The Trend of Scientific and Refinement of Financial Management in Business Units

In the new era, financial management has become increasingly sophisticated and has had a significant impact and change on various industries and fields. This paper analyzes the key significance of performance appraisal in institutions and proposes ways to enhance performance appraisal innovation, which will prevail in financial management innovation in institutions and upgrade the value of its applications

Rescuing Infertility of Pick1 Knockout Mice by Generating Testis-specific Transgenic Mice via Testicular Infection

PICK1 (protein interacting with C-kinase 1) is a peripheral membrane protein with high expression in brain, testis, pancreas and other neuroendocrine tissues. Male Pick1 knockout mice are completely infertile, with a phenotype resembling the human disease globozoospermia. Since PICK1 is expressed in both testis and neuroendocrine tissues, infertility of Pick1 knockout mice may be due to either impaired neuroendocrine function or abnormal spermatogenesis. To distinguish these two possibilities, we restored PICK1's expression in the testis by seminiferous tubule microinjection of PICK1-containing lentivirus. By examining the testis-specific Pick1 transgenic mice, we found that PICK1's expression in testis rescued the spermatogenic abnormalities and male infertility in Pick1 knockout mice. Our results indicate that the infertility is caused by the lack of PICK1 in the testis rather than in other organs. In addition, we found that seminiferous tubule microinjection of lentivirus has a strong preference to produce testis-specific transgenic mice

Different Approaches for Treating Multilevel Cervical Spondylotic Myelopathy: A Retrospective Study of 153 Cases from a Single Spinal Center.

The optimal surgical treatment for multilevel cervical spondylotic myelopathy (MCSM) remains controversial. This study compared the outcomes of three surgical approaches for MSCM treatment, focusing on the efficacy and safety of a combined approach.This retrospective study included 153 consecutive MCSM patients (100 men, 53 women; mean age ± standard deviation, 55.7 ± 9.4 years) undergoing operations involving ≥3 intervertebral segments. The patients were divided into three groups according to surgical approach: anterior (n = 19), posterior (n = 76), and combined (n = 58). We assessed demographic variables, perioperative parameters, and clinical outcomes ≥12 months after surgery (20.5 ± 7.6 months), including Japanese Orthopaedic Association (JOA) score, improvement, recovery rate, and complications.The anterior group had the most favorable preoperative conditions, including the highest preoperative JOA score (12.95 ± 1.86, p = 0.046). In contrast, the combined group had the highest occupancy ratio (48.0% ± 11.6%, p = 0.002). All groups showed significant neurological improvement at final follow-ups, with JOA recovery rates of 59.7%, 54.6%, and 68.9% in the anterior, posterior, and combined groups, respectively (p = 0.163). After multivariable adjustments, the groups did not have significantly different clinical outcomes (postoperative JOA score, p = 0.424; improvement, p = 0.424; recovery rate, p = 0.080). Further, subgroup analyses of patients with occupancy ratios ≥50% showed similar functional outcomes following the posterior and combined approaches. Overall complication rates did not differ significantly among the three approaches (p = 0.600). Occupancy ratios did not have a significant negative influence on postoperative recovery following the posterior approach.If applied appropriately, all three approaches are effective for treating MCSM. All three approaches had equivalent neurological outcomes, even in subgroups with high occupancy ratios. Further investigations of surgical approaches to MCSM are needed, particularly prospective multicenter studies with long-term follow-up

Operation-related parameters of patients classified by surgical approach.

<p>NA indicates not applicable. Results are presented as mean ± standard deviation or number (percentage).</p><p>* Segments refer to intervertebral segments; for instance, C3-7 is considered as 4 segments.</p><p>Operation-related parameters of patients classified by surgical approach.</p

A 53-year-old man who had multilevel cervical spondylotic myelopathy and underwent a combined surgical approach.

<p>He suffered from compressions at the C3-6 level (A–D) with a canal occupancy ratio of 54.9% at the maximal compression level (C4-5, compressed by both OPLL and the herniated disc), and was treated with C3-7 laminoplasty followed by C5 ACCF (E–H). Two years after surgery, his JOA score had improved from 8.0 to 16.0 without radiological recompression. (A) Preoperative neutral lateral radiograph. (B) Preoperative T2-weighted sagittal MRI. (C) Preoperative T2-weighted axial MRI at the C4-5 level. (D) Preoperative CT image at the C4-5 level. (E) Postoperative neutral lateral radiograph. (F) Postoperative T2-weighted sagittal MRI. (G) Postoperative T2-weighted axial MRI at the C4-5 level. (H) Postoperative CT image at the C4-5 level. Arrows indicate the maximal compression levels (B, F) where the axial MRI (C, G) and CT (D, H) images should be localized (Scale bar, 10 mm).</p

Postoperative neurological functions and complications.

<p>JOA indicates Japanese Orthopaedic Association; CSF, cerebrospinal fluid. The unadjusted results are presented as mean ± standard deviation or number (percentage), while the adjusted results (indicated by *) are presented as mean ± standard error.</p><p>* Adjusted for the demographic and preoperative parameters, including sex, age, body mass index, diabetes, hypertension, smoking, drinking, duration of symptoms, preoperative JOA score, increased signal intensity on T2-weighted MR imaging, canal occupancy ratio, anteroposterior diameter, Pavlov ratio, and Ishihara’s curvature index.</p><p>Postoperative neurological functions and complications.</p

Subgroup analyses of the MCSM patients with occupancy ratios ≥ 50%.

<p>JOA indicates Japanese Orthopaedic Association. Results are presented as mean ± standard deviation or number only.</p><p>* Because of the limited sample size (n = 3), the anterior approach was excluded from the statistical comparisons.</p><p>Subgroup analyses of the MCSM patients with occupancy ratios ≥ 50%.</p

Demographic and preoperative data of patients classified by surgical approach.

<p>JOA indicates Japanese Orthopaedic Association; ISI, increased signal intensity; T2WI, T2-weighted magnetic resonance imaging; AP, anteroposterior. Results are presented as mean ± standard deviation, number (percentage), or number only.</p><p>Demographic and preoperative data of patients classified by surgical approach.</p