A Large-field J=1-0 Survey of CO and Its Isotopologues Toward the Cassiopeia A Supernova Remnant

We have conducted a large-field simultaneous survey of $^{12}$CO, $^{13}$CO, and C$^{18}$O $J=1-0$ emission toward the Cassiopeia A (Cas A) supernova remnant (SNR), which covers a sky area of $3.5^{\circ}\times3.1^{\circ}$. The Cas giant molecular cloud (GMC) mainly consists of three individual clouds with masses on the order of $10^4-10^5\ M_{\odot}$. The total mass derived from the $\rm{^{13}CO}$ emission of the GMC is 2.1$\times10^{5}\ M_{\odot}$ and is 9.5$\times10^5\ M_{\odot}$ from the $\rm{^{12}CO}$ emission. Two regions with broadened (6$-$7 km s$^{-1}$) or asymmetric $^{12}$CO line profiles are found in the vicinity (within a 10$'\times10'$ region) of the Cas A SNR, indicating possible interactions between the SNR and the GMC. Using the GAUSSCLUMPS algorithm, 547 $^{13}$CO clumps are identified in the GMC, 54$\%$ of which are supercritical (i.e. $\alpha_{\rm{vir}}<2$). The mass spectrum of the molecular clumps follows a power-law distribution with an exponent of $-2.20$. The pixel-by-pixel column density of the GMC can be fitted with a log-normal probability distribution function (N-PDF). The median column density of molecular hydrogen in the GMC is $1.6\times10^{21}$ cm$^{-2}$ and half the mass of the GMC is contained in regions with H$_2$ column density lower than $3\times10^{21}$ cm$^{-2}$, which is well below the threshold of star formation. The distribution of the YSO candidates in the region shows no agglomeration.Comment: 24 pages, 18 figure

LSTM Deep Neural Network Based Power Data Credit Tagging Technology

The value of power data credit reporting in the social credit system continues to increase, and the government, users and the whole society have deep expectations and support for power data credit reporting. This paper will combine the data labeling theory as the support, define the power data label and explain its labeling implementation. Based on the construction of knowledge graph, the method of labeling power data is introduced in detail: demand analysis method, index selection method, data cleaning method and data desensitization method. Use the sorted data labels to establish a label system for power data, and through its system, visualize the comprehensive situation of enterprise power data credit information to meet the development of power data credit business. This paper takes shell enterprises as the main representatives of credit risk enterprises, analyzes the power data in the three stages before and after loans, and builds a value mining model for power credit data. In the future, the data labeling technology and value mining model of the power data credit business will be comprehensively applied, and the power data label library and credit model library will be established and continuously improved, so as to facilitate the evaluation of the operation of the enterprise at different stages

A Survey of Methods for Handling Disk Data Imbalance

Class imbalance exists in many classification problems, and since the data is designed for accuracy, imbalance in data classes can lead to classification challenges with a few classes having higher misclassification costs. The Backblaze dataset, a widely used dataset related to hard discs, has a small amount of failure data and a large amount of health data, which exhibits a serious class imbalance. This paper provides a comprehensive overview of research in the field of imbalanced data classification. The discussion is organized into three main aspects: data-level methods, algorithmic-level methods, and hybrid methods. For each type of method, we summarize and analyze the existing problems, algorithmic ideas, strengths, and weaknesses. Additionally, the challenges of unbalanced data classification are discussed, along with strategies to address them. It is convenient for researchers to choose the appropriate method according to their needs

Combined abdominal heterotopic heart and aorta transplant model in mice

BACKGROUND: Allograft vasculopathy (AV) remains a major obstacle to long-term allograft survival. While the mouse aortic transplantation model has been proven as a useful tool for study of the pathogenesis of AV, simultaneous transplantation of the aorta alongside the transplantation of another organ may reveal more clinically relevant mechanisms that contribute to the pathogenesis of chronic allograft rejection. Therefore, we developed a combined abdominal heart and aorta transplantation model in mice which benefits from reducing animal and drug utilization, while providing an improved model to study the progressive nature of AV. METHODS: The middle of the infrarenal aorta of the recipient mouse was ligatured between the renal artery and its bifurcation. Proximal and distal aortotomies were performed at this site above and below the ligature, respectively, for the subsequent anastomoses of the donor aorta and heart grafts to the recipient infrarenal aorta in an end-to-side fashion. The distal anastomotic site of the recipient infrarenal aorta was connected with the outlet of the donor aorta. Uniquely, the proximal anastomotic site on the recipient infrarenal aorta was shared to connect with both the inlet of the donor aorta and the inflow tract to the donor heart. The outflow tract from the donor heart was connected to the recipient inferior vena cava (IVC). RESULTS: The median times for harvesting the heart graft, aorta graft, recipient preparation and anastomosis were 11.5, 8.0, 9.0 and 40.5 min, respectively, resulting in a total median ischemic time of 70 min. The surgery survival rate was more than 96% (29/30). Both the syngeneic C57Bl/6 aorta and heart grafts survived more than 90 days in 29 C57Bl/6 recipients. Further, Balb/c to C57Bl/6 allografts treated with anti-CD40L and CTLA4.Ig survived more than 90 days with a 100% (3/3) survival rate. (3/3). CONCLUSIONS: This model is presented as a new tool for researchers to investigate transplant immunology and assess immunosuppressive strategies. It is possible to share a common anastomotic stoma on the recipient abdominal aorta to reconstruct both the aorta graft entrance and heart graft inflow tract. This allows for the study of allogeneic effects on both the aorta and heart from the same animal in a single survival surgery

Combined abdominal heterotopic heart and aorta transplant model in mice

BACKGROUND: Allograft vasculopathy (AV) remains a major obstacle to long-term allograft survival. While the mouse aortic transplantation model has been proven as a useful tool for study of the pathogenesis of AV, simultaneous transplantation of the aorta alongside the transplantation of another organ may reveal more clinically relevant mechanisms that contribute to the pathogenesis of chronic allograft rejection. Therefore, we developed a combined abdominal heart and aorta transplantation model in mice which benefits from reducing animal and drug utilization, while providing an improved model to study the progressive nature of AV. METHODS: The middle of the infrarenal aorta of the recipient mouse was ligatured between the renal artery and its bifurcation. Proximal and distal aortotomies were performed at this site above and below the ligature, respectively, for the subsequent anastomoses of the donor aorta and heart grafts to the recipient infrarenal aorta in an end-to-side fashion. The distal anastomotic site of the recipient infrarenal aorta was connected with the outlet of the donor aorta. Uniquely, the proximal anastomotic site on the recipient infrarenal aorta was shared to connect with both the inlet of the donor aorta and the inflow tract to the donor heart. The outflow tract from the donor heart was connected to the recipient inferior vena cava (IVC). RESULTS: The median times for harvesting the heart graft, aorta graft, recipient preparation and anastomosis were 11.5, 8.0, 9.0 and 40.5 min, respectively, resulting in a total median ischemic time of 70 min. The surgery survival rate was more than 96% (29/30). Both the syngeneic C57Bl/6 aorta and heart grafts survived more than 90 days in 29 C57Bl/6 recipients. Further, Balb/c to C57Bl/6 allografts treated with anti-CD40L and CTLA4.Ig survived more than 90 days with a 100% (3/3) survival rate. (3/3). CONCLUSIONS: This model is presented as a new tool for researchers to investigate transplant immunology and assess immunosuppressive strategies. It is possible to share a common anastomotic stoma on the recipient abdominal aorta to reconstruct both the aorta graft entrance and heart graft inflow tract. This allows for the study of allogeneic effects on both the aorta and heart from the same animal in a single survival surgery