Harnessing motivation to alleviate neglect

This article is made available through the Brunel Open Access Publishing Fund. Copyright: © 2013 Russell, Li and Malhotra. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.The syndrome of spatial neglect results from the combination of a number of deficits in attention, with patients demonstrating both spatially lateralized and non-lateralized impairments. Previous reports have hinted that there may be a motivational component to neglect and that modulating this might alleviate some of the debilitating symptoms. Additionally, recent work on the effects of reward on attention in healthy participants has revealed improvements across a number of paradigms. As the primary deficit in neglect has been associated with attention, this evidence for reward's effects is potentially important. However, until very recently there have been few empirical studies addressing this potential therapeutic avenue. Here we review the growing body of evidence that attentional impairments in neglect can be reduced by motivation, for example in the form of preferred music or anticipated monetary reward, and discuss the implications of this for treatments for these patients. Crucially these effects of positive motivation are not observed in all patients with neglect, suggesting that the consequences of motivation may relate to individual lesion anatomy. Given the key role of dopaminergic systems in motivational processes, we suggest that motivational stimulation might act as a surrogate for dopaminergic stimulation. In addition, we consider the relationship between clinical post stroke apathy and lack of response to motivation

Convolutional compressed sensing using deterministic sequences

This is the author's accepted manuscript (with working title "Semi-universal convolutional compressed sensing using (nearly) perfect sequences"). The final published article is available from the link below. Copyright @ 2012 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works.In this paper, a new class of orthogonal circulant matrices built from deterministic sequences is proposed for convolution-based compressed sensing (CS). In contrast to random convolution, the coefficients of the underlying filter are given by the discrete Fourier transform of a deterministic sequence with good autocorrelation. Both uniform recovery and non-uniform recovery of sparse signals are investigated, based on the coherence parameter of the proposed sensing matrices. Many examples of the sequences are investigated, particularly the Frank-Zadoff-Chu (FZC) sequence, the m-sequence and the Golay sequence. A salient feature of the proposed sensing matrices is that they can not only handle sparse signals in the time domain, but also those in the frequency and/or or discrete-cosine transform (DCT) domain

Evolutionary L∞ identification and model reduction for robust control

An evolutionary approach for modern robust control oriented system identification and model reduction in the frequency domain is proposed. The technique provides both an optimized nominal model and a 'worst-case' additive or multiplicative uncertainty bounding function which is compatible with robust control design methodologies. In addition, the evolutionary approach is applicable to both continuous- and discrete-time systems without the need for linear parametrization or a confined problem domain for deterministic convex optimization. The proposed method is validated against a laboratory multiple-input multiple-output (MIMO) test rig and benchmark problems, which show a higher fitting accuracy and provides a tighter L�¢���� error bound than existing methods in the literature do

Process feasibility study in support of silicon material, task 1

Analyses of process system properties were continued for materials involved in the alternate processes under consideration for semiconductor silicon. Primary efforts centered on physical and thermodynamic property data for dichlorosilane. The following property data are reported for dichlorosilane which is involved in processing operations for solar cell grade silicon: critical temperature, critical pressure, critical volume, critical density, acentric factor, vapor pressure, heat of vaporization, gas heat capacity, liquid heat capacity and density. Work was initiated on the assembly of a system to prepare binary gas mixtures of known proportions and to measure the thermal conductivity of these mixtures between 30 and 350 C. The binary gas mixtures include silicon source material such as silanes and halogenated silanes which are used in the production of semiconductor silicon

On solutions to the non-Abelian Hirota-Miwa equation and its continuum limits

In this paper, we construct grammian-like quasideterminant solutions of a non-Abelian Hirota-Miwa equation. Through continuum limits of this non-Abelian Hirota-Miwa equation and its quasideterminant solutions, we construct a cascade of noncommutative differential-difference equations ending with the noncommutative KP equation. For each of these systems the quasideterminant solutions are constructed as well.Comment: 9 pages, 1 figur

Extremal covariant POVM's

We consider the convex set of positive operator valued measures (POVM) which are covariant under a finite dimensional unitary projective representation of a group. We derive a general characterization for the extremal points, and provide bounds for the ranks of the corresponding POVM densities, also relating extremality to uniqueness and stability of optimized measurements. Examples of applications are given.Comment: 15 pages, no figure

Reward modulates spatial neglect

Copyright @ 2012 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and 85 reproduction in any medium, provided the original author and source are credited. The article was made available through the Brunel University Open Access Publishing Fund.BACKGROUND: Reward has been shown to affect attention in healthy individuals, but there have been no studies addressing whether reward influences attentional impairments in patients with focal brain damage. METHODS: Using two novel variants of a widely-used clinical cancellation task, we assessed whether reward modulated impaired attention in 10 individuals with left neglect secondary to right hemisphere stroke. RESULTS: Reward exposure significantly reduced neglect, as measured by total targets found, left-sided targets found and centre of cancellation, across the patient group. Lesion analysis showed that lack of response to reward was associated with damage to the ipsilateral striatum. CONCLUSIONS: This is the first experimental evidence that reward can modulate attentional impairments following brain damage. These results have significant implications for the development of behavioural and pharmacological therapies for patients with attentional disorders.PM is supported by a HEFCE Clinical Senior Lectureship Award and this research was funded by grants from the UK Academy of Medical Sciences/Wellcome Trust and the NIHR Biomedical Research Centre at Imperial College London. DS is supported by a grant from the UK Medical Research Council (89631). CR is supported by a Brunel Research Initiative Award (BRIEF) and a scientific bursary from the Bial foundation, Portugal

Superior removal of arsenic from water with zirconium metal-organic framework UiO-66

10.1038/srep16613Scientific Reports51661