SLC25A1-associated prognostic signature predicts poor survival in acute myeloid leukemia patients

Background: Acute myeloid leukemia (AML) is a heterogeneous malignant disease. SLC25A1, the gene encoding mitochondrial carrier subfamily of solute carrier proteins, was reported to be overexpressed in certain solid tumors. However, its expression and value as prognostic marker has not been assessed in AML.Methods: We retrieved RNA profile and corresponding clinical data of AML patients from the Beat AML, TCGA, and TARGET databases (TARGET_AML). Patients in the TCGA cohort were well-grouped into two group based on SLC25A1 and differentially expressed genes were determined between the SLC25A1 high and low group. The expression of SLC25A1 was validated with clinical samples. The survival and apoptosis of two AML cell lines were analyzed with SLC25A1 inhibitor (CTPI-2) treatment. Cox and the least absolute shrinkage and selection operator (LASSO) regression analyses were applied to Beat AML database to identify SLC25A1-associated genes for the construction of a prognostic risk-scoring model. Survival analysis was performed by Kaplan-Meier and receiver operator characteristic curves.Results: Our analysis revealed that high expressed level of SLC25A1 in AML patients correlates with unfavorable prognosis. Moreover, SLC25A1 expression was positively associated with metabolism activity. We further demonstrated that the inhibition of SLC25A1 could inhibit the proliferation and increase the apoptosis of AML cells. In addition, a panel of SLC25A1-associated genes, was identified to construct a prognostic risk-scoring model. This SLC25A1-associated prognostic signature (SPS) is an independent risk factor with high area under curve (AUC) values of receiver operating characteristic (ROC) curves. A high SPS in leukemia patients is associated with poor survival. A Prognostic nomogram including the SPS and other clinical parameters, was constructed and its predictive efficiency was confirmed.Conclusion: We have successfully established a SPS prognostic model that predict outcome and risk stratification in AML. This risk model can be used as an independent biomarker to assess prognosis of AML

Preparation of Edible Film Containing Sesame Oleosomes and Its Application in Strawberry Preservation

This study investigated the effects of adding different amounts of sesame oleosomes on the properties of polysaccharide edible films, and explored the application of the film incorporated with sesame oleosomes in strawberry preservation in terms of sensory evaluation and physicochemical indexes. The results showed that the extracted sesame oleosomes contained 72.3% fat, which could maintain good oxidative stability for 8 days. Adding an appropriate amount of sesame oleosomes to edible films could effectively improve the softness, water vapor barrier, solubility and elongation. However, adding excess sesame oleosomes (≥ 5.6%) decreased the mechanical properties and transparency. Taken together, the optimal proportion of oleosome addition was 1.2%. Compared with the blank and oleosome-free control groups, the oleosome-incorporated film effectively delayed the rotting and softening of strawberry fruits as well as the decrease in moisture, soluble solids and titratable acids, and extended the shelf life by at least 1 day. This study showed that a certain amount of oleosomes can be used as lipid derivatives in lipid-based edible films to extend the shelf life of fruits and vegetables

High Harmonic Generation Driven by Counter-Rotating Bicircular Laser Fields from Polar Chemical Bonds in <i>h</i>-BN

High harmonic generation (HHG) driven by counter-rotating bicircular (CRB) pulses excitation has been observed from several solid targets, where circularly polarized harmonics are emitted. We study this process using time-dependent density functional theory (TDDFT) to calculate the crystal orientation dependence of the circularly polarized high harmonics from a monolayer h-BN. The resulted can be interpreted by the real space electron dynamics of electrons in polar chemical bonds. The yield of circularly polarized high harmonics (CHHs) can be optimized by controlling the direction of valence electron dynamics. Our findings pave the way for exploring the binding potential from spectrum and all-optically processing information

Mean Square Exponential Stability of Stochastic Delay Differential Systems with Logic Impulses

This paper focuses on the mean square exponential stability of stochastic delay differential systems with logic impulses. Firstly, a class of nonlinear stochastic delay differential systems with logic impulses is constructed. Then, the logic impulses are transformed into an equivalent algebraic expression by using the semi-tensor product method. Thirdly, the mean square exponential stability criteria of nonlinear stochastic delay differential systems with logic impulses are given. Finally, two kinds of stochastic delay differential systems with logic impulses and uncertain parameters are discussed, and the coefficient conditions guaranteeing the mean square exponential stability of these systems are obtained

Future Time Perspective Impacts Gain-Related but Not Loss-Related Intertemporal Choice

Future time perspective (FTP) modulates individuals’ temporal orientation in selecting their motivations and goals, which widely influences their cognitions and behaviors. However, it remains unclear how FTP exactly affects intertemporal choice. To clarify the effect of FTP on intertemporal choice, 90 college students (Mage = 21.70, SD = 1.23) were randomly assigned to the limited FTP condition (16 males, 29 females) and the open-ended FTP condition (17 males, 28 females). In the limited FTP condition, participants were instructed to imagine their states of being 70 years old, whereas in the open-ended FTP condition, they were instructed to describe their current states. All participants then completed a series of intertemporal choice tasks, in which they chose from gain- and loss-related choices occurring at various time points. Results showed that the participants who received the future-imagining manipulation had more limited FTP compared with those who did not receive the manipulation, which confirmed the validity of the FTP manipulation. A 2 (FTP: limited vs. open-ended) × 2 (type of choice: gain vs. loss) repeated measures ANOVA on discount rate revealed a significant interaction between these two factors. The participants in the limited FTP condition had higher discount rates on gain-related choices but showed no difference on loss-related choices compared with the participants under the open-ended FTP condition. The results suggest that limited FTP could lower individuals’ future orientation (i.e., willingness to delay an outcome) on gain-related, but not on loss-related, intertemporal decision-making

Preliminary Study on the Removal of Steroidal Estrogens Using TiO2-Doped PVDF Ultrafiltration Membranes

Steroidal estrogens are a representative type of endocrine-disrupting chemical contaminant that has been detected in surface water. In this paper, modified polyvinylidene fluoride (PVDF) membranes were prepared by adding different amounts of polyvinyl pyrrolidone (PVP) and nano-TiO2 particles. PVDF-PVP membrane adsorption, UV photolysis and PVDF-PVP-TiO2 membrane photocatalysis performance were investigated by considering the rejection of estrone (E1) and 17β-estradiol (E2) in the cross-flow filtration experiments. The mechanism of photocatalytic degradation on TiO2-doped PVDF membranes was also evaluated. The results from the study indicated that adding PVP and nano-TiO2 appropriately in PVDF membranes could be an effective method for better E1and E2 rejection due to adsorption and photocatalytic degradation

LMI-Based Method of Robust Fault Detection H 4 Filter for Anti-Pinch of Pure Electric Vehicles

Abstract: In order to effectively solve the risk of safety on power window, this study introduces the LMI-based method of designing robust fault detection H 4 filter for anti-pinch window control system. For detecting the pinched condition, the pinch torque is considered as a fault to design a residual generator. By comparing the residual signal with the pre-designed threshold, the occurrence of pinch can be detected. The main contribution consisted of the formulation of the multi-objective optimization H 4 and H -problem as H 4 optimization problem by using the residual error instead of residual. The solution of the optimization problem is solved via LMI technique. Based on MATLAB, the results show that the algorithm can detect the fault after it occurs 70 ms. In addition, simulation results show that the proposed algorithm has high sensitivity to fault and strong robustness to uncertainties

Future Time Perspective Impacts Gain-Related but Not Loss-Related Intertemporal Choice

Future time perspective (FTP) modulates individuals’ temporal orientation in selecting their motivations and goals, which widely influences their cognitions and behaviors. However, it remains unclear how FTP exactly affects intertemporal choice. To clarify the effect of FTP on intertemporal choice, 90 college students (Mage = 21.70, SD = 1.23) were randomly assigned to the limited FTP condition (16 males, 29 females) and the open-ended FTP condition (17 males, 28 females). In the limited FTP condition, participants were instructed to imagine their states of being 70 years old, whereas in the open-ended FTP condition, they were instructed to describe their current states. All participants then completed a series of intertemporal choice tasks, in which they chose from gain- and loss-related choices occurring at various time points. Results showed that the participants who received the future-imagining manipulation had more limited FTP compared with those who did not receive the manipulation, which confirmed the validity of the FTP manipulation. A 2 (FTP: limited vs. open-ended) × 2 (type of choice: gain vs. loss) repeated measures ANOVA on discount rate revealed a significant interaction between these two factors. The participants in the limited FTP condition had higher discount rates on gain-related choices but showed no difference on loss-related choices compared with the participants under the open-ended FTP condition. The results suggest that limited FTP could lower individuals’ future orientation (i.e., willingness to delay an outcome) on gain-related, but not on loss-related, intertemporal decision-making