442 research outputs found
Codici di distillazione per la mitigazione dâattacchi di tipo Denial of Service in comunicazioni Multicast
Si descrivono dei codici di distillazione per la mitigazione degli effetti di un DoS nelle comunicazioni multicast. Si fa uso di una tecnica di signature amortization basata sul Merkle tree, ulteriormente ottimizzato. Le comunicazioni dei dati sono su multi-channel: si prevede uno scheduling adeguato dei pacchetti sui diversi canali
On the accuracy of the S/N estimates obtained with the exposure time calculator of the Wide Field Planetary Camera 2 on board the Hubble Space Telescope
We have studied the accuracy and reliability of the exposure time calculator
(ETC) of the Wide Field Planetary Camera 2 (WFPC2) on board the Hubble Space
Telescope (HST) with the objective of determining how well it represents actual
observations and, therefore, how much confidence can be invested in it and in
similar software tools. We have found, for example, that the ETC gives, in
certain circumstances, very optimistic values for the signal-to-noise ratio
(SNR) of point sources. These values overestimate by up to a factor of 2 the
HST performance when simulations are needed to plan deep imaging observations,
thus bearing serious implications on observing time allocation. For this
particular case, we calculate the corrective factors to compute the appropriate
SNR and detection limits and we show how these corrections vary with field
crowding and sky background. We also compare the ETC of the WFPC2 with a more
general ETC tool, which takes into account the real effects of pixel size and
charge diffusion. Our analysis indicates that similar problems may afflict
other ETCs in general showing the limits to which they are bound and the
caution with which their results must be taken.Comment: 14 pages, 13 figures, to be published in PASP on July 200
Interferometry of chemically peculiar stars: theoretical predictions vs. modern observing facilities
By means of numerical experiments we explore the application of
interferometry to the detection and characterization of abundance spots in
chemically peculiar (CP) stars using the brightest star eps~Uma as a case
study. We find that the best spectral regions to search for spots and stellar
rotation signatures are in the visual domain. The spots can clearly be detected
already at a first visibility lobe and their signatures can be uniquely
disentangled from that of rotation. The spots and rotation signatures can also
be detected in NIR at low spectral resolution but baselines longer than 180~m
are needed for all potential CP candidates. According to our simulations, an
instrument like VEGA (or its successor e.g., FRIEND) should be able to detect,
in the visual, the effect of spots and spots+rotation, provided that the
instrument is able to measure , and/or closure phase. In
infrared, an instrument like AMBER but with longer baselines than the ones
available so far would be able to measure rotation and spots. Our study
provides necessary details about strategies of spot detection and the
requirements for modern and planned interferometric facilities essential for CP
star research.Comment: Accepted by NMRAS, 18 pages, 11 figures, 2 table
SFADI: the Speckle-Free Angular Differential Imaging method
We present a new processing technique aimed at significantly improving the
angular differential imaging method (ADI) in the context of high-contrast
imaging of faint objects nearby bright stars in observations obtained with
extreme adaptive optics (EXAO) systems. This technique, named "SFADI" for
"Speckle-Free ADI", allows to improve the achievable contrast by means of
speckles identification and suppression. This is possible in very high cadence
data, which freeze the atmospheric evolution. Here we present simulations in
which synthetic planets are injected into a real millisecond frame rate
sequence, acquired at the LBT telescope at visible wavelength, and show that
this technique can deliver low and uniform background, allowing unambiguous
detection of contrast planets, from to mas separations,
under poor and highly variable seeing conditions ( to arcsec FWHM)
and in only min of acquisition. A comparison with a standard ADI approach
shows that the contrast limit is improved by a factor of . We extensively
discuss the SFADI dependence on the various parameters like speckle
identification threshold, frame integration time, and number of frames, as well
as its ability to provide high-contrast imaging for extended sources, and also
to work with fast acquisitions.Comment: Accepted for publication in Ap
De-biasing interferometric visibilities in VLTI-AMBER data of low SNR observations
AIMS: We have found that the interferometric visibilities of VLTI-AMBER
observations, extracted via the standard reduction package, are significantly
biased when faint targets are concerned. The visibility biases derive from a
time variable fringing effect (correlated noise) appearing on the detector.
METHODS: We have developed a method to correct this bias that consists in a
subtraction of the extra power due to such correlated noise, so that the real
power spectrum at the spatial frequencies of the fringing artifact can be
restored. RESULTS: This pre-processing procedure is implemented in a software,
called AMDC and available to the community, to be run before the standard
reduction package. Results obtained on simulated and real observations are
presented and discussed.Comment: 7 pages, 9 figure
Perimetrare il molteplice: la fabbricazione dellâumano nel VII libro della Naturalis historia di Plinio il Vecchio
Laddove in passato il VII libro della Naturalis historia era stato letto come un semplice accumulo caotico di informazioni, il presente contributo vuole invece individuare una logica sottesa a quella che eÌ la âfabbricazioneâ dellâumano in Plinio il Vecchio, il cui scopo non sembra tanto quello di definire una ousia, quanto piuttosto quello di disegnare unâantropologia anti-essenzialista ben lontana dai dettami del finalismo aristotelico, e definita dal perimetro vario e molteplice dei primati, degli eccessi, delle eccezioni che mostrano la prodigiosa creativitaÌ della Natura
Comparare lâincomparabile? Le prospettive 'proto-ecologicheâ sulla materia negli ultimi libri della Naturalis historia di Plinio il Vecchio
Come avviene per la chimica contemporanea, anche gli ultimi cinque libri della Naturalis historia di Plinio il Vecchio illustrano le proprietaÌ e il comportamento della materia, i cui elementi costitutivi non sono peroÌ atomi, molecole e ioni, bensiÌ â secondo una vulgata ormai divenuta egemone nel mondo antico â acqua, aria, fuoco, terra. La âchimicaâ, in particolare, eÌ, nella Naturalis historia, una âscienza della Terraâ, dei suoi frutti e â fuor di metafora â dei suoi stessi âvisceriâ, in un modello organicistico che vede nella Natura una divinitaÌ immanente e provvidenziale, che ora si concede spontaneamente alle applicazioni e agli usi degli umani, ora invece viene da essi violata. In questâottica, secondo la quale la Natura eÌ concepita come una sorta di âmadre-materia cosmicaâ, ogni pratica umana deve tenere conto della limitatezza delle risorse e delle conseguenze âmoraliâ dello sfruttamento delle stesse
On the binarity of the classical Cepheid X Sgr from interferometric observations
Optical-infrared interferometry can provide direct geometrical measurements
of the radii of Cepheids and/or reveal unknown binary companions of these
stars. Such information is of great importance for a proper calibration of
Period-Luminosity relations and for determining binary fraction among Cepheids.
We observed the Cepheid X Sgr with VLTI/AMBER in order to confirm or disprove
the presence of the hypothesized binary companion and to directly measure the
mean stellar radius, possibly detecting its variation along the pulsation
cycle. From AMBER observations in MR mode we performed a binary model fitting
on the closure phase and a limb-darkened model fitting on the visibility. Our
analysis indicates the presence of a point-like companion at a separation of
10.7 mas and 5.6 magK fainter than the primary, whose flux and position are
sharply constrained by the data. The radius pulsation is not detected, whereas
the average limb-darkened diameter results to be 1.48+/-0.08 mas, corresponding
to 53+/-3 R_sun at a distance of 333.3 pc.Comment: 5 pages, 3 figures, research not
Stavroula Pipyrou, The grecanici of southern Italy: Governance, violence, and minority politics, Philadelphia, University of Pennsylvania Press, 2016, pp. 246
Book review of Stavroula Pipyrou, The grecanici of southern Italy: Governance, violence, and minority politics, Philadelphia, University of Pennsylvania Press, 2016, pp. 246.Recensione di Stavroula Pipyrou, The grecanici of southern Italy: Governance, violence, and minority politics, Philadelphia, University of Pennsylvania Press, 2016, pp. 246
The role of CX3CR1 in pancreatic cancer
PhDPancreatic adenocarcinoma (PDAC) is the fourth leading cause of cancer death in Western countries. The PDAC tumour microenvironment (TME) is characterized by a dense stromal reaction, consisting of many cell types including fibroblasts and immune cells.
The chemokine receptor, CX3CR1 forms a high-affinity axis with its unique ligand CX3CL1 and is expressed on monocytes, macrophages and T cells. CX3CR1 is also present on pancreatic malignant cells, where it has been associated with metastasis formation.
The aim of my project is to investigate the role of CX3CR1 in the progression and development of pancreatic cancer in a genetically engineered mouse model of PDAC, the CX3CR1GFP/GFPLSL-KRASG12D/+LSL-Trp53R172H/+Pdx1-Cre (CKPC) mouse. In these mice, the CX3CR1 protein is not functional but they express GFP.
I have found that the absence of CX3CR1 in KPC mice has no effect in their lifespan and response to chemotherapy. Comparison of the immune infiltrate of the tumours revealed that the lack of CX3CR1 causes a significant decrease in T cells and a possible increase in myeloid cells in CKPC mice compared to KPC mice.
Expression analysis of several inflammatory cytokines in the TME showed a significant difference in IL-10 between KPC and CKPC mice. There was also a significant increase in levels of, CX3CL1, both locally and in the plasma.
Finally, we performed RNA-seq on KPC and CKPC tumours. My analysis revealed 607 differentially-expressed genes, some of which encoded other chemokines or protein regulating the immune system. In particular, I observed the upregulation of Cxcl10 and Cxcl12, and the downregulation of Gata3 and S100a4, which could explain the decrease in T cells in the TME of CKPC mice.
In conclusion, although the lack of CX3CR1 modifies the TME in this genetic model of PDAC, these changes do not affect the lifespan or the response to chemotherapy
- âŠ