Biphenyl-3,3′-dicarb­oxy­lic acid

The asymmetric unit of the title compound, C14H10O4, contains one half mol­ecule, the complete mol­ecule being generated by a twofold axis. The two benzene rings form a dihedral angle of 43.11 (5)°. Inter­molecular O—H⋯O hydrogen bonds link the mol­ecules into one-dimensional zigzag chains. These chains are further connected into two-dimensional supra­molecular layers by weak π–π stacking inter­actions between neighbouring benzene rings, with centroid–centroid distances of 3.7648 (8) Å

Bis(2-methyl­imidazolium) chloranilate

The asymmetric unit of the title structure, 2C4H7N2 +·C6Cl2O4 2−, consists of one 2-methyl­imidazolium cation and one-half of a chloranilate anion, the formula unit being generated by crystallographic inversion symmetry. N—H⋯O hydrogen bonds link the ions into a two-dimensional framework parallel to the (102) plane. No π–π stacking or C—H⋯π inter­actions are observed in the crystal structure

Low-cycle Fatigue and Fracture Behaviour of 9%Ni Steel Flux Cored Arc Welding joint at Cryogenic Temperature

In the present work, low-cycle fatigue (LCF) test and crack tip opening displacement (CTOD) test were performed for 9% Ni steel flux cored arc welding (FCAW) joint at room temperature (296 K) and cryogenic temperature (80 K). At cryogenic temperature, the strain amplitude had a far greater impact on fatigue life of 9%Ni steel welded joint and it decreased dramatically lead to a significant increase in fatigue life. It was found that most fracture initiation of joints located in fusion area at room temperature, while it occurred in weld seam at low temperature. The fracture toughness of weld seam was higher than that of fusion zone no matter the testing temperature. The effect of precipitated phase was the true reason. The fatigue cracks propagated in transgranular mode at room temperature, ultimately, and intergranular mode at low temperature in both LCF specimens and CTOD specimens

Further discussion on soil and water conservation effect on water resources in the Yellow River Basin -TASAE, 2004 Further discussion on the effect of soil and water conservation on water resources in the Yellow River Basin

In the last half century, because of climate change and large scale human activities, such as water resources engineering, water use of industry, agriculture, and soil and water conservation practices (SWCP), the water resource problems in the Yellow River Basin (YRB) have become more obvious. As a result of sediment erosion control, runoff has decreased in the YRB, and therefore its impact on water resources has become an issue of great concerned. Cui (2002) blamed rainfall reduction and SWCP for cutting-off of flowing to the sea. Chen Characteristics and problems of water resources in the YRB The amount and per capita volume of water resources are both very low. The lack of water resource in the YRB in the last fifty years is not only because the water resources distribution is not temporally and spatially even

Case report: Efficacy of icotinib treatment in lung adenocarcinoma with esophageal squamous cell carcinoma: a rare case of double primary malignant tumors

BackgroundLung adenocarcinoma with esophageal squamous cell carcinoma is rare and the prognosis is poor, therefore there is an urgent need to improve this situation. The objective of this study was to explore the effect of first-generation tyrosine kinase inhibitors (TKIs) in the patient of the double primary malignant tumors.Case reportWe report a case of lung adenocarcinoma with esophageal squamous cell carcinoma treated by icotininb after five-year follow-up. A 71-year-old Chinese woman complaining of swallowing obstruction, heartburn, regurgitation of gastric acid for more than 2 months. An esophageal lesion was found by chest CT scans in T7 vertebral level. The diagnosis by gastroscopic biopsy was squamous cell carcinoma (SCC) with EGFR over-expression. Simultaneously, chest CT showed a 2 cm x 1 cm solitary lesion in the right superior pulmonary. The histological diagnosis by percutaneous lung Biopsy was “adenocarcinoma.” Epidermal growth factor receptor (EGFR) gene mutation status was evaluated by Sanger sequencing, and an exon 21 point mutation (L858R) was identified. When the double primary malignant tumors were diagnosed, the patient refused operation and received a tyrosine kinase inhibitor (TKI), icotinib, at the dose of 125 mg, three times per day. All serum tumor biomarkers such as CEA and cancer antigen 125 (CA125) were in the normal range during the treatment period. After five-year follow-up, the patient has no evidence of recurrence or metastasis. The lung cancer was stable, meanwhile the esophageal lesion was almost cured.ConclusionIcotininb is an effective treatment in the patients of the double primary malignant tumors of lung adenocarcinoma with EGFR gene mutation and esophageal squamous cell carcinoma with EGFR over-expression

Ubiquitin-Specific Peptidase 10 (USP10) Deubiquitinates and Stabilizes MutS Homolog 2 (MSH2) to Regulate Cellular Sensitivity to DNA Damage

MSH2 is a key DNA mismatch repair protein, which plays an important role in genomic stability. In addition to its DNA repair function, MSH2 serves as a sensor for DNA base analogs-provoked DNA replication errors and binds to various DNA damage-induced adducts to trigger cell cycle arrest or apoptosis. Loss or depletion of MSH2 from cells renders resistance to certain DNA-damaging agents. Therefore, the level of MSH2 determines DNA damage response. Previous studies showed that the level of MSH2 protein is modulated by the ubiquitin-proteasome pathway, and histone deacetylase 6 (HDAC6) serves as an ubiquitin E3 ligase. However, the deubiquitinating enzymes, which regulate MSH2 remain unknown. Here we report that ubiquitin-specific peptidase 10 (USP10) interacts with and stabilizes MSH2. USP10 deubiquitinates MSH2 in vitro and in vivo. Moreover, the protein level of MSH2 is positively correlated with the USP10 protein level in a panel of lung cancer cell lines. Knockdown of USP10 in lung cancer cells exhibits increased cell survival and decreased apoptosis upon the treatment of DNA-methylating agent N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) and antimetabolite 6-thioguanine (6-TG). The above phenotypes can be rescued by ectopic expression of MSH2. In addition, knockdown of MSH2 decreases the cellular mismatch repair activity. Overall, our results suggest a novel USP10-MSH2 pathway regulating DNA damage response and DNA mismatch repair

A three-dimensional (time, wavelength and intensity) functioning fluorescent probe for the selective recognition/discrimination of Cu2+, Hg2+, Fe3+ and F- ions

We have strategically incorporated three different fluorophores at tren to construct a multi-energy donor/acceptor “smart” probe L. This probe operates by using three-dimensional scales (response time, wavelength and fluorescence intensity) which allows for the selective recognition and discrimination of the Cu2+, Hg2+, Fe3+ and F− ions