Forrest plot for the association between rs861539 and radiation-induced late adverse effects by specific adverse effect.

<p>A fixed-effects model was used. The square with the corresponding horizontal line represents the OR and 95%CI of each study. The area of the square reflects the weight of the study. The diamond represents the pooled OR and 95%CI.</p

Forrest plot for the association between SNPs in <i>XRCC3</i> and radiation-induced adverse effects.

<p>A fixed-effects model was used. The square with the corresponding horizontal line represents the OR and 95%CI of each study. The area of the square reflects the weight of the study. The diamond represents the pooled OR and 95%CI.</p

Forrest plot for the effect of rs861539 on adverse effects induced by radiotherapy of different body areas.

<p>A fixed-effects model was used. The square with the corresponding horizontal line represents the OR and 95%CI of each study. The area of the square reflects the weight of the study. The diamond represents the pooled OR and 95%CI.</p

Forrest plot for the association between rs861539 and radiation-induced early adverse effects by specific adverse effect.

<p>A fixed-effects model was used. The square with the corresponding horizontal line represents the OR and 95%CI of each study. The area of the square reflects the weight of the study. The diamond represents the pooled OR and 95%CI.</p

Baseline Characteristics of the Eligible Studies.

<p>Abbreviations: HNC = head and neck cancer, RTOG = the radiation therapy oncology group, EORTC = European Organization for Research and Treatment of Cancer, EBRT = external beam radiation therapy, CTCAE = Common Terminology Criteria for Adverse Events. NA: not available</p><p>^a Breast cancer, HNC and meningioma;</p><p>^b Cervical cancer and endometrial cancer;</p><p>^c method based on CTCAE, in which G2c was defined as at least one moist desquamation or interruption of radiotherapy due to toxicity.</p><p>^d method developed by University of Michigan;</p><p>Baseline Characteristics of the Eligible Studies.</p

Flow diagram of the literature review process.

<p>Flow diagram of the literature review process.</p

Begg’s funnel plot for the effect of rs861539 on radiation-induced adverse effects.

<p>Circles represent the actually included studies. Squares represent studies added using the “trim and fill” method.</p

Additional file 1: Figure S1. of ERCC2 polymorphisms and radiation-induced adverse effects on normal tissue: systematic review with meta-analysis and trial sequential analysis

Begg’s funnel plot for the meta-analysis of rs13181. Supplementary material: The specific search strategy. (PDF 305 kb