Undifferentiated High-grade Pleomorphic Sarcoma (Malignant Fibrous Histiocytoma ) Occurring in the Nerve Root: A Rare Case Report and Review of the Literature

Introduction: undifferentiated pleomorphic sarcoma (UPS) represents a group of pleomorphic mesenchymal neoplasms without any defined cell differentiation, occurs more commonly in the extremities. However, we report a rare case of UPS, not malignant peripheral nerve sheath tumor (MPNST) in which the nerve root of the forth cervical vertebrae and adjacent tissues were involved. Presentation of Case: Histopathologically, this tumor was composed of highly atypical spindle cells, pleomorphic cells and multinucleated giant cells. Nuclear mitoses were frequently observed. Immunohistochemistrical results showed that the tumor cells stained positively for vimentin but negatively for all the other immunomarkers.Conclusion: We here reported an extremely rare case of UPS arising from the nerve root of the forth cervical vertebrae and proposed a hypothesis “tumors without any expression of neural markers should be diagnosed as UPSs, not MPNSTs, even though which may arise from peripheral nerve branches”

SheetCopilot: Bringing Software Productivity to the Next Level through Large Language Models

Computer end users have spent billions of hours completing daily tasks like tabular data processing and project timeline scheduling. Most of these tasks are repetitive and error-prone, yet most end users lack the skill to automate these burdensome works. With the advent of large language models (LLMs), directing software with natural language user requests become a reachable goal. In this work, we propose a SheetCopilot agent that takes natural language task and control spreadsheet to fulfill the requirements. We propose a set of atomic actions as an abstraction of spreadsheet software functionalities. We further design a state machine-based task planning framework for LLMs to robustly interact with spreadsheets. We curate a representative dataset containing 221 spreadsheet control tasks and establish a fully automated evaluation pipeline for rigorously benchmarking the ability of LLMs in software control tasks. Our SheetCopilot correctly completes 44.3\% of tasks for a single generation, outperforming the strong code generation baseline by a wide margin. Our project page:https://sheetcopilot.github.io/.Comment: Accepted to NeurIPS 202

Heavy metal induced ecophysiological function alterations in the euhalophyte Suaeda salsa

Heavy metal accumulation affects the physiological status of plants. Suaeda salsa L. is used to investigate the toxic effects of cadmium (Cd) and lead (Pb) either alone or mixtures under the static test conditions. Cd-Pb mixture exposure can decrease lignin content and weaken the increase. Mitochondrial calcium content significantly reduced at 30 µM Cd and Pb exposure. Cd-Pb mixture exposure can increase calcium content under the same concentration exposure. Soluble sugar levels noted a significant decrease in Cd, Pb and Cd-Pb mixture exposure. The accumulations of Cd, Pb in S. salsa were significantly increased with exposure time. Soluble protein (SP) in S. salsa at 30 µM concentration treatments decreased with exposure time. Heat shock protein 70 (HSP70) was enhanced lightly along with the increase of added Cd-Pb from 30 to 70 &3181;M and then decreased below the controls which present a synergistic effect. Heat shock protein 60 (HSP60) increased slightly with the increase of Cd-Pb from 30 to 110 µM, and then decreased hereafter and significantly inhibited at 150 ƒÊM (p<0.05). Moreover, Cd-Pb mixture exposure significantly increased the Rubisco activity under lower concentration and presented antagonistic effect. At the same time, the viability percent decreased as increase Cd-Pb concentration exposure (p0.05), it presents a dose-dependent manner. Mitochondrial cells treated with Cd-Pb exposure obviously reduced the reactive oxygen species (ROS) levels in mitochondrial cells.Key words: Suaeda salsa, heavy metal, ecophysiological function