Research on Teaching Reform of "Engineering Fluid Mechanics" Based on Curriculum Ideology and Politics

This study aims to explore the teaching reform of Engineering Fluid Mechanics based on the concept of curriculum ideology and politics, in order to meet the needs of contemporary engineering education. The section on curriculum ideology and politics and Engineering Fluid Mechanics discusses the connotation, importance, teaching challenges, and the interrelation between curriculum ideology and politics and Engineering Fluid Mechanics. The teaching reform strategies section proposes directions for reform, including restructuring course objectives, adjusting teaching materials and teaching aids, innovating teaching methods, and improving assessment methods. The case analysis and practical experience section presents a summary of specific case analyses and practical experiences to inspire other educators. Finally, the teaching effectiveness evaluation section focuses on students' learning outcomes, feedback, and teachers' teaching experiences to verify the actual effects of the teaching reform

With Brexit, inward investment will fall in the UK

Supply chains cross borders many times before components go into a final product in any EU country, write David Bailey, Nigel Driffield and Michail Karoglo

Mechanism of circular RNA hsa_circ_0012779 expression in nasopharyngeal carcinoma and its influence on cell biological behavior

Background and purpose: Circular RNA (circRNA) plays an important regulatory role in the development of a variety of tumors. However, the abnormal expression and biological function of circRNA in nasopharyngeal carcinoma remain unclear. This study aimed to explore the effect of hsa_circ_0012779 on the biological behavior of nasopharyngeal carcinoma cells and its molecular mechanism. Methods: The expression of hsa_circ_0012779 in human immortalized nasopharyngeal epithelial cell line NP69 and nasopharyngeal carcinoma cell lines CNE2, 5-8F, HNE1 and SUNE1 was detected by real-time fluorescence quantitative polymerase chain reaction (RTFQ-PCR). Cell counting kit-8 (CCK-8) assay and transwell invasion assay were used to detect the effect of hsa_circ_0012779 on the proliferation and invasion ability of nasopharyngeal carcinoma cells. The protein level of ELAV like protein 1 (ELAVL1) in NPC cells with hsa_circ_0012779 knockdown was detected by Western blot. The binding of hsa_circ_0012779 and ELAVL1 was verified by RNA pull-down assay. Results: hsa_circ_0012779 was highly expressed in nasopharyngeal carcinoma tissues and cells. Knockdown hsa_circ_0012779 could inhibit the proliferation and invasion of nasopharyngeal carcinoma cells. hsa_circ_0012779 bound to RNA-binding protein ELAVL1 to promote its expression and colocalization in cytoplasm. In the meanwhile, the effect of knockdown hsa_circ_0012779 on nasopharyngeal carcinoma cells could be reversed by the overexpression of ELAVL1. Conclusion: hsa_circ_0012779 promote the expression of ELAVL1 and thus promote the proliferation and invasion of nasopharyngeal carcinoma, and influence the occurrence and development of nasopharyngeal carcinoma

Locate and Beamform: Two-dimensional Locating All-neural Beamformer for Multi-channel Speech Separation

Recently, stunning improvements on multi-channel speech separation have been achieved by neural beamformers when direction information is available. However, most of them neglect to utilize speaker's 2-dimensional (2D) location cues contained in mixture signal, which limits the performance when two sources come from close directions. In this paper, we propose an end-to-end beamforming network for 2D location guided speech separation merely given mixture signal. It first estimates discriminable direction and 2D location cues, which imply directions the sources come from in multi views of microphones and their 2D coordinates. These cues are then integrated into location-aware neural beamformer, thus allowing accurate reconstruction of two sources' speech signals. Experiments show that our proposed model not only achieves a comprehensive decent improvement compared to baseline systems, but avoids inferior performance on spatial overlapping cases.Comment: Accepted by Interspeech 2023. arXiv admin note: substantial text overlap with arXiv:2212.0340

Infection with blast fungus ( Magnaporthe orzyae) leads to increased expression of an arabinogalactan-protein epitope in both susceptible and resistant rice cultivars

Blast fungus (Magnaporthe orzyae) is the most serious pathogen of rice. As such, the objective of the current study was to investigate the infection process using a selected panel of anti-plant extracellular matrix antibodies, in infected leaves from three rice cultivars that display varying degrees of resistance to the pathogen; at selected time points post inoculation. An arabinogalactan-protein (AGP) epitope, recognized by the antibody JIM13, was shown to be temporally and spatially regulated during the infection, in all three cultivars. Prior to inoculation, expression of the epitope was confined to the epidermis, sclerenchyma, phloem, xylem and bundle sheath. As the infection progressed, the intensity of labeling increased in all the aforementioned cell types and spread to the mesophyll. Immunogold transmission electron microscopy, revealed this epitope to be most abundant at the plasma membrane. These data suggest that this epitope is borne on a plasma-membrane-associated AGP, which may act as a pattern recognition receptor (PRR), involved in the basal immune response to infection with blast fungus, in both resistant and susceptible rice cultivars. As such, this study represents the first report of a membrane – associated arabinogalactan-protein in rice, which once cloned, could be of utility in future breeding programs/genetic modification to improve the basal immune response to blast fungus and other pathogens, in this globally important food crop