The Synthesis and Strecker Reaction of 2‑Chlorotetrafluoroethanesulfinyl Ketimines

A series of 2-chlorotetrafluoroethanesulfinyl ketimines were prepared from 2-chlorotetrafluoroethanesulfinamide and ketones in high yields, and their Strecker reactions with TMSCN have been investigated. High yields and excellent diastereoselectivities were achieved in the presence of a catalytic amount of CsF under mild conditions. The six-membered chairlike models were proposed to account for the high stereoselective Strecker reaction

The characteristics of the patients with type 2 diabetes (N = 960).

<p>The characteristics of the patients with type 2 diabetes (N = 960).</p

The relationships between PACIC scores and different self-management behaviors (N = 960).

<p>The relationships between PACIC scores and different self-management behaviors (N = 960).</p

The relationships between PACIC and the most often utilized medical institutions for monitoring and treating diabetes among the patients with type 2 diabetes (N = 960).

<p>The relationships between PACIC and the most often utilized medical institutions for monitoring and treating diabetes among the patients with type 2 diabetes (N = 960).</p

The relationships between different self-management behaviors and glycemic control, and the relationships between PACIC and glycemic control (N = 960).

<p>The relationships between different self-management behaviors and glycemic control, and the relationships between PACIC and glycemic control (N = 960).</p

Label-Free Luminescent Switch-On Probe for Ochratoxin A Detection Using a G‑Quadruplex-Selective Iridium(III) Complex

A library of six luminescent Ir­(III) complexes were synthesized and studied for their capacity to function as probes for G-quadruplex DNA. The novel Ir­(III) complex <b>1</b> was discovered to be selective for G-quadruplex structures and was subsequently used for the construction of a label-free G-quadruplex-based ochratoxin A (OTA) sensing platform in aqueous solution. The assay exhibited linearity for OTA in the range of 0 to 60 nM (<i>R</i>² = 0.9933), and the limit of detection for OTA was 5 nM. Furthermore, this assay was highly selective for OTA over its structurally related analogues

Synthesis, characterization and <i>in vitro</i> antitumor behavior of a vanadium(V) complex with 4′-(3-methoxyphenyl)-2,2′:6′2″-terpyridine

<p>A dioxovanadium(V) complex, [VO₂(moptpy)](ClO₄) (<b>1</b>, moptpy = 4′-(3-methoxyphenyl)2,2′:6′2″-terpyridine), was synthesized and characterized by elemental analysis, ESI-MS, UV–vis, IR, and ¹H, ¹³C, and ⁵¹V NMR. The cytotoxicity <i>in vitro</i> of <b>1</b> was evaluated against cancer cell lines HepG-2 (hepatocellular carcinoma), SGC-7901 (gastric carcinoma), SiHa (cervical cancer), BEL-7402 (hepatocellular), and rat PC-12 (pheochromocytoma) by the MTT method. The results demonstrated that <b>1</b> exhibits superior anticancer activity <i>in vitro</i> with much lower values of 50% inhibitive concentration (IC₅₀) against the selected cell lines than cisplatin, and <b>1</b> shows the highest cytotoxic activity toward SGC-7901 cells (IC₅₀ = 1.3 ± 0.1 μM) among the selected cell lines. A series of cellular morphological and staining experiments were carried out, and the results indicated that <b>1</b> can effectively induce apoptosis of SGC-7901 cells through a ROS-mediated mitochondrial dysfunction pathway. In addition, cellular incorporation and cell cycle analysis were also performed, and it was concluded from the experimental observations that <b>1</b> can efficiently enter into the cell nuclei, and the complex inhibits cell growth in SGC-7901 cell at G0/G1 phase.</p

Characteristics of the Assays and Outcomes.

‡<p>Best cut-off;</p>¶<p>Mean</p

Association between elevated BNP and all cause mortality in patients with end stage renal disease, according to different study level characteristics.

<p>Association between elevated BNP and all cause mortality in patients with end stage renal disease, according to different study level characteristics.</p

Begg's funnel plots with 95% CI for BNP or NT-proBNP primary studies.

<p>Begg's funnel plots with 95% CI for BNP or NT-proBNP primary studies.</p