Intense keV isolated attosecond pulse generation by orthogonally polarized multicycle midinfrared two-color laser field

We theoretically investigate the generation of intense keV attosecond pulses in an orthogonally polarized multicycle midinfrared two-color laser field. It is demonstrated that multiple continuum-like humps, which have a spectral width of about twenty orders of harmonics and an intensity of about one order higher than adjacent normal harmonic peaks, are generated under proper two-color delays, owing to the reduction of the number of electron-ion recollisions and suppression of inter-half-cycle interference effect of multiple electron trajectories when the long wavelength midinfrared driving field is used. Using the semiclassical trajectory model, we have revealed the two-dimensional manipulation of the electron-ion recollision process, which agrees well with the time frequency analysis. By filtering these humps, intense isolated attosecond pulses are directly generated without any phase compensation. Our proposal provides a simple technique to generate intense isolated attosecond pulses with various central photon energies covering the multi-keV spectral regime by using multicycle driving pulses with high pump energy in experiment.Comment: 11 pages,5 figures, research articl

The hidden moderator – Exploring the roles of tuo’er in intra-firm R&D online communities

“Tuo’er” in a market place are those who are hired by a seller and attempt to push the sales by exaggerating the advantages of a product in a direct and persistent approach. More recently, it is to our observation that some large firms start deploying tuo’er on their intranet to facilitate knowledge sharing and innovation within intra-firm online R&D communities. Just like those in a market place, tuo’er in online knowledge shari ng communities also have a mandate to mislead other regular community members by creating a bandwagon effect. However, their intention to facilitate online knowledge sharing an d innovation within a firm might serve a good purpose and their practice stands in a gray area of management ethics. This study explores the special roles of tuo’er as a hidden moderator between a company and its employees, investigates under which conditions they work, and the implications for the effective use of online knowledge sharing communiti es by firms. An in-depth case study with multiple data sources is conducted in China in a longitudinal fashion

Human Cytomegalovirus Encoded miR-US25-1-5p Attenuates CD147/EMMPRIN-Mediated Early Antiviral Response.

Cellular receptor-mediated signaling pathways play critical roles during the initial immune response to Human Cytomegalovirus (HCMV) infection. However, the involvement of type-I transmembrane glycoprotein CD147/EMMPRIN (extracellular matrix metalloproteinase inducer) in the antiviral response to HCMV infection is still unknown. Here, we demonstrated the specific knockdown of CD147 significantly decreased HCMV-induced activation of NF-κB and Interferon-beta (IFN-β), which contribute to the cellular antiviral responses. Next, we confirmed that HCMV-encoded miR-US25-1-5p could target the 3 UTR (Untranslated Region) of CD147 mRNA, and thus facilitate HCMV lytic propagation at a low multiplicity of infection (MOI). The expression and secretion of Cyclophilin A (sCyPA), as a ligand for CD147 and a proinflammatory cytokine, were up-regulated in response to HCMV stimuli. Finally, we confirmed that CD147 mediated HCMV-triggered antiviral signaling via the sCyPA-CD147-ERK (extracellular regulated protein kinases)/NF-κB axis signaling pathway. These findings reveal an important HCMV mechanism for evading antiviral innate immunity through its encoded microRNA by targeting transmembrane glycoprotein CD147, and a potential cause of HCMV inflammatory disorders due to the secretion of proinflammatory cytokine CyPA

Waveform-Controlled Terahertz Radiation from the Air Filament Produced by Few-Cycle Laser Pulses

Waveform-controlled Terahertz (THz) radiation is of great importance due to its potential application in THz sensing and coherent control of quantum systems. We demonstrated a novel scheme to generate waveform-controlled THz radiation from air plasma produced when carrier-envelope-phase (CEP) stabilized few-cycle laser pulses undergo filamentation in ambient air. We launched CEP-stabilized 10 fs-long (~ 1.7 optical cycles) laser pulses at 1.8 {\mu}m into air and found that the generated THz waveform can be controlled by varying the filament length and the CEP of driving laser pulses. Calculations using the photocurrent model and including the propagation effects well reproduce the experimental results, and the origins of various phase shifts in the filament are elucidated.Comment: 5pages, 5 figure

Direct evidences for inner-shell electron-excitation by laser induced electron recollision

Extreme ultraviolet (XUV) attosecond pulses, generated by a process known as laser-induced electron recollision, are a key ingredient for attosecond metrology, providing a tool to precisely initiate and probe sub-femtosecond dynamics in the microcosms of atoms, molecules and solids[1]. However, with the current technology, extending attosecond metrology to scrutinize the dynamics of the inner-shell electrons is a challenge, that is because of the lower efficiency in generating the required soft x-ray \hbar\omega>300 eV attosecond bursts and the lower absorption cross-sections in this spectral range. A way around this problem is to use the recolliding electron to directly initiate the desired inner-shell process, instead of using the currently low flux x-ray attosecond sources.Such an excitation process occurs in a sub-femtosecond timescale, and may provide the necessary "pump" step in a pump-probe experiment[2]. Here we used a few cycle infrared \lambda_{0}~1800nm source[3] and observed direct evidences for inner-shell excitations through the laser-induced electron recollision process. It is the first step toward time-resolved core-hole studies in the keV energy range with sub-femtosecond time resolution.Comment: 6 pages, 4 figure

Measure pseudo affine-periodic solutions of semilinear differential equations

n this paper, we introduce the concept of pseudo affine-periodic functionvia measure theory, that is measure pseudo (Q, T)-affine-periodic function.Existence, uniqueness of measure pseudo (Q, T)-affine-periodic solutionfor semilinear differential equations are investigated.The working tools are based on the Banach contraction mapping principleand Leray-Schauder alternative theorem.Finally, an example is presented to illustrate the main findings