Gene expression changes upon RSV infection in mice for the shared set of 53 genes in lung, lymph node, and blood on days 1, 2, and 5.

<p>Blood data are indicated as follows: primary, primary RSV infection response; protective, secondary RSV infection response; adverse, FI-RSV vaccine-enhanced response. Data for lung and lymph node are all responses to primary RSV infection. Values are given as ratios between infected and control.</p

Functional enrichment for lung, lymph node, and blood responses.

<p>Nodes represent tissue responses (pink), shared primary response (red), GO/UniProt functional terms (yellow) and immune cell type (light blue). Edges represent significant (p<0.01) enrichment (dark blue) or a subset relation (gray).</p

Gene expression changes upon RSV infection in mice for primary infection, secondary infection, and vaccine-enhanced signatures in blood on day 5.

<p>Values are given as ratios between infected and control.</p

Module comparison of expression responses.

<p>Figures indicate the median response per module. Background color indicates the extent of up- (red) or down-regulation.</p

Comparison between lung, lymph node, and blood responses.

<p>The Venn diagram indicates the number of genes regulated in common or specific for each of the three tissues across any of the days examined. The heatmap indicates gene expression changes relative to the median of the unchallenged group on days 1, 2, and 5.</p