Liposome-Coated Persistent Luminescence Nanoparticles as Luminescence Trackable Drug Carrier for Chemotherapy

Near-infrared persistent luminescence nanoparticles (NIR-PLNPs) are promising imaging agents due to deep tissue penetration, high signal-to-noise ratio, and repeatedly charging ability. Here, we report liposome-coated NIR-PLNPs (Lipo-PLNPs) as a novel persistent luminescence imaging guided drug carrier for chemotherapy. The Lipo-PLNP nanocomposite shows the advantages of superior persistent luminescence and high drug loading efficiency and enables autofluorescence-free and long-term tracking of drug delivery carriers with remarkable therapeutic effect

Porphyrinic Metal–Organic Framework-Loaded Polycaprolactone Composite Films with a High Photodynamic Antibacterial Activity for the Preservation of Fresh-Cut Apples

Food-borne diseases caused by fresh fruits and vegetables seriously threaten human health. The polycaprolactone (PCL) polymer with good biodegradability has drawn growing interest in packaging and protecting of fresh fruits and vegetables. The disadvantage of pure PCL as a packaging material is the lack of the antibacterial function. Photodynamic sterilization as a safe and effective antibacterial method is now the emerging means for food safety. Therefore, the porphyrinic metal–organic framework MOF-545 as a highly effective photosensitizer was incorporated with PCL to prepare a biodegradable antibacterial composite film. The incorporation of MOF-545 nanorods significantly enhanced the hydrophilicity and mechanical strength of the film while slightly decreasing the transparency. The PCL/MOF-545 (10%) film exhibited the strongest antibacterial activity under a white LED light. This film was used for packaging fresh-cut apples and effectively killed 96% of the microorganisms, also delaying the apples’ discoloration and water loss. The PCL/MOF-545 film showed great potential for the antibacterial packaging of fruits and vegetables

Additional file 1 of Gut microbiota, circulating cytokines and dementia: a Mendelian randomization study

Additional file 1: The plots of MR analysis results

Activatable Multifunctional Persistent Luminescence Nanoparticle/Copper Sulfide Nanoprobe for in Vivo Luminescence Imaging-Guided Photothermal Therapy

Multifunctional nanoprobes that provide diagnosis and treatment features have attracted great interest in precision medicine. Near-infrared (NIR) persistent luminescence nanoparticles (PLNPs) are optimal materials due to no in situ excitation needed, deep tissue penetration, and high signal-to-noise ratio, while activatable optical probes can further enhance signal-to-noise ratio for the signal turn-on nature. Here, we show the design of an activatable multifunctional PLNP/copper sulfide (CuS)-based nanoprobe for luminescence imaging-guided photothermal therapy in vivo. Matrix metalloproteinases (MMPs)-specific peptide substrate (H₂N–GPLGVRGC–SH) was used to connect PLNP and CuS to build a MMP activatable system. The nanoprobe not only possesses ultralow-background for in vivo luminescence imaging due to the absence of autofluorescence and optical activatable nature but also offers effective photothermal therapy from CuS nanoparticles. Further bioconjugation of c­(RGDyK) enables the nanoprobe for cancer-targeted luminescence imaging-guided photothermal therapy. The good biocompatibility and the multiple functions of highly sensitive tumor-targeting luminescence imaging and effective photothermal therapy make the nanoprobe promising for theranostic application