83 research outputs found
Prognostic risk stratification with SPECT imaging: results from a 20,340 patient multicenter registry
High-gain nonlinear observer for simple genetic regulation process
High-gain nonlinear observers occur in the nonlinear automatic control theory
and are in standard usage in chemical engineering processes. We apply such a
type of analysis in the context of a very simple one-gene regulation circuit.
In general, an observer combines an analytical differential-equation-based
model with partial measurement of the system in order to estimate the
non-measured state variables. We use one of the simplest observers, that of
Gauthier et al., which is a copy of the original system plus a correction term
which is easy to calculate. For the illustration of this procedure, we employ a
biological model, recently adapted from Goodwin's old book by De Jong, in which
one plays with the dynamics of the concentrations of the messenger RNA coding
for a given protein, the protein itself, and a single metabolite. Using the
observer instead of the metabolite, it is possible to rebuild the non-measured
concentrations of the mRNA and the proteinComment: 9 pages, one figur
Blooms of surf-zone diatoms along the coast of the Olympic Peninsula, Washington. X. Chemical composition of the surf diatom Chaetoceros armatum and its major herbivore, the Pacific razor clam Siliqua patula
Prognostic value of a normal myocardial perfusion SPECT in patients undergoing coronary angiography
Paneth cell-rich papillary adenocarcinoma and a mucoid adenocarcinoma occurring synchronously in colon: a light and electron microscopic study
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