389 research outputs found
The Complexity of Climate Positions of Right-wing Populist Parties in Europe
The rise of anti-climate right-wing populist parties urgently threatens mainstream climate governance goals in Europe. However, it is an oversimplification to portray all right-wing populist parties as outright climate deniers. In reality, the climate positions of right-wing populist parties are complex. While some right-wing populist parties continue to deny climate science and oppose climate action, others acknowledge the evidence but distance themselves from mainstream climate policies. This complexity arises from the tension between these parties’ ideological convictions and strategic considerations. On the optimistic side, the complexity of right-wing populist parties’ climate positions could create openings for cross-party cooperation based on scientific consensus and help transform some right-wing populist parties into constructive actors on climate governance. However, most right-wing populist parties remain deeply hostile to climate action; it is hard to expect that the opportunism of such parties in their climate positions will prompt them to make real policy concessions
A Study of Undercooling Behavior Of Immiscible Metal Alloys in the Absence of Crucible-Induced Nucleation
The purpose of this study is to investigate the question: Would eliminating the crucible eliminate the wall-induced nucleation of one of the liquid phases in an immiscible alloy and result in undercooling of the liquid into the metastable region thereby producing significant differences in the separation process and the microstructure upon solidification. Another primary objective of this research is to study systems with a metastable miscibility gap and to directly determine the metastable liquid miscibility gap by undercooling experiments. Nucleation and growth of droplets in these undercooled metallic liquid-liquid mixtures is also being studied. Results of this investigation indicate that containerless processing of immiscibles may not promote the undercooling of the single-phase liquid into the metastable region. Although no recalescence event was observed for this liquid-liquid transition, undercooling did occur across the miscibility gap for the solidification of the Ti phase that eventually separated
osmAG: Hierarchical Semantic Topometric Area Graph Maps in the OSM Format for Mobile Robotics
Maps are essential to mobile robotics tasks like localization and planning.
We propose the open street map (osm) XML based Area Graph file format to store
hierarchical, topometric semantic multi-floor maps of indoor and outdoor
environments, since currently no such format is popular within the robotics
community. Building on-top of osm we leverage the available open source editing
tools and libraries of osm, while adding the needed mobile robotics aspect with
building-level obstacle representation yet very compact, topometric data that
facilitates planning algorithms. Through the use of common osm keys as well as
custom ones we leverage the power of semantic annotation to enable various
applications. For example, we support planning based on robot capabilities, to
take the locomotion mode and attributes in conjunction with the environment
information into account. The provided C++ library is integrated into ROS. We
evaluate the performance of osmAG using real data in a global path planning
application on a very big osmAG map, demonstrating its convenience and
effectiveness for mobile robots.Comment: 7 page
Towards Nonlinear-Motion-Aware and Occlusion-Robust Rolling Shutter Correction
This paper addresses the problem of rolling shutter correction in complex
nonlinear and dynamic scenes with extreme occlusion. Existing methods suffer
from two main drawbacks. Firstly, they face challenges in estimating the
accurate correction field due to the uniform velocity assumption, leading to
significant image correction errors under complex motion. Secondly, the drastic
occlusion in dynamic scenes prevents current solutions from achieving better
image quality because of the inherent difficulties in aligning and aggregating
multiple frames. To tackle these challenges, we model the curvilinear
trajectory of pixels analytically and propose a geometry-based Quadratic
Rolling Shutter (QRS) motion solver, which precisely estimates the high-order
correction field of individual pixels. Besides, to reconstruct high-quality
occlusion frames in dynamic scenes, we present a 3D video architecture that
effectively Aligns and Aggregates multi-frame context, namely, RSA2-Net. We
evaluate our method across a broad range of cameras and video sequences,
demonstrating its significant superiority. Specifically, our method surpasses
the state-of-the-art by +4.98, +0.77, and +4.33 of PSNR on Carla-RS, Fastec-RS,
and BS-RSC datasets, respectively. Code is available at
https://github.com/DelinQu/qrsc.Comment: accepted at ICCV 202
ARF-BP1/Mule Is a Critical Mediator of the ARF Tumor Suppressor
SummaryAlthough the importance of the ARF tumor suppressor in p53 regulation is well established, numerous studies indicate that ARF also suppresses cell growth in a p53/Mdm2-independent manner. To understand the mechanism of ARF-mediated tumor suppression, we identified a ubiquitin ligase, ARF-BP1, as a key factor associated with ARF in vivo. ARF-BP1 harbors a signature HECT motif, and its ubiquitin ligase activity is inhibited by ARF. Notably, inactivation of ARF-BP1, but not Mdm2, suppresses the growth of p53 null cells in a manner reminiscent of ARF induction. Surprisingly, in p53 wild-type cells, ARF-BP1 directly binds and ubiquitinates p53, and inactivation of endogenous ARF-BP1 is crucial for ARF-mediated p53 stabilization. Thus, our study modifies the current view of ARF-mediated p53 activation and reveals that ARF-BP1 is a critical mediator of both the p53-independent and p53-dependent tumor suppressor functions of ARF. As such, ARF-BP1 may serve as a potential target for therapeutic intervention in tumors regardless of p53 status
Pharmacological targeting of gastric mucosal barrier with traditional Chinese medications for repairing gastric mucosal injury
Introduction: The gastric mucosa (GM) is the first barrier and vital interface in the stomach that protects the host from hydrochloric acid in gastric juice and defends against exogenous insults to gastric tissues. The use of traditional Chinese medications (TCMs) for the treatment of gastric mucosal injury (GMI) has long-standing history and a good curative effect. Whereas there are poor overall reports on the intrinsic mechanisms of these TCM preparations that pharmacology uses to protect body from GMI, which is crucial to treating this disease. These existing reviews have deficiencies that limit the clinical application and development of both customary prescriptions and new drugs.Methods: Further basic and translational studies must be done to elucidate the intrinsic mechanisms of influence of these TCM preparations. Moreover, well-designed and well-conducted experiences and clinical trials are necessary to ascertain the efficacy and mechanisms of these agents. Therefore, this paper presents a focused overview of currently published literature to assess how TCMs action that facilitates the cures for GMI. It offers a whole train of current state of pharmacological evidence, identifies the pharmacological mechanisms of TCMs on GM, and highlights that remarkable capacity of TCMs to restore GM after damage.Results: These TCMs preparations promote the repair of multicomponent targets such as the gastric mucus, epithelial layer, blood flow (GMBF) and lamina propria barrier.Summary: Overall, this study has summarized the essential regulatory mechanisms and pharmacological efficacy of TCMs on new and productive therapeutic targets.Discussion: This review provides an avenue for studying various drugs with potentially promising effects on mucosal integrity, as well as subsequent pharmacological studies, clinical applications, and new drug development
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