Simultaneous muscle force and displacement transducer

A myocardial transducer for simultaneously measuring force and displacement within a very small area of myocardium is disclosed. The transducer comprised of an elongated body forked at one end to form an inverted Y shaped beam with each branch of the beam constituting a low compliant tine for penetrating the myocardium to a predetermined depth. Bonded to one of the low compliance tines is a small piezoresistive element for converting a force acting on the beam into an electrical signal. A third high compliant tine of the transducer, which measures displacement of the myocardium in a direction in line with the two low compliant tines, is of a length that just pierces the surface membrane. A small piezoresistive element is bonded to the third tine at its upper end where its bending is greatest. Displacement of the myocardium causes a deformation in curvature of the third tine, and the second small piezoresistive element bonded to the surface of its curved end converts its deformation into an electrical signal

Multifunctional transducer

Several parameters of a small region of a muscle tissue or other object, can be simultaneously measured using with minimal traumatizing or damage of the object, a trifunctional transducer which can determine the force applied by a muscle fiber, the displacement of the fiber, and the change in thickness of the fiber. The transducer has three legs with inner ends joined together and outer ends formed to piece the tissue and remain within it. Two of the legs are relatively stiff, to measure force applied by the tissue, and a third leg is relatively flexible to measure displacement of the tissue relative to one or both stiff legs, and with the three legs lying in a common plane so that the force and displacement measurements all relate to the same direction of muscle movements. A flexible loop is attached to one of the stiff legs to measure changes in muscle thickness, with the upper end of the loop fixed to the leg and the lower end of the loop bearing against the surface of the tissue and being free to slide on the leg

Modeling the evolution of infrared luminous galaxies: the influence of the Luminosity-Temperature distribution

The evolution of the luminous infrared galaxy population is explored using a pure luminosity evolution model which incorporates the locally observed luminosity-temperature distribution for IRAS galaxies. Pure luminosity evolution models in a fixed $\Lambda$CDM cosmology are fitted to submillimeter (submm) and infrared counts, and backgrounds. It is found that the differences between the locally determined bivariate model and the single variable luminosity function (LF) do not manifest themselves in the observed counts, but rather are primarily apparent in the dust temperatures of sources in flux limited surveys. Statistically significant differences in the redshift distributions are also observed. The bivariate model is used to predict the counts, redshifts and temperature distributions of galaxies detectable by {\it Spitzer}. The best fitting model is compared to the high-redshift submm galaxy population, revealing a median redshift for the total submm population of $z=1.8^{+0.9}_{-0.4}$, in good agreement with recent spectroscopic studies of submillimeter galaxies. The temperature distribution for the submm galaxies is modeled to predict the radio/submm indices of the submm galaxies, revealing that submm galaxies exhibit a broader spread in spectral energy distributions than seen in the local IRAS galaxies.Comment: Accepted for publication in ApJ. Quality of several figures reduced due to size restriction

Myocardium wall thickness transducer and measuring method

A miniature transducer for measuring changes of thickness of the myocardium is described. The device is easily implantable without traumatizing the subject, without affecting the normal muscle behavior, and is removable and implantable at a different muscle location. Operating features of the device are described

Catheter tip force transducer for cardiovascular research

A force transducer for measuring dynamic force activity within the heart of a subject essentially consists of a U-shaped beam of low elastic compliance material. Two lines extend from the beams's legs and a long coil spring is attached to the beam. A strain gauge is coupled to one of the beam's legs to sense deflections thereof. The beam with the tines and most of the spring are surrounded by a flexible tube, defining a catheter, which is insertable into a subject's heart through an appropriate artery. The tines are extractable from the catheter for implantation into the myocardium by pushing on the end of the spring which extends beyond the external end of the catheter

High-efficiency AlGaAs-GaAs Cassegrainian concentrator cells

AlGaAs-GaAs heteroface space concentrator solar cells have been fabricated by metalorganic chemical vapor deposition. AMO efficiencies as high as 21.1% have been observed both for p-n and np structures under concentration (90 to 100X) at 25 C. Both cell structures are characterized by high quantum efficiencies and their performances are close to those predicted by a realistic computer model. In agreement with the computer model, the n-p cell exhibits a higher short-circuit current density

Robustness of the Thirty Meter Telescope Primary Mirror Control System

The primary mirror control system for the Thirty Meter Telescope (TMT) maintains the alignment of the 492 segments in the presence of both quasi-static (gravity and thermal) and dynamic disturbances due to unsteady wind loads. The latter results in a desired control bandwidth of 1Hz at high spatial frequencies. The achievable bandwidth is limited by robustness to (i) uncertain telescope structural dynamics (control-structure interaction) and (ii) small perturbations in the ill-conditioned influence matrix that relates segment edge sensor response to actuator commands. Both of these effects are considered herein using models of TMT. The former is explored through multivariable sensitivity analysis on a reduced-order Zernike-basis representation of the structural dynamics. The interaction matrix ("A-matrix") uncertainty has been analyzed theoretically elsewhere, and is examined here for realistic amplitude perturbations due to segment and sensor installation errors, and gravity and thermal induced segment motion. The primary influence of A-matrix uncertainty is on the control of "focusmode"; this is the least observable mode, measurable only through the edge-sensor (gap-dependent) sensitivity to the dihedral angle between segments. Accurately estimating focus-mode will require updating the A-matrix as a function of the measured gap. A-matrix uncertainty also results in a higher gain-margin requirement for focus-mode, and hence the A-matrix and CSI robustness need to be understood simultaneously. Based on the robustness analysis, the desired 1 Hz bandwidth is achievable in the presence of uncertainty for all except the lowest spatial-frequency response patterns of the primary mirror

Quasar Microlensing at High Magnification and the Role of Dark Matter: Enhanced Fluctuations and Suppressed Saddlepoints

Contrary to naive expectation, diluting the stellar component of the lensing galaxy in a highly magnified system with smoothly distributed ``dark'' matter increases rather than decreases the microlensing fluctuations caused by the remaining stars. For a bright pair of images straddling a critical curve, the saddlepoint (of the arrival time surface) is much more strongly affected than the associated minimum. With a mass ratio of smooth matter to microlensing matter of 4:1, a saddlepoint with a macro-magnification of mu = 9.5 will spend half of its time more than a magnitude fainter than predicted. The anomalous flux ratio observed for the close pair of images in MG0414+0534 is a factor of five more likely than computed by Witt, Mao and Schechter if the smooth matter fraction is as high as 93%. The magnification probability histograms for macro-images exhibit distinctly different structure that varies with the smooth matter content, providing a handle on the smooth matter fraction. Enhanced fluctuations can manifest themselves either in the temporal variations of a lightcurve or as flux ratio anomalies in a single epoch snapshot of a multiply imaged system. While the millilensing simulations of Metcalf and Madau also give larger anomalies for saddlepoints than for minima, the effect appears to be less dramatic for extended subhalos than for point masses. Morever, microlensing is distinguishable from millilensing because it will produce noticeable changes in the magnification on a time scale of a decade or less.Comment: As accepted for publication in ApJ. 17 pages. Substantial revisions include a discussion of constant M/L models and the calculation of a "photometric" dark matter fraction for MG0414+053

Monetary costs of agitation in older adults with Alzheimer's disease in the UK: prospective cohort study

While nearly half of all people with Alzheimer's disease (AD) have agitation symptoms every month, little is known about the costs of agitation in AD. We calculated the monetary costs associated with agitation in older adults with AD in the UK from a National Health Service and personal social services perspective