Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA.

N6-methyladenosine (m6A) modification provides an important epitranscriptomic mechanism that critically regulates RNA metabolism and function. However, how m6A writers attain substrate specificities remains unclear. We report the 3.1 Å-resolution crystal structure of human CCHC zinc finger-containing protein ZCCHC4, a 28S rRNA-specific m6A methyltransferase, bound to S-adenosyl-L-homocysteine. The methyltransferase (MTase) domain of ZCCHC4 is packed against N-terminal GRF-type and C2H2 zinc finger domains and a C-terminal CCHC domain, creating an integrated RNA-binding surface. Strikingly, the MTase domain adopts an autoinhibitory conformation, with a self-occluded catalytic site and a fully-closed cofactor pocket. Mutational and enzymatic analyses further substantiate the molecular basis for ZCCHC4-RNA recognition and a role of the stem-loop structure within substrate in governing the substrate specificity. Overall, this study unveils unique structural and enzymatic characteristics of ZCCHC4, distinctive from what was seen with the METTL family of m6A writers, providing the mechanistic basis for ZCCHC4 modulation of m6A RNA methylation

Review of National Conference on the Theoretical Study of Science Popularization: Theoretical and Practical Studies of Science Popularization

Ever since modern science was introduced into China, Chinese progressive intellectuals began to actively communicate science, hoping to raise and improve the vision and quality of Chinese society. With the constant development of China’s popular science career and innovating popular science practices, the demand for theoretical research in science popularization is constantly increasing. Meanwhile, the abundant practice and study has formed a certain paradox with the research on science communication lagging behind. Thus, the need of the hour is to have a strong base for theoretical research (Chuanhong, 2010)

An innovative concentrated solar power system driven by high-temperature cascade organic Rankine cycle

Direct steam generation (DSG) solar power systems eliminate synthetic oils and molten salts in the solar field and enable efficient heat collection. Commercial DSG solar plants usually have a steam generation temperature of 250–285 °C to reduce the technical challenges of wet steam turbines and the costs of high-pressure water storage tanks. The power conversion efficiency is relatively low due to the limited steam generation temperature. This paper proposes a high-temperature solar power system driven by the cascade organic Rankine cycle (CORC). It has three features: water/steam for solar heat transfer, water and phase change material (PCM) for heat storage, and CORC for power conversion. It is the first time that the storage tank temperature is independent of the steam generation temperature in a DSG. Steam can be generated in the solar field at a temperature of 310 °C or even 370 °C. The fundamental of the innovative system is illustrated. The thermodynamic performances during the normal operation and discharge processes are investigated. The results show the maximum thermal efficiency of the CORC system in the normal operation mode is 32.85% at a steam temperature of 311 °C, while the top and bottom cycle efficiencies are 15.38% and 20.86%, respectively. The efficiency increases to more than 37% at 370 °C. Combining the two-tank storage and the PCM unit can overcome the problems of decreasing the heat release rate from PCM during heat discharge while maintaining the CORC system's power output and prolonging the heat storage time. The proposed system is potentially more cost-effective than the existing DSG solar plants

Ceria–terbia solid solution nanobelts with high catalytic activities for CO oxidation

Ceria–terbia solid solution nanobelts were prepared by an electrochemical route and tested as catalysts of high activity for CO oxidation