Haplotype of gene Nedd4 binding protein 2 associated with sporadic nasopharyngeal carcinoma in the Southern Chinese population-0

<p><b>Copyright information:</b></p><p>Taken from "Haplotype of gene Nedd4 binding protein 2 associated with sporadic nasopharyngeal carcinoma in the Southern Chinese population"</p><p>http://www.translational-medicine.com/content/5/1/36</p><p>Journal of Translational Medicine 2007;5():36-36.</p><p>Published online 13 Jul 2007</p><p>PMCID:PMC1947948.</p><p></p>d as a control. (B) Expression of and mRNA in matched tissues. RT-PCR was performed with gene-specific primers and as a control. up-low: normal tissue; down-low: tumor tissue. (C) Expression of and mRNA nasopharyngeal tissues. Inf.: chronic nasopharynx inflammation; NDNK: Undifferentiated Carcinoma; DNK: Differentiated Carcinoma; LDS: Low differentiated squamous carcinoma; NHL: non-Hodgkin's lymphoma

Kaplan–Meier survival analysis of baseline LMR in NPC patients.

<p>A. OS curves for LMR; B. DFS curves for LMR; C. DMFS curves for LMR; D. LRRFS curves for LMR. LMR, lymphocyte-to-monocyte ratio; NPC, nasopharyngeal carcinoma; OS, overall survival; DFS, disease-free survival; DMFS, distant metastasis-free survival; LRRFS, loco-regional recurrence-free survival.</p

Multivariate analysis of independent prognostic factors for patients with nasopharyngeal carcinoma (n = 1547).

<p>Abbreviation: OS  =  Overall Survival; DFS  =  Disease-Free Survival; DMFS  =  Distant Metastasis-Free Survival; LRRFS  =  Loco-Regional Recurrence-Free Survival; CRT  =  chemoradiotherapy; RT  =  radiotherapy; LMR  =  lymphocyte-to-monocyte ratio; HR  =  Hazard Ratio, derived from COX proportional hazard model. In this analysis, T status, N status and tumor stage were divided into two groups. For T status: T1-2 and T3-4; for N status:N0-1 and N2-3; for tumor stage: I–II and III–IV.</p

Kaplan–Meier survival analysis of baseline lymphocyte count (LY) in NPC patients.

<p>A. OS curves for LY; B. DFS curves for LY; C. DMFS curves for LY; D. LRRFS curves for LY. LY, lymphocyte count; NPC, nasopharyngeal carcinoma; OS, overall survival; DFS, disease-free survival; DMFS, distant metastasis-free survival; LRRFS, loco-regional recurrence-free survival.</p

Univariate analysis of prognostic factors for patients with nasopharyngeal carcinoma.

<p>Abbreviation: OS  =  Overall Survival; DFS  =  Disease-Free Survival; DMFS  =  Distant Metastasis-Free Survival; LRRFS  =  Loco-Regional Recurrence-Free Survival; CRT  =  chemoradiotherapy; RT =  radiotherapy; LMR  =  lymphocyte-to-monocyte ratio; HR  =  Hazard Ratio, derived from COX proportional hazard model.</p

Kaplan–Meier survival analysis of baseline monocyte count (MO) in NPC patients.

<p>A. OS curves for MO; B. DFS curves for MO; C. DMFS curves for MO; D. LRRFS curves for MO. MO, monocyte count; NPC, nasopharyngeal carcinoma; OS, overall survival; DFS, disease-free survival; DMFS, distant metastasis-free survival; LRRFS, loco-regional recurrence-free survival.</p

Multivariate analyses of clinical variables, demographics and lifestyle behaviors to predict survival.

<p>Note: Each HR is adjusted simultaneously for all the other variables in the table.</p><p>Abbreviation: HR, Hazard Ratio.</p

Univariate hazard ratios from Cox proportional hazards regression models.

<p>Abbreviation: HR, Hazard Ratio; CRT, Concurrent chemoradiotherapy; RT+CT, Radiotherapy+Chemotherapy.</p

Kaplan-Meier plots of the influence of various lifestyle behaviors on survival in NPC patients.

<p>(A) Smoking status; (B) Lifetime cigarette consumption; (C) Alcohol intake; (D) Duration of alcohol intake; (E) Frequency of fruit intake; (F) Body-mass index.</p

A Comparison between the Sixth and Seventh Editions of the UICC/AJCC Staging System for Nasopharyngeal Carcinoma in a Chinese Cohort

<div><p>Background</p><p>The International Union Against Cancer/American Joint Committee on Cancer (UICC/AJCC) TNM staging system of nasopharyngeal carcinoma (NPC) is the most important system for survival prediction. The TNM 7th edition UICC/AJCC TNM staging system for NPC was adopted in January 2009, and is now internationally recommended. In comparison with the TNM 6th edition, there were several revisions in the new edition staging system. This study aims to evaluate the prognostic value of the TNM 7th edition for NPC patients in comparison with the TNM 6th edition.</p><p>Method</p><p>Clinical data of 2,629 NPC patients from the Sun Yat-sen University Cancer Center between January 2006 and December 2010 were retrospectively collected and all the patients were restaged according to the criteria of the TNM 6th edition and TNM 7th edition UICC/AJCC staging manual. Univariate and multivariate COX proportional hazards analyses were applied to evaluate the prognostic values between adjacent stage categories of the TNM 6th edition and TNM 7th edition.</p><p>Results</p><p>In comparison with the TNM 6th edition, a significant alteration of the distribution of N categories was observed when the TNM 7th edition was applied (χ² = 20.589, P<0.001), with 119 (119/670, 17.8%) patients up-staging from N0 to N1. With regard to T and overall stage, 37 (37/561, 6.6%) patients were down-staged from T2a with the TNM 6th edition to T1 with the TNM 7th edition, and finally two patients were up-staged to overall stage II (2/118, 1.7%). Moreover, the survival curves were significantly segregated (P<0.05) between T1 and T2 as well as N1 and N2 with the TNM 7th edition.</p><p>Conclusions</p><p>The TNM 7th edition led to a significant alteration in the distribution of N categories and it is superior to the TNM 6th edition in predicting the frequency of overall survival and distant metastasis-free survival.</p></div