on sediment-laden rivers

Trends in Smoking and Smoking Cessation During Pregnancy from 1985 to 2014, Racial and Ethnic Disparity Observed from Multiple National Surveys

Objective: Current report assessed the trends in smoking prevalence and the percentage of smoking cessation during pregnancy among women from three major races/ethnicities. Methods: Data were collected between 1999 and 2014 from the continuous National Health and Nutrition Examination Survey (NHANES). Smoking habits of women while pregnant with the child sampled by NHANES were assessed retrospectively. A total of 28,090 women who gave live birth between 1985 and 2014 were included. The prevalence ratios (PRs) of smoking and quitting smoking during pregnancy were calculated. The adjusted annual prevalence ratio (aaPR: the ratio associated with a 1-year increase in time) was estimated using logistic regression with the year of birth as a predictor. Results: With child’s race/ethnicity, gender, and mother’s age controlled, the aaPR of smoking was 0.95 (95% confidence interval 0.92–0.97) for Hispanics, 0.96 (0.94–0.98) for whites, and 0.98 (0.94–1.00) for blacks. The aaPR of quitting smoking was 1.09 (1.02–1.16) for Hispanics, 1.01 (0.97–1.06) for whites, and 1.03 (0.95–1.12) for blacks. Compared with the counterparts aged 35 years or older, pregnant women younger than 20 years were more likely to smoke among whites [PR 1.56 (1.07–2.29)] but less likely among blacks [PR 0.37 (0.26–0.52)]. Conclusions for Practice: Smoking prevalence has been declining continuously for all but at different rates among three major races/ethnicities. The risk profiles of smoking during pregnancy were race/ethnicity specific. Culturally appropriate programs should be developed to further reduce the maternal smoking during pregnancy

In Vitro Gene Expression Responses of Bovine Rumen Epithelial Cells to Different pH Stresses

Ruminal acidosis often occurs in production, which greatly affects animal health and production efficiency. Subacute rumen acidosis (SARA) occurs when rumen pH drops rapidly to 5.5–5.8, and acute rumen acidosis (ARA) occurs when rumen pH drops below 5.0, but the molecular regulation mechanism of the rumen epithelium after the rapid decrease in pH is still unclear. Bovine rumen epithelial cells (BRECs) were cultured at pH = 7.4 (control), 5.5 (SARA), and 4.5 (ARA). Transcriptome and metabolomic methods were used to obtain the molecular-based response of BRECs to different pH treatments; pH = 4.5 can significantly induce apoptosis of BRECs. The RNA-seq experiments revealed 1381 differently expressed genes (DEGs) in the control vs. SARA groups (p p p < 0.05) in control vs. SARA and 51 in control vs. ARA. Bioinformatics analysis using the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database revealed that drug metabolism-cytochrome P450 metabolic and alpha-linolenic acid metabolism changes occurred. These transcriptional and metabolic changes are related to the adaptation of BRECs to low-pH stresses. In conclusion, the combined data analyses presented a worthy strategy to characterize the cellular, transcriptomic, and metabonomic adaptation of BRECs to pH in vitro. We demonstrated transcriptional expression changes in BRECs under pH stress and activation of the molecular mechanisms controlling inflammation

Interactions of metal-based nanoparticles (MBNPs) and metal-oxide nanoparticles (MONPs) with crop plants: a critical review of research progress and prospects

Over the past decade, the production and applications of metal-based and metal-oxide nanoparticles (MBNPs and MONPs, respectively) have increased significantly due to their enhanced physicochemical properties and biological activities when compared with their bulk parent materials. Once MBNPs and MONPs enter agricultural soil via direct or indirect pathways, they can interact with crop plants and thus pose a threat to both animal and human health through food chain pathways. Although many review articles on engineered nanoparticles have been published, few have focused on the interactions of MBNPs and MONPs with crop plants and their current applications. Therefore, we reviewed the sources and behaviors of MBNPs and MONPs in agricultural soil, physiological and biochemical effects of MBNPs and MONPs on plants, uptake, translocation of MBNPs and MONPs in crop plants, factors affecting the interaction between MBNPs and MONPs and plants, and the applications of MBNPs and MONPs. Lastly, we propose where the future research priorities should be focused to provide a better understanding of MBNPs and MONPs. This review will help to promote scientific research regarding MBNPs and MONPs and to understand the risks and benefits of their association with plants and will contribute to the advancement of nanotechnology.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author

Effect of Peanut Shell and Rice Husk Bedding for Dairy Cows: An Analysis of Material Properties and Colostrum Microbiota

The aim of this study was to evaluate peanut shells and rice husks as bedding for dairy cows. We analyzed material properties including dry matter, water holding capacity, pH level and bacterial counts. Bedding treatments were compared with a one-way ANOVA using twelve cows split into three groups. Colostrum microbiota was analyzed by sequencing of the V3&ndash;V4 region of the 16S rRNA gene. Dry matter content was higher in rice husks compared with peanut shells. No treatment effects were found for water holding capacity and pH level. Streptococcus agalactia counts in peanut shell bedding were lower than in rice husk bedding, and Pseudomonas aeruginosa counts were not different between beddings. A significant enrichment for Enhydrobacter and Pantoea were detected in the colostrum of cows that used peanut shells compared with other beddings. Colostrum of cows housed on a peanut&ndash;rice combination had a greater relative abundance of Pseudomonas and Corynebacterium than those housed on peanut shells or rice husks. Higher numbers of Bacteroides, Akkermansia, Alistipes, Ruminococcaceae_UCG-014, Coriobacteriaceae_UCG-002 and Intestinimona were found in the colostrum of cows housed on rice husk bedding over other bedding types. These results suggest that bedding types were associated with the growth and diversity of colostrum bacterial loads. In addition, dry matter in peanut shells was lower than found in rice husks, but there was also a lower risk of mastitis for peanut shell bedding than other beddings