4 research outputs found
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
- Author
- AB Al-Mehdi
- AD Borowsky
- AJ Minn
- AM Havens
- B Brandt
- B Qian
- Bin-Zhi Qian
- BS Nielsen
- DR Getts
- DR Rhodes
- Elizabeth A. Kaiser
- F Geissmann
- F Geissmann
- F Geissmann
- FK Swirski
- H Saji
- HP Gerber
- Hui Zhang
- Jeffrey W. Pollard
- JH Im
- Jinghang Zhang
- Jiufeng Li
- JM Carton
- Liam R. Campion
- Linda A. Snyder
- MD Abramoff
- P Stern
- P Tsui
- RT Palframan
- T Ueno
- T Valkovic
- Takanori Kitamura
- Y Huang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2011
- Field of study
Macrophages abundantly found in the tumor microenvironment enhance malignancy(1). At metastatic sites a distinct population of metastasis associated macrophages (MAMs) promote tumor cell extravasation, seeding and persistent growth(2). Our study has defined the origin of these macrophages by showing Gr1+ inflammatory monocytes (IMs) are preferentially recruited to pulmonary metastases but not primary mammary tumors, a process also found for human IMs in pulmonary metastases of human breast cancer cells. The recruitment of these CCR2 (receptor for chemokine CCL2) expressing IMs and subsequently MAMs and their interaction with metastasizing tumor cells is dependent on tumor and stromal synthesized CCL2 (FigS1). Inhibition of CCL2/CCR2 signaling using anti-CCL2 antibodies blocks IM recruitment and inhibits metastasis in vivo and prolongs the survival of tumor-bearing mice. Depletion of tumor cell-derived CCL2 also inhibits metastatic seeding. IMs promote tumor cell extravasation in a process that requires monocyte-derived VEGF. CCL2 expression and macrophage infiltration are correlated with poor prognosis and metastatic disease in human breast cancer (Fig S2)(3-6). Our data provides the mechanistic link between these two clinical associations and indicates new therapeutic targets for treating metastatic breast disease
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
- Awan Sidra
- Ayee Robert
- Azaiz Amine
- Azzaui Harun
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Bailey Lucy
- Baillie Kenneth
- Bain William
- Baker Alice
- Baker Evelyn
- Baker Stuart
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Balls-Burgess Sam
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barber Russell
- Barbier François
- Barge Deborah
- Bariola Ryan
- Barker Gareth
- Barker Stephanie
- Barnes Nicky
- Baron Rebecca M.
- Barreau Amelie
- Barreau Amélie
- Bart Robert
- Bartholomew Jazz
- Bartley Shauna
- Barton David
- Barton Frances
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bassford Christopher
- Bastos Joana Margarida Pereira Sousa
- Bates Michelle
- Bates Samantha
- Batista Teresa Margarida Oliveira
- Bauchmuller Kris
- Bayne Madeleine
- Bean Sarah
- Beane Abi
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- Beard Gregory
- Beasley Richard
- Beaudoin Rosalie
- Beavis Sarah
- Beddows Seonaid
- Bedford Caroline
- Beer Deborah
- Beer Sally
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- Begum Salma
- Bell Gillian
- Bellemare David
- Belletti Allesandro
- Bendjemar Lynda
- Benettaib Fatna
- Bensen Nicole
- Bentley Andrew
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- Beqai Besa
- Berdaguer Fernando
- Beresford Stephanie
- Bergin Colin
- Berry Lindsay R.
- Berry Scott
- Berryman Emily
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- Chen Lixian
- Chen Yan
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- De Bus Liesbet
- de Courcy-Golder Kim
- de Groot Klaas
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- de la Torre Cisneros Julian
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- Godement Mathieu
- Godoy Lucas C.
- Goebeler M.E.
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- Kalla Ismail
- Kalogirou Michael
- Kamata Kazuhiro
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- Kamra Maneesha
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- Kannan Santhana
- Kannan Thogulava
- Kanwal Darakhshan
- Karachi Tim
- Karim Hina
- Karki Rakshya
- Karlikowski Michal
- Karlsson Sari
- Kasipandian Vidya
- Kassir Sandy
- Katary Amro
- Kato Hideaki
- Kavanagh Lisa
- Kayani Abdul
- Kayastha Srijana
- Kaye Callum
- Kazi Aayesha
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- Krishnamoorthy S
- Krishnamurthy Vinodh
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- Udayanga Ishara
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- Vaara Suvi
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- Vamplew Luke
- van Amerongen Roosmarijn
- van Bentum-Puijk Wilma
- van Bree Sjoerd
- van de Veerdonk Frank L.
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- Weber Lisa
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- Weismann Dirk
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- Weissman Alexandra
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- Williams Anna
- Williams Erin
- Williams Gemma
- Williams Hannah
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- Williamson James D
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- Willson Jayne
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- Wilson Craig
- Wilson Jean
- Wilson Maggie
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- Winters Lauren
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- Wittekamp Bastiaan
- Wittenberg Wendy
- Wnuk Chris
- Woelke Amy
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- Woods Lindsey
- Woodward Robert
- Woolett Melissa
- Worner Ruth
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- Wren Lynn
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- Wright Chris
- Wright Kim
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- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders
- Author
- Abbott Liam
- Adams Mark J.
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Akil Huda
- Albani Diego
- Albus Margot
- Alexander Madeline
- Alliey-Rodriguez Ney
- Als Thomas D.
- Amin Farooq
- Bacanu Silviu A.
- Bass Nicholas
- Bauer Michael
- Begemann Martin
- Belliveau Richard
- Bene Judit
- Bergen Sarah E.
- Bevilacqua Elizabeth
- Bigdeli Tim B.
- Black Donald W.
- Blokland Gabriëlla A.M.
- Bramon Elvira
- Breen Gerome
- Bruggeman Richard
- Buccola Nancy G.
- Buckner Randy L.
- Bulik-Sullivan Brendan
- Buxbaum Joseph D.
- Byerley William
- Byrne Enda M.
- Cahn Wiepke
- Cai Guiqing
- Cairns Murray J.
- Campion Dominique
- Cantor Rita M.
- Carr Vaughan J.
- Carrera Noa
- Catts Stanley V.
- Chambert Kimberly D.
- Chan Raymond C.K.
- Chen Chia Yen
- Chen Eric Y.H.
- Chen Ronald Y.L.
- Cheng Wei
- Cheung Eric F.C.
- Chong Siow Ann
- Cloninger C. Robert
- Cohen David
- Cohen Nadine
- Coleman Jonathan R.I.
- Collier David A.
- Colodro-Conde Lucía
- Cormican Paul
- Corvin Aiden
- Cotsapas Chris
- Craddock Nick
- Craig David W.
- Crowley James J.
- Curtis David
- Davidson Michael
- Davis Kenneth L.
- de Haan Lieuwe
- de Leeuw Christiaan A.
- Degenhardt Franziska
- Del Favero Jurgen
- Demontis Ditte
- Derks Eske M.
- Dikeos Dimitris
- Dinan Timothy
- Djurovic Srdjan
- Donohoe Gary
- Drapeau Elodie
- Duan Jubao
- Dudbridge Frank
- Durmishi Naser
- Ehrenreich Hannelore
- Eichhammer Peter
- Eriksson Johan
- Escott-Price Valentina
- Esko Tõnu
- Essioux Laurent
- Fanous Ayman H.
- Farh Kai How
- Farrell Martilias S.
- Forstner Andreas J.
- Frank Josef
- Franke Lude
- Freedman Robert
- Freimer Nelson B.
- Friedl Marion
- Friedman Joseph I.
- Fromer Menachem
- Gaspar Héléna A.
- Gejman Pablo V.
- Genovese Giulio
- Georgieva Lyudmila
- Giegling Ina
- Gill Michael
- Giusti-Rodríguez Paola
- Godard Stephanie
- Goldstein Jacqueline I.
- Golimbet Vera
- Gopal Srihari
- Gordon Scott D.
- Gratten Jacob
- Green Melissa J.
- Grove Jakob
- Hammer Christian
- Hamshere Marian L.
- Handa Robert
- Hansen Mark
- Hansen Thomas
- Haroutunian Vahram
- Hartmann Annette M.
- Henskens Frans A.
- Herms Stefan
- Hirschhorn Joel N.
- Hoffmann Per
- Hofman Andrea
- Hollegaard Mads V.
- Holmans Peter A.
- Hougaard David M.
- Howard David M.
- Huang Hailiang
- Ikeda Masashi
- Iwata Nakao
- Joa Inge
- Johnson Jessica S.
- Julià Antonio
- Jönsson Erik G.
- Kahn René S.
- Kalaydjieva Luba
- Karachanak-Yankova Sena
- Karjalainen Juha
- Kavanagh David
- Keller Matthew C.
- Kelly Brian
- Kennedy James L.
- Khrunin Andrey
- Kim Yunjung
- Kirov George
- Klovins Janis
- Knowles James A.
- Konte Bettina
- Kucinskas Vaidutis
- Kucinskiene Zita Ausrele
- Kuzelova-Ptackova Hana
- Kähler Anna K.
- Laurent Claudine
- Lee Chee Keong Jimmy
- Lee Jimmy
- Lee Phil
- Lee S. Hong
- Legge Sophie E.
- Lencz Todd
- Lerer Bernard
- Li Jun Z.
- Li Miaoxin
- Li Tao
- Liang Kung Yee
- Lieberman Jeffrey
- Limborska Svetlana
- Lind Penelope A.
- Loughland Carmel M.
- Lubinski Jan
- Lönnqvist Jouko
- Macek Milan
- Magnusson Patrik K.E.
- Maher Brion S.
- Maier Wolfgang
- Malhotra Anil K.
- Mallet Jacques
- Marsal Sara
- Martin Nicholas G.
- Mattheisen Manuel
- Mattingsdal Morten
- McCarley Robert W.
- McDonald Colm
- McIntosh Andrew M.
- McQuillin Andrew
- Medland Sarah E.
- Mehta Divya
- Meier Sandra
- Meijer Carin J.
- Melegh Bela
- Melle Ingrid
- Mesholam-Gately Raquelle I.
- Metspalu Andres
- Michie Patricia T.
- Milani Lili
- Milanova Vihra
- Mokrab Younes
- Molden Espen
- Morris Derek W.
- Mors Ole
- Mowry Bryan J.
- Murphy Kieran C.
- Murray Robin M.
- Myin-Germeys Inez
- Müller-Myhsok Bertram
- Neale Benjamin M.
- Nelis Mari
- Nenadic Igor
- Nertney Deborah A.
- Nestadt Gerald
- Nguyen Hoang
- Nicodemus Kristin K.
- Nikitina-Zake Liene
- Nisenbaum Laura
- Nordin Annelie
- Nyholt Dale R.
- O'Callaghan Eadbhard
- O'Dushlaine Colm
- O'Neill F. Anthony
- Oh Sang Yun
- Olincy Ann
- Olsen Line
- Ophoff Roel A.
- other and
- Palotie Aarno
- Pato Michele T.
- Periyasamy Sathish
- Pers Tune H.
- Rice John P.
- Richards Alexander L.
- Riley Brien P.
- Ripke Stephan
- Rujescu Dan
- Sanders Alan R.
- Schofield Peter R.
- Sham Pak C.
- Smith Daniel J.
- St Clair David
- Stahl Eli A.
- Steinberg Stacy
- Steixner-Kumar Agnes
- Sullivan Patrick F.
- Thompson Robert C.
- Tobet Stuart
- Tooney Paul A.
- Trubetskoy Vassily
- Trzaskowski Maciej
- Van Os Jim
- Visscher Peter M.
- Walters James T.R.
- Wang Yunpeng
- Weinberger Daniel R.
- Whitehead Pavlides Jennifer M.
- Wu Jing Qin
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Background: Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders suggest possible shared sex-dependent genetic risk. Methods: We conducted the largest to date genome-wide genotype-by-sex (G×S) interaction of risk for these disorders using 85,735 cases (33,403 SCZ, 19,924 BIP, and 32,408 MDD) and 109,946 controls from the PGC (Psychiatric Genomics Consortium) and iPSYCH. Results: Across disorders, genome-wide significant single nucleotide polymorphism–by-sex interaction was detected for a locus encompassing NKAIN2 (rs117780815, p = 3.2 × 10−8), which interacts with sodium/potassium-transporting ATPase (adenosine triphosphatase) enzymes, implicating neuronal excitability. Three additional loci showed evidence (p −6) for cross-disorder G×S interaction (rs7302529, p = 1.6 × 10−7; rs73033497, p = 8.8 × 10−7; rs7914279, p = 6.4 × 10−7), implicating various functions. Gene-based analyses identified G×S interaction across disorders (p = 8.97 × 10−7) with transcriptional inhibitor SLTM. Most significant in SCZ was a MOCOS gene locus (rs11665282, p = 1.5 × 10−7), implicating vascular endothelial cells. Secondary analysis of the PGC-SCZ dataset detected an interaction (rs13265509, p = 1.1 × 10−7) in a locus containing IDO2, a kynurenine pathway enzyme with immunoregulatory functions implicated in SCZ, BIP, and MDD. Pathway enrichment analysis detected significant G×S interaction of genes regulating vascular endothelial growth factor receptor signaling in MDD (false discovery rate-corrected p < .05). Conclusions: In the largest genome-wide G×S analysis of mood and psychotic disorders to date, there was substantial genetic overlap between the sexes. However, significant sex-dependent effects were enriched for genes related to neuronal development and immune and vascular functions across and within SCZ, BIP, and MDD at the variant, gene, and pathway levels.</p
Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders
- Author
- Abbott Liam
- Abdellaoui Abdel
- Adams Mark J.
- Adams Mark J.
- Adolfsson Annelie Nordin
- Adolfsson Rolf
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Agerbo Esben
- Air Tracy
- Air Tracy M.
- Akil Huda
- Albani Diego
- Albus Margot
- Alda Martin
- Alda Martin
- Alexander Madeline
- Alliey-Rodriguez Ney
- Als Thomas D.
- Als Thomas D.
- Amin Farooq
- Andlauer Till F. M.
- Andreassen Ole A.
- Andreassen Ole A.
- Anjorin Adebayo
- Antilla Verneri
- Arolt Volker
- Arranz Maria J.
- Awasthi Swapnil
- Bacanu Silviu A.
- Bacanu Silviu-Alin
- Badner Judith A.
- Bakker Steven
- Band Gavin
- Barchas Jack D.
- Barroso Ines
- Barroso Ines
- Bass Nicholas
- Bass Nicholas J.
- Bauer Michael
- Baune Bernhard T.
- Baune Bernhard T.
- Beekman Aartjan T. F.
- Begemann Martin
- Begemann Martin
- Bellenguez Céline
- Belliveau Richard
- Belliveau Richard A.
- Bellivier Frank
- Bender Stephan
- Bene Judit
- Bergen Sarah E.
- Bergen Sarah E.
- Berger Klaus
- Bevilacqua Elizabeth
- Biernacka Joanna M.
- Bigdeli Tim B.
- Bigdeli Tim B.
- Binder Elisabeth B.
- Black Donald W.
- Blackburn Hannah
- Blackwell Jenefer M.
- Blackwell Jenefer M.
- Blackwood Douglas H. R.
- Blokland Gabriëlla A. M.
- Blokland Gabriëlla A. M.
- Boks Marco P.
- Boocock James
- Boomsma Dorret I.
- Boomsma Dorret I.
- Bortolato Marco
- Bralten Janita
- Bramon Elvira
- Bramon Elvira
- Bramon Elvira
- Bramon Elvira
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Breen Gerome
- Brown Matthew A.
- Brown Matthew A.
- Bruggeman Richard
- Bryois Julien
- Buccola Nancy G.
- Buckner Randy L.
- Budde Monika
- Bulik Cynthia M.
- Bulik-Sullivan Brendan
- Bumpstead Suzannah J.
- Bunney William
- Burmeister Margit
- Burton Christie L.
- Buttenschøn Henriette N.
- Buxbaum Joseph D.
- Buxbaum Joseph D.
- Bybjerg-Grauholm Jonas
- Bybjerg-Grauholm Jonas
- Byerley William
- Byerley William
- Byrne Enda M.
- Byrne Enda M.
- Byrne Enda M.
- Bækvad-Hansen Marie
- Bækvad-Hansen Marie
- Bøen Erlend
- Børglum Anders D.
- Børglum Anders D.
- Børglum Anders D.
- Børglum Anders D.
- Børglum Anders D.
- Cahn Wiepke
- Cai Guiqing
- Cai Na
- Cairns Murray J.
- Cairns Murray J.
- Campion Dominique
- Cantor Rita M.
- Carey Caitlin E.
- Carr Vaughan J.
- Carrera Noa
- Casas Juan P.
- Casas Miquel
- Castelao Enrique
- Catts Stanley V.
- Cerrato Felecia
- Cervantes Pablo
- Cervantes Pablo
- Chambert Kimberly
- Chambert Kimberly D.
- Chan Raymond C. K.
- Charney Alexander W.
- Chen Chia-Yen
- Chen Danfeng
- Chen Eric Y. H.
- Chen Ronald Y. L.
- Cheng Wei
- Cheung Eric F. C.
- Chong Siow Ann
- Christensen Jane Hvarregaard
- Churchhouse Claire
- Cichon Sven
- Cichon Sven
- Cichon Sven
- Clarke Toni-Kim
- Clarke Toni-Kim
- Cloninger C. Robert
- Cohen David
- Cohen Nadine
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Coleman Jonathan R. I.
- Collier David A.
- Collier David A.
- Colodro-Conde Lucía
- Comes Ashley L.
- Cormican Paul
- Corvin Aiden
- Corvin Aiden
- Corvin Aiden
- Corvin Aiden
- Coryell William
- Cotsapas Chris
- Couvy-Duchesne Baptiste
- Craddock Nick
- Craddock Nick
- Craig David W.
- Crawford Gregory E.
- Crespo-Facorro Benedicto
- Crowley James J.
- Cruceanu Cristiana
- Curtis David
- Curtis David
- Czerski Piotr M.
- Dale Anders M.
- Daly Mark J.
- Dannlowski Udo
- Darvasi Ariel
- Davidson Michael
- Davies Gail
- Davis Kenneth L.
- Davis Lea K.
- de Geus Eco J. C.
- de Geus Eco J. C.
- de Haan Lieuwe
- de Jong Simone
- de Leeuw Christiaan A.
- Deary Ian J.
- Degenhardt Franziska
- Degenhardt Franziska
- Degenhardt Franziska
- Degenhardt Franziska
- Del Favero Jurgen
- Del-Favero Jurgen
- Deloukas Panos
- Deloukas Panos
- Demontis Ditte
- Demontis Ditte
- DePaulo J. Raymond
- DePaulo J. Raymond
- Derks Eske M.
- Dikeos Dimitris
- Dinan Timothy
- Direk Nese
- Djurovic Srdjan
- Djurovic Srdjan
- Djurovic Srdjan
- Dobbyn Amanda L.
- Dolan Conor V.
- Domenici Enrico
- Domenici Enrico
- Domschke Katharina
- Donnelly Peter
- Donnelly Peter
- Donohoe Gary
- Drapeau Elodie
- Dronov Serge
- Duan Jubao
- Dudbridge Frank
- Dumont Ashley
- Duncan Laramie E.
- Duncanson Audrey
- Dunn Erin C.
- Durmishi Naser
- Edenberg Howard J.
- Edkins Sarah
- Ehrenreich Hannelore
- Ehrenreich Hannelore
- Eichhammer Peter
- Eley Thalia C.
- Elvsåshagen Torbjørn
- Erdman Lauren
- Eriksson Johan
- Escott-Price Valentina
- Escott-Price Valentina
- Escott-Price Valentina
- Esko Tõnu
- Esko Tõnu
- Esko Tõnu
- Essioux Laurent
- Etain Bruno
- Fan Chun Chieh
- Fanous Ayman H.
- Faraone Stephen V.
- Farh Kai-How
- Farrell Martilias S.
- Finucane Hilary K.
- Fischer Sascha B.
- Flickinger Matthew
- Foo Jerome C.
- Foroud Tatiana M.
- Forstner Andreas J.
- Forstner Andreas J.
- Forstner Andreas J.
- Forty Liz
- Frank Josef
- Frank Josef
- Frank Josef
- Franke Lude
- Fraser Christine
- Freedman Robert
- Freeman Colin
- Freimer Nelson B.
- Freimer Nelson B.
- Friedl Marion
- Friedman Joseph I.
- Fromer Menachem
- Frye Mark
- Fullerton Janice M.
- Gade Katrin
- Gage Diane
- Garnham Julie
- Gaspar Héléna A.
- Gaspar Héléna A.
- Gejman Pablo V.
- Gejman Pablo V.
- Genovese Giulio
- Georgieva Lyudmila
- Geschwind Daniel
- Giambartolomei Claudia
- Giannoulatou Eleni
- Giegling Ina
- Giegling Ina
- Gill Michael
- Gill Michael
- Gillman Matthew
- Giusti-Rodríguez Paola
- Godard Stephanie
- Goes Fernando S.
- Goldstein Jacqueline I.
- Goldstein Jaqueline
- Goldstein Jill M.
- Goldstein Jill M.
- Goleva Slavina B.
- Golimbet Vera
- Gopal Srihari
- Gordon Scott D.
- Gordon Scott D.
- Gordon-Smith Katherine
- Grabe Hans J.
- Grabe Hans J.
- Gratten Jacob
- Gray Emma
- Green Elaine K.
- Green Melissa J.
- Greenwood Tiffany A.
- Grigoroiu-Serbanescu Maria
- Grove Jakob
- Grove Jakob
- Grove Jakob
- Grove Jakob
- Guan Weihua
- Guo Wei
- Gurling Hugh
- Guzman-Parra José
- Guzman-Parra José
- Gwilliam Rhian
- Hall Jeremy
- Hall Lynsey S.
- Hamilton Steven P.
- Hamilton Steven P.
- Hammer Christian
- Hammond Naomi
- Hamshere Marian L.
- Hamshere Marian L.
- Hamshere Marian L.
- Handa Robert
- Hansen Christine Søholm
- Hansen Christine Søholm
- Hansen Mark
- Hansen Thomas
- Hansen Thomas F.
- Haroutunian Vahram
- Hartmann Annette M.
- Hartmann Annette M.
- Hassan Kiadeh Farnush Farhadi
- Hauser Joanna
- Hautzinger Martin
- Hayward Caroline
- Heath Andrew C.
- Heilbronner Urs
- Hellenthal Garrett
- Henskens Frans A.
- Herms Stefan
- Herms Stefan
- Herms Stefan
- Hickie Ian B.
- Hipolito Maria
- Hirschhorn Joel N.
- Hoffmann Per
- Hoffmann Per
- Hoffmann Per
- Hofman Andrea
- Holland Dominic
- Hollegaard Mads V.
- Holmans Peter A.
- Holmans Peter A.
- Homuth Georg
- Horn Carsten
- Hottenga Jouke-Jan
- Hottenga Jouke-Jan
- Hougaard David M.
- Hougaard David M.
- Hougaard David M.
- Hougaard David M.
- Howard David M.
- Huang Hailiang
- Huckins Laura
- Huckins Laura M.
- Hultman Christina M.
- Hunt Sarah E.
- Hübel Christopher
- Ikeda Masashi
- Ising Marcus
- Iwata Nakao
- Iwata Nakao
- Iyegbe Conrad
- Jablensky Assen V.
- Jablensky Assen V.
- Jamain Stéphane
- Jamain Stéphane
- Jankowski Janusz
- Jansen Rick
- Jayakumar Alagurevathi
- Joa Inge
- Johnson Jessica S.
- Jones Ian
- Jones Lisa A.
- Jorgenson Eric
- Julià Antonio
- Jönsson Erik G.
- Jönsson Erik G.
- Kahn René S.
- Kahn René S.
- Kalaydjieva Luba
- Kalaydjieva Luba
- Kandaswamy Radhika
- Karachanak-Yankova Sena
- Karjalainen Juha
- Karlsson Robert
- Kavanagh David
- Keller Matthew C.
- Kelly Brian
- Kelly Brian
- Kelsoe John
- Kendler Kenneth S.
- Kendler Kenneth S.
- Kennedy James L.
- Kennedy James L.
- Khramtsova Ekaterina A.
- Khrunin Andrey
- Kim Yunjung
- Kirov George
- Kirov George
- Kittel-Schneider Sarah
- Kloiber Stefan
- Klovins Janis
- Knight Jo
- Knowles James A.
- Knowles James A.
- Knowles James A.
- Knowles James A.
- Kogevinas Manolis
- Kogevinas Manolis
- Kohane Isaac S.
- Koller Anna C.
- Konte Bettina
- Konte Bettina
- Kraft Julia
- Kretzschmar Warren W.
- Kucinskas Vaidutis
- Kucinskiene Zita Ausrele
- Kupka Ralph
- Kutalik Zoltán
- Kuzelova-Ptackova Hana
- Kähler Anna K.
- Landén Mikael
- Langford Cordelia
- Laurent Claudine
- Lavebratt Catharina
- Lawrence Jacob
- Lawrie Stephen
- Lawson William B.
- Leber Markus
- Leboyer Marion
- Lee Chee Keong Jimmy
- Lee Jimmy
- Lee Phil
- Lee Phil H.
- Lee Phil H.
- Lee S. Hong
- Legge Sophie E.
- Lencz Todd
- Lencz Todd
- Lerer Bernard
- Levinson Douglas F.
- Levinson Douglas F.
- Levinson Douglas F.
- Levy Shawn E.
- Lewis Cathryn M.
- Lewis Cathryn M.
- Lewis Cathryn M.
- Lewis Glyn
- Li Jun Z.
- Li Miaoxin
- Li Qingqin S.
- Li Qingqin S.
- Li Tao
- Li Yihan
- Liang Kung-Yee
- Liddle Jennifer
- Lieberman Jeffrey
- Limborska Svetlana
- Lin Kuang
- Lind Penelope A.
- Linszen Don H.
- Lissowska Jolanta
- Liu Chunyu
- Liu Jianjun
- Loughland Carmel M.
- Lubinski Jan
- Lucae Susanne
- Lucae Susanne
- Lucae Susanne
- Lönnqvist Jouko
- Maaser Anna
- Macek Milan
- MacIntyre Donald J.
- MacIntyre Donald J.
- MacKinnon Dean F.
- Madden Pamela AF.
- Magnusson Patrik K.
- Magnusson Patrik K. E.
- Magnusson Patrik K. E.
- Maher Brion S.
- Mahon Pamela B.
- Maier Robert M.
- Maier Wolfgang
- Maier Wolfgang
- Maier Wolfgang
- Malhotra Anil K.
- Malhotra Anil K.
- Mallet Jacques
- Marchini Jonathan
- Markus Hugh S.
- Marsal Sara
- Martin Joanna
- Martin Nicholas G.
- Martin Nicholas G.
- Martinsson Lina
- Mata Ignacio
- Mathew Christopher G.
- Mathew Christopher G.
- Mathews Carol A.
- Mattheisen Manuel
- Mattheisen Manuel
- Mattheisen Manuel
- Mattheisen Manuel
- Mattingsdal Morten
- Mayoral Fermin
- Mbarek Hamdi
- McCann Owen T.
- McCarley Robert W.
- McCarroll Steve
- McCarroll Steven A.
- McCarthy Mark I.
- McDonald Colm
- McElroy Susan L.
- McGrath Patrick
- McGuffin Peter
- McGuffin Peter
- McInnis Melvin G.
- McIntosh Andrew M.
- McIntosh Andrew M.
- McIntosh Andrew M.
- McIntosh Andrew M.
- McKay James D.
- McQuillin Andrew
- McQuillin Andrew
- McQuillin Andrew
- Medeiros Helena
- Medland Sarah E.
- Medland Sarah E.
- Mehta Divya
- Mehta Divya
- Meier Sandra
- Meijer Carin J.
- Melegh Bela
- Melle Ingrid
- Melle Ingrid
- Meng Fan
- Mesholam-Gately Raquelle I.
- Metspalu Andres
- Metspalu Andres
- Michie Patricia T.
- Middeldorp Christel M.
- Mihailov Evelin
- Milaneschi Yuri
- Milaneschi Yuri
- Milani Lili
- Milani Lili
- Milani Lili
- Milani Lili
- Milanova Vihra
- Mill Jonathan
- Mirza Saira Saeed
- Mitchell Philip B.
- Mokrab Younes
- Molden Espen
- Mondimore Francis M.
- Montgomery Grant W.
- Montgomery Grant W.
- Moran Jennifer L.
- Morris Derek W.
- Morris Derek W.
- Mors Ole
- Mors Ole
- Mors Ole
- Mors Ole
- Mortensen Preben B.
- Mortensen Preben B.
- Mortensen Preben Bo
- Mortensen Preben Bo
- Mostafavi Sara
- Mowry Bryan J.
- Mowry Bryan J.
- Mullins Niamh
- Mullins Niamh
- Mullins Niamh
- Murphy Kieran C.
- Murray Robin M.
- Murray Robin M.
- Murray Robin M.
- Myin-Germeys Inez
- Mühleisen Thomas W.
- Müller-Myhsok Bertram
- Müller-Myhsok Bertram
- Müller-Myhsok Bertram
- Nauck Matthias
- Neale Benjamin M.
- Neale Benjamin M.
- Nelis Mari
- Nenadic Igor
- Nertney Deborah A.
- Nestadt Gerald
- Ng Bernard
- Nguyen Hoang
- Nicodemus Kristin K.
- Nievergelt Caroline M.
- Nikitina-Zake Liene
- Nisenbaum Laura
- Nivard Michel G.
- Nordentoft Merete
- Nordentoft Merete
- Nordentoft Merete
- Nordin Annelie
- Nwulia Evaristus A.
- Nyholt Dale R.
- Nöthen Markus
- Nöthen Markus M.
- Nöthen Markus M.
- Nöthen Markus M.
- O'Donovan Claire
- O'Donovan Michael C.
- O'Reilly Paul F.
- Oh Sang-Yun
- Olde Loohuis Loes M.
- Olincy Ann
- Olsen Line
- Ophoff Roel A.
- Ophoff Roel A.
- Ophoff Roel A.
- Ori Anil P. S.
- Oruc Lilijana
- Oskarsson Hogni
- Owen Michael
- Owen Michael J.
- Owen Michael J.
- O’Callaghan Eadbhard
- O’Donovan Claire
- O’Donovan Michael C.
- O’Dushlaine Colm
- O’Neill F. Anthony
- Paciga Sara A.
- Painter Jodie N.
- Palmer Colin N. A.
- Palotie Aarno
- Palotie Aarno
- Pantelis Christos
- Papadimitriou George N.
- Papiol Sergi
- Parkhomenko Elena
- Pato Carlos N.
- Pato Michele T.
- Pato Michele T.
- Paunio Tiina
- Pearson Richard
- Pedersen Carsten Bøcker
- Pedersen Carsten Bøcker
- Pedersen Marianne Giørtz
- Pedersen Marianne Giørtz
- Pedersen Nancy L.
- Pejovic-Milovancevic Milica
- Penninx Brenda W. J. H.
- Penninx Brenda W. J. H.
- Periyasamy Sathish
- Periyasamy Sathish
- Perkins Diana O.
- Perlis Roy H.
- Perlis Roy H.
- Perlis Roy H.
- Perry Amy
- Pers Tune H.
- Pers Tune H.
- Peterson Roseann E.
- Peterson Roseann E.
- Petryshen Tracey L.
- Petryshen Tracey L.
- Petryshen Tracey L.
- Peyrot Wouter J.
- Pfennig Andrea
- Pietiläinen Olli
- Pimm Jonathan
- Pirinen Matti
- Pistis Giorgio
- Plath Niels
- Plomin Robert
- Pocklington Andrew J.
- Porteous David J.
- Posthuma Danielle
- Posthuma Danielle
- Potash James B.
- Potash James B.
- Potash James B.
- Potter Simon C.
- Powell John
- Powell John
- Preisig Martin
- Preisig Martin
- Price Alkes
- Pulver Ann E.
- Purcell Shaun M.
- Purcell Shaun M.
- Quested Digby
- Quiroz Jorge A.
- Qvist Per
- Rasmussen Henrik B.
- Rautanen Anna
- Ravindrarajah Radhi
- Regeer Eline J.
- Reichenberg Abraham
- Reif Andreas
- Reif Andreas
- Reimers Mark A.
- Reinbold Céline S.
- Rice John P.
- Rice John P.
- Richards Alexander L.
- Richards Alexander L.
- Ricketts Michelle
- Rietschel Marcella
- Rietschel Marcella
- Rietschel Marcella
- Riley Brien P.
- Riley Brien P.
- Riley Brien P.
- Ripke Stephan
- Ripke Stephan
- Ripke Stephan
- Rivas Fabio
- Rivera Margarita
- Rivera Margarita
- Robinson Elise
- Roffman Joshua L.
- Roussos Panos
- Roussos Panos
- Ruderfer Douglas M.
- Ruderfer Douglas M.
- Rujescu Dan
- Rujescu Dan
- Rujescu Dan
- Ryu Euijung
- Salomaa Veikko
- Sanders Alan R.
- Sanders Alan R.
- Sawcer Stephen J.
- Schaefer Catherine
- Schall Ulrich
- Schatzberg Alan F.
- Schaupp Sabrina
- Scheftner William A.
- Schoevers Robert
- Schofield Peter R.
- Schork Nicholas J.
- Schubert Christian R.
- Schulte Eva C.
- Schulze Thomas G.
- Schulze Thomas G.
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- Schwab Sibylle G.
- Scolnick Edward M.
- Scott Laura J.
- Scott Rodney J.
- Seidman Larry J.
- Sham Pak C.
- Sham Pak C.
- Shehktman Tatyana
- Shen Ling
- Shi Jianxin
- Shi Jianxin
- Shi Jianxin
- Shilling Paul D.
- Shyn Stanley I.
- Sigurdsson Engilbert
- Sigurdsson Engilbert
- Sigurdsson Engilbert
- Silagadze Teimuraz
- Silverman Jeremy M.
- Sim Kang
- Sinnamon Grant C. B.
- Sirignano Lea
- Skajaa Kristjar
- Sklar Pamela
- Slaney Claire
- Slominsky Petr
- Smeland Olav B.
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- Smit Johannes H.
- Smith Daniel J.
- Smoller Jordan W.
- Smoller Jordan W.
- Smoller Jordan W.
- Smoller Jordan W.
- So Hon-Cheong
- Sobell Janet L.
- Spencer Chris C. A.
- Spencer Chris C. A.
- Spencer Chris C. A.
- Spijker Anne T.
- St Clair David
- St Clair David
- St Clair David
- Stahl Eli
- Stahl Eli A.
- Stahl Eli A.
- Stahl Eli A.
- Stefansson Hreinn
- Stefansson Hreinn
- Stefansson Kari
- Stefansson Kari
- Steffens Michael
- Steinberg Stacy
- Steinberg Stacy
- Steinberg Stacy
- Steixner-Kumar Agnes
- Stogmann Elisabeth
- Strange Amy
- Stranger Barbara E.
- Straub Richard E.
- Strauss John S.
- Streit Fabian
- Streit Fabian
- Streit Fabian
- Strengman Eric
- Strohmaier Jana
- Strohmaier Jana
- Strohmaier Jana
- Stroup T. Scott
- Su Zhan
- Subramaniam Mythily
- Sullivan Patrick F.
- Sullivan Patrick F.
- Sullivan Patrick F.
- Suvisaari Jaana
- Svrakic Dragan M.
- Szatkiewicz Jin P.
- Szelinger Szabolcs
- Sánchez-Mora Cristina
- Söderman Erik
- Tansey Katherine E.
- Tashakkori-Ghanbaria Avazeh
- Teismann Henning
- Teumer Alexander
- Teumer Alexander
- Thirumalai Srinivas
- Thompson Robert C.
- Thompson Wesley
- Thomson Pippa A.
- Thorgeirsson Thorgeir E.
- Thorgeirsson Thorgeir E.
- Tiemeier Henning
- Tiemeier Henning
- Tobet Stuart
- Toncheva Draga
- Tooney Paul A.
- Tooney Paul A.
- Tosato Sarah
- Traglia Michela
- Traylor Matthew
- Trembath Richard C.
- Treutlein Jens
- Treutlein Jens
- Trubetskoy Vassily
- Trubetskoy Vassily
- Trzaskowski Maciej
- Trzaskowski Maciej
- Uher Rudolf
- Uher Rudolf
- Uitterlinden André G.
- Umbricht Daniel
- Vaaler Arne E.
- Van der Auwera Sandra
- Van der Auwera Sandra
- van Hemert Albert M.
- Van Os Jim
- Van Os Jim
- Vedder Helmut
- Veijola Juha
- Viktorin Alexander
- Viktorin Alexander
- Vincent John B.
- Visscher Peter M.
- Visscher Peter M.
- Viswanathan Ananth C.
- Vukcevic Damjan
- Völker Uwe
- Völzke Henry
- Waddington John
- Waller Matthew
- Walsh Dermot
- Walshe Muriel
- Walters James T. R.
- Walters Raymond K.
- Wang Dai
- Wang Qiang
- Wang Weiqing
- Wang Yunpeng
- Wang Yunpeng
- Watson Stanley J.
- Webb Bradley T.
- Webb Bradley T.
- Weickert Cynthia Shannon
- Weickert Thomas W.
- Weinberger Daniel R.
- Weinberger Daniel R.
- Weinsheimer Shantel Marie
- Weisbrod Matthias
- Weiser Mark
- Weiss Lauren A.
- Weissman Myrna M.
- Weissman Myrna M.
- Wellmann Jürgen
- Wendland Jens R.
- Werge Thomas
- Werge Thomas
- Werge Thomas
- Werge Thomas
- Werge Thomas
- Weston Paul
- Whitehead Pavlides Jennifer M.
- Whittaker Pamela
- Widaa Sara
- Wiersma Durk
- Wildenauer Dieter B.
- Willemsen Gonneke
- Willemsen Gonneke
- Williams Nigel M.
- Williams Stephanie
- Winham Stacey J.
- Witt Stephanie H.
- Witt Stephanie H.
- Witt Stephanie H.
- Wolen Aaron R.
- Wong Emily H. M.
- Wood Nicholas W.
- Wormley Brandon K.
- Wray Naomi R.
- Wray Naomi R.
- Wray Naomi R.
- Wu Jing Qin
- Wu Jing Qin
- Wu Yang
- Xi Hualin S.
- Xi Hualin Simon
- Xi Simon
- Xu Wei
- Yang Jian
- Yao Yin
- Yolken Robert H.
- Young Allan H.
- Zai Clement C.
- Zandi Peter
- Zhang Futao
- Zhang Peng
- Zheng Xuebin
- Zimprich Fritz
- Zöllner Sebastian
- Ösby Urban
- Świątkowska Beata
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study