12,397 research outputs found

    High-power single-mode operation in DFB and FP lasers using diffused quantum-well structure

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    Distributed feedback (DFB) and Fabry-Perot (FP) semiconductor lasers with step and periodic interdiffusion quantum-well structures are proposed for high-power single-longitudinal-mode operation. It is shown that the phase-adjustment region formed by the diffusion step (i.e., step change in optical gain and refractive index) counteracts the influence of spatial hole burning, especially for DFB lasers with large coupling-length products biased at high injection current. Furthermore, it is found that with careful design of the diffusion grating (i.e., grating period and amount of diffusion extent) of FP lasers, side-mode suppression ratio can be enhanced and threshold current density can be minimized to a satisfied level.published_or_final_versio

    Vertical-cavity surface-emitting semiconductor lasers with diffusedquantum wells

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    A self-consistent dynamic model is developed including the current distribution, carrier diffusion rate and spatial hole burning effects to investigate the modulation response of vertical-cavity surface-emitting lasers with diffused quantum wells structure. It is found that the overall performance including relaxation oscillation frequency and modulation bandwidth is improved.published_or_final_versio

    Fabry Perot semiconductor lasers with periodic diffused quantum wells structure

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    Fabry Perot semiconductor laser with periodic change in the extent of interdiffusion along the longitudinal direction of the quantum well active region is proposed to improve the discrimination between cavity modes.published_or_final_versio

    The Origin of Meridians

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    This article explores the origin of meridians. It suggests that the origin of meridians is closely related to the imageries derived by ancient physicians experiencing the circulation of Qi in their bodies during Qigong practice. Based on the cognitive experience from Qigong practice, as well as the symbolic analogy of the flow of rivers and the irrigation system of agriculture, the meridian theory has constructed a model of Qi and blood circulation. Such model is abstract and yet concrete, dialectic and yet intuitive, definite and yet vague, integrated and yet independent, having profound influence on the overall formation of traditional Chinese medicine theories.published_or_final_versio

    An intelligent knowledge processing system on hydrodynamics and water quality modeling

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    Series: Lecture notes in computer scienceAuthor name used in this publication: K. W. ChauAuthor name used in this publication: O. WaiAuthor name used in this publication: Y. S. Li2001-2002 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

    Preliminary study on assimilation of significant wave heights from T/P altimeter

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    2003-2004 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

    An inducible transgene expression system for regulated phenotypic modification of human embryonic stem cells

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    Self-renewing pluripotent human embryonic stem (hES) cells are capable of regenerating such non-dividing cells as neurons and cardiomyocytes for therapies and can serve as an excellent experimental model for studying early human development. Both the spatial and temporal relationships of gene expression play a crucial role in determining differentiation; to obtain a better understanding of hES cell differentiation, it will be necessary to establish an inducible system in hES cells that enables specific transgene(s) to reversibly and conditionally express (1) at specific levels and (2) at particular time points during development. Using lentivirus (LV)-mediated gene transfer and a tetracycline-controlled trans-repressor (TR), we first established in hES cells a doxycycline (DOX)-inducible expression system of green fluorescent protein (GFP) to probe its reversibility and kinetics. Upon the addition of DOX, the percentage of GFP + hES cells increased time dependently: The time at which 50% of all green cells appeared (T 50 on) was 119.5 ± 3.2 h; upon DOX removal, GFP expression declined with a half-time (T 50 off) of 127.7 ± 3.9 h and became completely silenced at day 8. Both the proportion and total mean fluorescence intensity (MFI) were dose-dependent (EC 50 = 24.5 ± 2.2 ng/ml). The same system when incorporated into murine (m) ES cells similarly exhibited reversible dose-dependent responses with a similar sensitivity (EC 50 =49.5 ± 8.5 ng/ml), but the much faster kinetics (T 50 on = 35.5 ± 5.5 h, T 50 off = 71.5 ± 2.4 hours). DOX-induced expression of the Kir2.1 channels in mES and hES cells led to robust expression of the inwardly rectifying potassium (K +) current and thereby hyperpolarized the resting membrane potential (RMP). We conclude that the LV-inducible system established presents a unique tool for probing differentiation. © 2008 Mary Ann Liebert, Inc.published_or_final_versio
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