Remembering the Past, Shaping the Future: Memory Frictions and Nation-Making in Timor-Leste

This Discussion Paper investigates state-sponsored memorialisation and commemoration in Timor-Leste and what effect that it has on nation building effortsAusAI

Influences and echoes of Indonesia in Timor-Leste

This paper presents four case studies that highlight how Indonesia and Timor-Leste remain intricately entwined at the social, political, cultural and personal levels. Abstract Since 1999, when a United Nations (UN) transitional administration was established in the wake of the East Timorese vote for independence from Indonesia, the case of Timor-Leste has been a relative mainstay in research and policy debates on post-conflict reconstruction. Timor- Leste is often characterised by scholars as a ‘postconflict’ country and, as a consequence, compared to other countries that have recently emerged from political strife. While this focus is understandable, it has also meant that surprisingly little scholarly attention has focused on the connections, points of similarity and interrelations between Timor- Leste and its near neighbour and former occupier Indonesia. Only recently have researchers begun to explore the multiple dimensions of Timor-Leste/ Indonesian relations and unpack the relationship across a range of disciplines

Assessing the Terms of Inclusion in the State of Timor-Leste

This In Brief provides an overview of the main themes emerging from the 2015 Timor-Leste Update conference held at the Australian National University, 19–20 November 2015. Organised by the State, Society and Governance in Melanesia Program (SSGM), the conference brought together academics and policymakers from Timor-Leste, Australia and Portugal, taking as its point of departure the ‘terms of inclusion’ of citizens in the state of Timor-Leste and of Timor-Leste in its region.AusAI

Chega! Ten Years On: A Neglected National Resource : The Fate of the CAVR Final Report in Timor-Leste

It is now 10 years since the publication of Chega! (the final report of the Commission for Reception, Truth and Reconciliation, known by its Portuguese acronym, ‘CAVR’). The CAVR was tasked with documenting human rights violations committed throughout Timor-Leste’s 24-year-long armed conflict and making recommendations on how to address the negative impact of the conflict, including measures to prevent its recurrence. This report presents the key findings of a project that assesses some dimensions of Chega!’s impact in Timor-Leste.1 The project consisted of two components. The first component examined how ‘key actors’ — defined as prominent figures in the government, parliament, education sector, Catholic Church, media and civil society organisations — perceive and utilise Chega! The second component assessed different programs designed to disseminate and ‘socialise’ Chega! amongst Timorese. The methodology involved a desk review of publicly available speeches and documents, interviews with 28 key actors, interviews with students exposed to Chega!-socialisation programs and an analysis of students’ written responses to such programs.Australian Department of Foreign Affairs and Trad

Poor People’s Politics in East Timor

YesPoor people attempting to claim a share of resources in post-conflict societies seek allies internationally and nationally in attempts to empower their campaigns. In so doing, they mobilize the languages of liberalism, nationalism and local cultural tradition selectively and opportunistically to both justify stances that transgress the strictures of local culture and to cement alliances with more powerful actors. In the case of poor widows in East Timor, the languages of nationalism, ritual, and justice were intermingled in a campaign aimed at both international actors and the national state in a bid to claim a position of status in the post-conflict order

Hidden politics of power and governmentality in transitional justice and peacebuilding:The problem of ‘bringing the local back in’

This paper examines ‘the local’ in peacebuilding by examining how ‘local’ transitional justice projects can become spaces of power inequalities. The paper argues that focusing on how ‘the local’ contests or interacts with ‘the international’ in peacebuilding and post-conflict contexts obscures contestations and power relations amongst different local actors, and how inequalities and power asymmetries can be entrenched and reproduced through internationally funded local projects. The paper argues that externally funded projects aimed at emancipating ‘locals’ entrench inequalities and create local elites that become complicit in governing the conduct and participation of other less empowered ‘locals’. The paper thus proposes that specific local actors—often those in charge of externally funded peacebuilding projects—should also be conceptualised as governing agents: able to discipline and regulate other local actors’ voices and their agency, and thus (re)construct ideas about what ‘the local’ is, or is not

Rare and low-frequency coding variants alter human adult height

Height is a highly heritable, classic polygenic trait with ~700 common associated variants identified so far through genome - wide association studies . Here , we report 83 height - associated coding variants with lower minor allele frequenc ies ( range of 0.1 - 4.8% ) and effects of up to 2 16 cm /allele ( e.g. in IHH , STC2 , AR and CRISPLD2 ) , >10 times the average effect of common variants . In functional follow - up studies, rare height - increasing alleles of STC2 (+1 - 2 cm/allele) compromise d proteolytic inhibition of PAPP - A and increased cleavage of IGFBP - 4 in vitro , resulting in higher bioavailability of insulin - like growth factors . The se 83 height - associated variants overlap genes mutated in monogenic growth disorders and highlight new biological candidates ( e.g. ADAMTS3, IL11RA, NOX4 ) and pathways ( e.g . proteoglycan/ glycosaminoglycan synthesis ) involved in growth . Our results demonstrate that sufficiently large sample sizes can uncover rare and low - frequency variants of moderate to large effect associated with polygenic human phenotypes , and that these variants implicate relevant genes and pathways

Genetic mechanisms of critical illness in COVID-19.

Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice