An Architecture of FoaF-based Peer 2 Peer Knowledge Management System

A number of researches have been focused on improving the productivity of knowledge workers. Effective communication is determinative, and one important problem has been to find the right person for collaboration. The Semantic Web efforts improve it by better wide-range knowledge management. Through extending the FoaF (Friend of a Friend) vocabulary, knowledge workers can share their machine-readable knowledge world widely, so that their PCs can facilitate effective collaboration efficiently. This paper presents an approach to support networked personal knowledge management. An example of extended FoaF is also describe

In Situ Growth of Mg-Fe Layered Double Hydroxides (LDH) Film on Titanium Dental Implant Substrates for pH Regulation in Oral Environments

Layered double hydroxides (LDHs) consist of two-dimensional, positively charged lamellar structures with the ability to host various anions in the interlayer spaces, which grants them unique properties and tunable characteristics. LDHs, a class of versatile inorganic compounds, have recently emerged as promising candidates for enhancing osseointegration. A suitable alkaline microenvironment is thought to be beneficial for stimulating osteoblasts’ differentiation (responsible for bone matrix formation) while suppressing osteoclast generation (responsible for bone matrix disintegration). LDHs are prone to adjusting their alkalinity and thus offering us the chance to study how pH affects cellular behavior. LDHs can indeed modulate the local pH, inflammatory responses, and oxidative stress levels, factors that profoundly influence the behavior of osteogenic cells and their interactions with the implant surface. Herein, we deposited Mg–Fe LDH films on titanium substrates for dental implants. The modified Ti substrates was more alkaline in comparison to the bare ones, with a pH higher than 8 after hydrolysis in an aqueous environment

Cultivation of Paeoniae radix rubra in the wild-like environment and the evaluation of quality for transplanted products

Aim: The study aims to guide the actual cultivation of Paeonia lactiflora Pall. By establishing indoor and outdoor imitation wild environment, meanwhile, it used the quality inspection of cultivated production to judge the rationality of the scheme. Method: The seeds and rhizomes of Paeonia lactiflora P. were collected in the autumn of 2014, and the seed germination rate was tested under indoor wild-like conditions. In the outdoor wild-like environment, the buds were transplanted, then the roots were harvested in 2016, 2017, and 2018, respectively. Quantitative determination of paeoniflorin was determined by HPLC. Furthermore, the data on trait determination and component content were compared and analyzed.Results: In the specific indoor environment, the seeds were normally germinated, and their functions consisted of seed in wild regions. Moreover, the content of paeoniflorin in both two sources of Paeonia lactiflora P. roots, and the traits of cultivated products are increasing year by year.Conclusion: The simulated wild environment established the method in this study, which is suitable for the artificial production of wild Paeonia lactiflora P

The Pro12Ala Polymorphism of PPAR- γ

Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-binding nuclear receptor, and its activation plays a prominent role in regulating the inflammatory response. Therefore, PPAR-γ has been suggested as a candidate gene for sepsis. In the present study, we investigated the association between the Pro12Ala polymorphism of PPAR-γ and sepsis in a Han Chinese population. A total of 308 patients with sepsis and 345 healthy controls were enrolled in this study. Genotyping was performed using the polymerase chain reaction-ligation detection reaction (PCR-LDR) method. No significant differences were detected in the allele and genotype distributions of the PPAR-γ Pro12Ala SNP between septic patients and controls (P=0.622 for genotype; P=0.629 for allele). However, stratification by subtypes (sepsis, septic shock, and severe sepsis) revealed a statistically significant difference in the frequency of the Ala allele and Ala-carrier genotype between the patients with the sepsis subtype and the healthy controls (P=0.014 for allele and P=0.012, for genotype). Moreover, significant differences were found in the frequency of the Ala allele and genotype between the sepsis survivors and nonsurvivors (all P=0.002). In the survivors, the PPAR-γ Pro12Ala genotype was significantly associated with decreased disease severity and recovery time (all P<0.001). Thus, genetic polymorphism is thought to play a role in the development and outcome of sepsis

Zn&ndash;Al Layered Double Hydroxides Synthesized on Aluminum Foams for Fluoride Removal from Water

Fluoride excess in water represents an environmental issue and a risk for human health since it can cause several diseases, such as fluorosis, osteoporosis, and damage of the nervous system. Layered double hydroxides (LDHs) can be exploited to remove this contaminant from water by taking advantage of their high ion-exchange capability. LDHs are generally mixed with polluted water in the form of powders, which then cause the problem of uneasy separation of the contaminated LDH sludge from the purified liquid. In this work, Zn&ndash;Al LDH films were directly grown in situ on aluminum foams that acted both as the reactant and substrate. This method enabled the removal of fluoride ions by simple immersion, with ensuing withdrawal of the foam from the de-contaminated water. Different LDH synthesis methods and aluminum foam types were investigated to improve the adsorption process. The contact time, initial fluoride concentration, adsorbent dosage, and pH were studied as the parameters that affect the fluoride adsorption capacity and efficiency. The highest absorption efficiency of approximately 70% was obtained by using two separate growth methods after four hours, and it effectively reduced the fluoride concentration from 3 mg/L to 1.1 mg/L, which is below the threshold value set by WHO for drinking water

A New Optical Method for Quantitative Detection of Microplastics in Water Based on Real-Time Fluorescence Analysis

Microplastics (MPs) have recently emerged as a new major and ubiquitous environmental pollutant with still undefined, yet potentially high risks for human health and ecosystems. This has prompted growing public concern along with an increasing number of scientific studies. In particular, recent research has highlighted the need for a standardized methodology to monitor microplastics in different media, particularly in water. This study reports on the use of a new particle counter for the quantitative detection of MPs in water samples based on real-time analysis of fluorescence emissions. The instrument was calibrated using two types of plastic particles, i.e., polyvinyl chloride and high-density polyethylene, selected as examples of high- and low-density plastics, respectively. Specific solvents were used to match the different plastic densities. Measurements were also carried out on particles obtained from wastewater samples collected at the inlet and outlet of specific units of a municipal wastewater treatment plant after sieving, filtering, digestion with hydrogen peroxide to remove degradable organic matter and resuspension in the solvents employed during the calibration step. A Fourier transform infrared spectroscopy analysis performed on the same wastewater samples confirmed the presence of MPs, and, in particular, of polyethylene, in some of the samples in which the highest concentrations were measured applying the proposed method. Therefore, the novel particle counter described in this paper could represent a promising method to quantitatively measure MP concentrations in water samples

Hydrocarbon accumulation history in Lower Cretaceous in northern slope of Bongor Basin in Chad, Central Africa

Based on the analysis of the fluid inclusion homogenization temperature and apatite fission track on the northern slope zone of the Bongor Basin in Chad, this paper studied the time and stages of hydrocarbon accumulation in the study area. The results show that: (1) The brine inclusions of the samples from the Kubla and Prosopis formations in the Lower Cretaceous coexisting with the hydrocarbon generally present two sets of peak ranges of homogenization temperature, with the peak ranges of low temperature and high temperature being 75–105 °C and 115–135 °C, respectively; (2) The samples from the Kubla and Prosopis formations have experienced five tectonic evolution stages, i.e., rapid subsidence in the Early Cretaceous, tectonic inversion in the Late Cretaceous, small subsidence in the Paleogene, uplift at the turn of the Paleogene and Neogene, and subsidence since the Miocene, in which the denudation thickness of the Late Cretaceous and after the turn of the Paleogene and Neogene are ~1.8 km and ~0.5 km, respectively. The cumulative denudation thickness of the two periods is about 2.3 km; (3) Using the brine inclusion homogenization temperature coexisting with the hydrocarbon as the capture temperature of the hydrocarbon, and combining with the apatite fission track thermal history modeling, the result shows that the Kubla and Prosopis formations in the Lower Cretaceous on the northern slope of the Bongor Basin have the same hydrocarbon accumulation time and stages, both of which have undergone two stages of hydrocarbon charging at 80–95 Ma and 65–80 Ma. The first stage of charging corresponds to the initial migration of hydrocarbon at the end of the Early Cretaceous rapid sedimentation, while the second stage of charging is in the stage of intense tectonic inversion in the Late Cretaceous

A functional polymorphism in the promoter region of microRNA-146a is associated with the risk of Alzheimer disease and the rate of cognitive decline in patients.

miR146a is well known for its regulatory role in the immune response and inflammation. Recent studies have demonstrated the links between miR146a and Alzheimer disease (AD) and suggested that miR146a may be involved in neuroinflammation and the metabolism of amyloid-β (Aβ), which are critical events in AD pathology. Although genetic studies have focused on the association between the miR146a gene and susceptibility to several diseases, no association study of miR146a variability with AD has been conducted. In this report, we performed a case-control association study to analyze the genotype and allele distributions of the miR146a, rs2910464 and rs57095329 polymorphisms in a Chinese population consisting of 292 AD cases and 300 healthy controls. We found a significant difference in the genotypes and allele frequencies of rs57095329 between the AD cases and the controls (p = 0.0147 and p = 0.0184, respectively), where the AA genotype of rs57095329 was associated with an increased risk of AD as well the cognitive decline in AD patients. Additionally, the AA genotype of rs57095329 exhibited significantly higher miR146a expression than the GG+GA genotypes of rs2910164 in the peripheral blood cells (PBMCs) of healthy individuals and had a stronger effect on the production of IL-6 and IL-1β when the cells were stimulated with LPS. Our data provide preliminary evidence that the rs57095329 polymorphism in the miR146a promoter is involved in the genetic susceptibility to AD, and this risk AA genotype may increase the expression of miR146a and influence certain proinflammatory cytokines, thus playing a role in the pathogenesis of AD

The Functional Polymorphisms of miR-146a Are Associated with Susceptibility to Severe Sepsis in the Chinese Population

MicroRNA-146a (miR-146a) acts as a pivotal regulatory molecule in immune response and various diseases, such as carcinoma and autoimmune diseases. Growing evidences have demonstrated the association of miR-146a gene single-nucleotide polymorphisms (SNPs) with risk of several diseases, but no genetic relevance studies of miR-146a gene polymorphisms to sepsis have been reported by now. Our study has analyzed the association of sepsis with two functional miR-146a gene SNPs rs2910164 G/C and rs57095329 A/G in a Chinese Han population (226 sepsis cases; 206 healthy controls). Our results indicated a higher prevalence of the miR-146a gene SNP rs2910164 C allele and CC genotype in patients with severe sepsis (rs2910164G versus rs2910164C: P = 0.0029, odds ratio (OR) = 1.664; GG+GC versus CC: P = 0.0045, OR = 1.947). Neither the genotype nor the allele in rs57095329 showed significant differences between the septic cases and the controls (P = 0.5901 and 0.3580, resp.), and no significant difference was observed in the subgroups. In addition, we confirmed that the two SNPs rs2910164 and rs57095329 could functionally affect the miR-146a expression levels and the reduction of miR146a was accompanied with the upregulation of the expression levels of TRAF-6 and IRAK-1 in severe sepsis patients. This present study might provide valuable clinical evidence that miR-146a gene polymorphism rs2910164 is associated with the risk of severe sepsis