Effect of storage time on the silage quality and microbial community of mixed maize and faba bean in the Qinghai-Tibet Plateau

Tibetan Plateau is facing serious shortage of forage in winter and spring season due to its special geographical location. Utilization of forages is useful to alleviate the forage shortage in winter and spring season. Consequently, the current study was aimed to evaluate the influence of storage time on the silage quality and microbial community of the maize (Zea mays L.) and faba bean (Vicia faba L.) mixed silage at Qinghai-Tibet Plateau. Maize and faba bean were ensiled with a fresh weight ratio of 7:3, followed by 30, 60, 90, and 120 days of ensiling. The results showed the pH value of mixed silage was below 4.2 at all fermentation days. The LA (lactic acid) content slightly fluctuated with the extension of fermentation time, with 33.76 g/kg DM at 90 days of ensiling. The AA (acetic acid) and NH3-N/TN (ammonium nitrogen/total nitrogen) contents increased with the extension of fermentation time and no significantly different between 90 and 120 days. The CP (crude protein) and WSC (water soluble carbohydrate) contents of mixed silage decreased significantly (P < 0.05) with ensiling time, but the WSC content remained stable at 90 days. The Proteobacteria was the predominant phyla in fresh maize and faba bean, and Pseudomonas and Sphingomonas were the predominant genera. After ensiling, Lactobacillus was the prevalent genus at all ensiling days. The relative abundance of Lactococcus increased rapidly at 90 days of ensiling until 120 days of fermentation. Overall, the storage time significant influenced the silage fermentation quality, nutrient content, and microbial environment, and it remained stable for 90 days of ensiling at Qinghai-Tibet Plateau. Therefore, the recommended storage time of forage is 90 days in Qinghai-Tibet Plateau and other cool areas

Integrated Network and Experimental Pharmacology for Deciphering the Medicinal Substances and Multiple Mechanisms of Duhuo Jisheng Decoction in Osteoarthritis Therapy

Osteoarthritis (OA) is currently the most common joint disorder worldwide. In last decades, herbal remedies have achieved a significant advancement in the treatment of OA. Duhuo Jisheng Decoction (DHJS), an herbal formula consisting of 15 medicinal herbs, has a long-time practice in OA therapy in China. However, its therapeutic mechanisms have not been comprehensively elucidated. In the present work, integrated network and experimental pharmacology were performed for investigating the therapeutic substances and mechanisms of DHJS. Based on network analysis, the contribution of each herb to OA therapy was evaluated. Furthermore, a series of potential targets and signaling pathways were enriched, which could be involved in the therapeutic effects and mechanisms of DHJS. Further experimental results indicated that DHJS attenuated TNFα, IL-6, MMP-1, MMP-9, MMP-13, and ADAMTs-5 expression, inhibited NF-κB and p38 MAPK signaling pathway, activated AMPK-SIRT1 signaling pathway, and suppressed chondrocyte apoptosis, which synergistically contributed to OA therapy. Our work demonstrated that DHJS could be very promising for OA therapy through synergistically acting on multitargets and multipathways

Battery Modeling Based On The Coupling Of Electrical Circuit And Computational Fluid Dynamics

A new battery model by coupling electrical circuit and computational fluid dynamics (CFD) is proposed. It provides the insight of electrical performance as well as the temperature distribution of a battery pack. The model is potentially suitable for hybrid electric vehicle (HEV)/ electric vehicle (EV) battery modeling because of the high power and high temperature nature of these applications. © 2011 IEEE

Design for The Indoor Visible Light Communication Application System Based on LED Visible Light

This paper designs an indoor visible light communication application system based on LED. The system can modulate the original signal one or more times, move to a specific frequency band, transmit on the power line, in the LED terminal use this module to decode, restore the Ethernet signals. This design is applicable to the simplicity of the LED visible light communication applications, which provide the premise and guarantee for the construction of smart home network

Design for The Indoor Visible Light Communication Application System Based on LED Visible Light

This paper designs an indoor visible light communication application system based on LED. The system can modulate the original signal one or more times, move to a specific frequency band, transmit on the power line, in the LED terminal use this module to decode, restore the Ethernet signals. This design is applicable to the simplicity of the LED visible light communication applications, which provide the premise and guarantee for the construction of smart home network

Strain‐Enhanced Metallic Intermixing in Shape‐Controlled Multilayered Core–Shell Nanostructures: Toward Shaped Intermetallics

Controlling the surface composition of shaped bimetallic nanoparticles could offer precise tunability of geometric and electronic surface structure for new nanocatalysts. To achieve this goal, a platform for studying the intermixing process in a shaped nanoparticle was designed, using multilayered Pd‐Ni‐Pt core–shell nanocubes as precursors. Under mild conditions, the intermixing between Ni and Pt could be tuned by changing layer thickness and number, triggering intermixing while preserving nanoparticle shape. Intermixing of the two metals is monitored using transmission electron microscopy. The surface structure evolution is characterized using electrochemical methanol oxidation. DFT calculations suggest that the low‐temperature mixing is enhanced by shorter diffusion lengths and strain introduced by the layered structure. The platform and insights presented are an advance toward the realization of shape‐controlled multimetallic nanoparticles tailored to each potential application.This is the peer-reviewed version of the following article: Williams, Benjamin P., Allison P. Young, Ilektra Andoni, Yong Han, Wei‐Shang Lo, Matthew Golden, Jane Yang, Lian‐Ming Lyu, Chun-Hong Kuo, James W. Evans, Wenyu Huang, and Chia-Kuang Tsung. "Strain‐Enhanced Metallic Intermixing in Shape‐Controlled Multilayered Core–Shell Nanostructures: Toward Shaped Intermetallics." Angewandte Chemie International Edition 59, no. 26 (2020): 10574-10580, which has been published in final form at DOI: 10.1002/anie.202001067. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Posted with permission.</p

Strain‐Enhanced Metallic Intermixing in Shape‐Controlled Multilayered Core–Shell Nanostructures: Toward Shaped Intermetallics

Controlling the surface composition of shaped bimetallic nanoparticles could offer precise tunability of geometric and electronic surface structure for new nanocatalysts. To achieve this goal, a platform for studying the intermixing process in a shaped nanoparticle was designed, using multilayered Pd‐Ni‐Pt core–shell nanocubes as precursors. Under mild conditions, the intermixing between Ni and Pt could be tuned by changing layer thickness and number, triggering intermixing while preserving nanoparticle shape. Intermixing of the two metals is monitored using transmission electron microscopy. The surface structure evolution is characterized using electrochemical methanol oxidation. DFT calculations suggest that the low‐temperature mixing is enhanced by shorter diffusion lengths and strain introduced by the layered structure. The platform and insights presented are an advance toward the realization of shape‐controlled multimetallic nanoparticles tailored to each potential application

Synthesis of Various Branched Ultra-High-Molecular-Weight Polyethylenes Using Sterically Hindered Acenaphthene-Based α‑Diimine Ni(II) Catalysts

A series of highly sterically hindered acenaphthene-based α-diimine nickel complexes with the remote R group in 4-position of diarylmethyl moiety have been synthesized and characterized. Activated with Et₂AlCl, ethylene polymerization by these nickel complexes is investigated in detail, involving the remote substituent effect and influence of polymerization temperature on catalyst activity, thermal stability, polymer molecular weight, and branching density. These thermostable nickel catalysts are very active (up to 5.1 × 10⁶ g·mol^–1·h^–1) for ethylene polymerization and capable of producing various moderate to highly branched (26–71/1000 C) ultra-high-molecular-weight polyethylenes (UHMWPEs, <i>M</i>_w up to 4.5 × 10⁶ g·mol^–1). These polymeric materials with such unique structure show properties characteristic of thermoplastic elastomers, i.e., good elastomeric recovery and high strain at break

TRIB3 Mediates Fibroblast Activation and Fibrosis though Interaction with ATF4 in IPF

Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by fibroblast activation, excessive deposition of extracellular matrix, and progressive scarring; the pathogenesis remains elusive. The present study explored the role of Tribbles pseudokinase 3 (TRIB3), a well-known stress and metabolic sensor, in IPF. TRIB3 is down-regulated in the lungs of IPF patients in comparison to control subjects. Deficiency of TRIB3 markedly inhibited A549 epithelial cells’ proliferation and migration, significantly reducing wound healing. Conversely, overexpression of TRIB3 promoted A549 cell proliferation and transmigration while it inhibited its apoptosis. Meanwhile, overexpressed TRIB3 inhibited fibroblast activation and decreased ECM synthesis and deposition in MRC5 cells. TRIB3 attenuated pulmonary fibrosis by negative regulation of ATF4, while TRIB3 expression markedly inhibited ATF4 promoter-driven transcription activity and down-regulated ATF4 expression. A co-culture system showed that TRIB3 is important to maintain the normal epithelial–mesenchymal crosstalk and regulate fibroblast activation. Taken together, our data suggested that an axis of TRIB3–ATF4 is a key mediator in IPF which might be a potential target for fibroproliferative lung disease treatment