Improved lithium ion battery performance by mesoporous Co3O 4 nanosheets grown on self-standing NiSix nanowires on nickel foam

Novel three-dimensional (3D) hierarchical NiSix/Co 3O4 core-shell nanowire arrays composed of NiSi x nanowire cores and branched Co3O4 nanosheet shells have been successfully synthesized by combining chemical vapor deposition and a simple but effective chemical bath deposition process followed by a calcination process. The resulting hierarchical NiSix/Co 3O4 core-shell nanowire arrays directly serve as binder- and conductive-agent-free electrodes for lithium ion batteries, which demonstrate remarkably improved electrochemical performances with excellent capacity retention and high rate capability on cycling. They can maintain a stable reversible capacity of 1279 mA h g-1 after 100 cycles at a current density of 400 mA g-1 and a capacity higher than 340 mA h g-1 even at a current density as high as 8 A g-1. Such superior electrochemical performance of the electrodes made by directly growing electro-active highly porous Co3O4 on a nanostructured NiSix conductive current collector makes them very promising for applications in high-performance lithium ion batteries. ? 2014 the Partner Organisations

Histone demethylase KDM5D drives sex-specific differences in colorectal cancer

View full abstracthttps://openworks.mdanderson.org/leading-edge/1011/thumbnail.jp

Genetic and Functional Dissection of HTRA1 and LOC387715 in Age-Related Macular Degeneration

A common haplotype on 10q26 influences the risk of age-related macular degeneration (AMD) and encompasses two genes, LOC387715 and HTRA1. Recent data have suggested that loss of LOC387715, mediated by an insertion/deletion (in/del) that destabilizes its message, is causally related with the disorder. Here we show that loss of LOC387715 is insufficient to explain AMD susceptibility, since a nonsense mutation (R38X) in this gene that leads to loss of its message resides in a protective haplotype. At the same time, the common disease haplotype tagged by the in/del and rs11200638 has an effect on the transcriptional upregulation of the adjacent gene, HTRA1. These data implicate increased HTRA1 expression in the pathogenesis of AMD and highlight the importance of exploring multiple functional consequences of alleles in haplotypes that confer susceptibility to complex traits

Y CHROMOSOME GENE KDM5D EPIGENETICALLY DRIVES SEX DIFFERENCES IN COLORECTAL CANCER

Sex exerts a profound impact on cancer incidence, spectrum and outcomes, yet the molecular genetic bases of such sex differences are ill-defined and presumptively ascribed to X-chromosome genes and sex hormones. Such sex differences are particularly prominent in colorectal cancer (CRC) where men experience higher metastases and mortality. A murine CRC model, engineered with an inducible transgene encoding oncogenic mutant KRASG12D and conditional null alleles of Apc and Trp53 tumor suppressors (designated iKAP), revealed higher metastases and worse outcomes specifically in males with oncogenic mutant KRAS (KRAS*) CRC. Integrated cross-species molecular and transcriptomic analyses identified Y-chromosome gene histone demethylase KDM5D as a transcriptionally up-regulated gene driven by KRAS*-mediated activation of the STAT4 transcription factor in cancer cells. KDM5D-dependent chromatin mark and transcriptome changes showed repression of regulators of the epithelial cell tight junction and MHC class I complex components. Deletion of Kdm5d in iKAP cancer cells increased tight junction integrity, decreased cell invasiveness, and enhanced cancer cell killing by CD8+ T cells. Conversely, iAP mice engineered with a Kdm5d transgene to provide constitutive Kdm5d expression specifically in iAP cancer cells exhibited an increased propensity for more invasive tumors in vivo. In addition, upregulated KDM5D expression in CD8+ T cells contributes to a suppressive immune response in men. Thus, upregulation of Y chromosome KDM5D in cancer cells and immune cells collaboratively contributes to the sex differences in CRC via its disruption of cancer cell adhesion properties and regulation of tumor immunity, providing an actionable therapeutic strategy for metastasis risk reduction for men afflicted with KRAS* CRC

Intermittent Deep Tillage on Improving Soil Physical Properties and Crop Performance in an Intensive Cropping System

Soil management practices are important parts of sustainable agriculture. Improving tillage practice is important for alleviating soil degradation and promoting sustainable grain production. A four year field experiment was conducted to examine the effects of deep tillage (DT), incorporated into the minimum tillage (MT), on soil physical properties and crop performance. The field experiments included continuous rotary tillage (RT), continuous DT, and intermittent DT every three years, every two years, and every other year, into RT. The results showed that the introduction of DT into continuous RT reduced the soil bulk density of the 20–30 cm soil layer by 5.6% and reduced nutrient stratification rates by 20–30%, which favored more uniformly distributed soil nutrients in the top soil layer. The root growth for treatments with DT in the deep soil layers (1–1.5 m) was significantly improved, which resulted in a higher soil water depletion. Under deficit irrigation scheduling, the improved root growth and soil water uptake in the deep soil layer improved crop growth and grain production. Overall, a 10.5% increase in yield and 18.3% increase in water productivity were observed when intermittent DT was introduced during the four years. The effects of DT could be maintained for two continuous years. Therefore, it was suggested that after two or three years of RT, DT should be applied to improve soil physical properties and ensure high grain production

Intermittent Deep Tillage on Improving Soil Physical Properties and Crop Performance in an Intensive Cropping System

Soil management practices are important parts of sustainable agriculture. Improving tillage practice is important for alleviating soil degradation and promoting sustainable grain production. A four year field experiment was conducted to examine the effects of deep tillage (DT), incorporated into the minimum tillage (MT), on soil physical properties and crop performance. The field experiments included continuous rotary tillage (RT), continuous DT, and intermittent DT every three years, every two years, and every other year, into RT. The results showed that the introduction of DT into continuous RT reduced the soil bulk density of the 20–30 cm soil layer by 5.6% and reduced nutrient stratification rates by 20–30%, which favored more uniformly distributed soil nutrients in the top soil layer. The root growth for treatments with DT in the deep soil layers (1–1.5 m) was significantly improved, which resulted in a higher soil water depletion. Under deficit irrigation scheduling, the improved root growth and soil water uptake in the deep soil layer improved crop growth and grain production. Overall, a 10.5% increase in yield and 18.3% increase in water productivity were observed when intermittent DT was introduced during the four years. The effects of DT could be maintained for two continuous years. Therefore, it was suggested that after two or three years of RT, DT should be applied to improve soil physical properties and ensure high grain production