TDAE Strategy in the Benzoxazolone Series: Synthesis and Reactivity of a New Benzoxazolinonic Anion

International audienceWe describe an original pathway to produce new 5-substituted 3-methyl-6-nitro-benzoxazolones by the reaction of aromatic carbonyl and α-carbonyl ester derivatives with a benzoxazolinonic anion formed exclusively via the TDAE strategy

Original TDAE reactivity in benzoxa- and benzothiazolone series

We present herein an extension of the TDAE strategy using original heterocyclic carbaldehyde as electrophiles. We also evaluate the influence of the presence of nitro group on the reactivity. The TDAE-initiated reactions of various halomethyl and gem-dihalomethyl derivatives with nonnitrated carbaldehyde 1 or 2 formed the expected products accompagnied by original rearranged products while the presence of a nitro group just like the carbaldehyde 21 furnished only the expected products in good yields

Experimental synthesis, biological evaluation, theoretical investigations of some novel benzoxazolinone based Schiff under eco-environmental conditions as potential antioxidant agents

International audienceIn this paper, we have developed a new, non-hazardous and eco-friendly access route for the synthesis of a novel Schiff bases containing 2-oxo-3H-benzoxazole scaffold 4(a-f) by lemon juice as natural catalyzed acid under solvent-free conditions. The chemical structures of the new synthesized compounds were elucidated on the basis of the FT-IR, 1 H and 13 C-NMR spectroscopic techniques and all molecules were isolated with moderate yields after shorter reaction times. Furthermore, a preliminary study on the in vitro antioxidant activity of some synthesized compounds was investigated. The biological activity results revealed that highest DPPH radical-scavenging activity was observed for compound 4e with an IC 50 of 2.13 μg.mL −1 , more active than the standard ascorbic acid (IC 50 = 2.16 μg.mL −1). In-silico studies based on density functional theory (DFT) were realized to rationalize the biological activity with the structural and electronic properties of the 6-imino-2-oxo-3H-benzoxazoles. We using the molecular docking simulation to study the affinity and the possible binding mode of complexed ligand-protein. The synthesized molecules were tested to cross the clinical test by the ADMET prediction, these results indicated that the compounds 4(a-f) have excellent drug-likeness properties

One‐Pot Microwave‐Assisted Synthesis, in Vitro Anti‐inflammatory Evaluation and Computer‐Aided Molecular Design of Novel Sulfamide‐Containing Bisphosphonates Derivatives

International audienceAn eco-friendly and one-step microwave-assisted green synthesis of new functionalized bisphosphonates derivatives was described by a three-component reaction of aromatic sulfamide with triethyl orthoformate and diethyl phosphite. The synthesized compounds were characterized by 1 H, 13 C, 31 P NMR and IR analysis. Some of these compounds were tested for in vitro anti-inflammatory activity and showed moderate inhibition compared to diclofenac as standard drug. Furthermore, to rationalize the observed biological data, several in silico approaches have been used to explain Structure-Activity Relationship study (SAR) based on DFT calculation, molecular docking, pharmacodynamic, pharmacokinetic and toxicity profiles of sulfamide-containing bisphosphonates derivatives as anti-inflammatory drugs. The results of the in vitro and in silico activities prove that the compound 4 b have the ideal structural requirements for further development of novel anti-inflammatory agents

Experimental synthesis, biological evaluation, theoretical investigations of some novel benzoxazolinone based Schiff under eco-environmental conditions as potential antioxidant agents

International audienceIn this paper, we have developed a new, non-hazardous and eco-friendly access route for the synthesis of a novel Schiff bases containing 2-oxo-3H-benzoxazole scaffold 4(a-f) by lemon juice as natural catalyzed acid under solvent-free conditions. The chemical structures of the new synthesized compounds were elucidated on the basis of the FT-IR, 1 H and 13 C-NMR spectroscopic techniques and all molecules were isolated with moderate yields after shorter reaction times. Furthermore, a preliminary study on the in vitro antioxidant activity of some synthesized compounds was investigated. The biological activity results revealed that highest DPPH radical-scavenging activity was observed for compound 4e with an IC 50 of 2.13 μg.mL −1 , more active than the standard ascorbic acid (IC 50 = 2.16 μg.mL −1). In-silico studies based on density functional theory (DFT) were realized to rationalize the biological activity with the structural and electronic properties of the 6-imino-2-oxo-3H-benzoxazoles. We using the molecular docking simulation to study the affinity and the possible binding mode of complexed ligand-protein. The synthesized molecules were tested to cross the clinical test by the ADMET prediction, these results indicated that the compounds 4(a-f) have excellent drug-likeness properties