1,812 research outputs found

    The Economic Effects of Spectrum Trading

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    We consider a model in which Cournot-Nash oligopolistic service providers are able to trade radio spectrum licences, subject to interference constraints. The terms of trade are endogenised through Nash bargaining. When the providers are in the same (geographical) market, the incentive to trade is due to cost differences; when they are in separate markets, differential demand conditions can also stimulate trade. We show that trade can enhance the productive efficiency of service provision (by concentrating production in low cost firms) but the resulting service consumer prices may have negative welfare implications. We then present numerical results from a program designed to simulate trading scenarios. these results illustrate a number of outcomes of allowing licence trades. We discuss a number of applications and extensions for our model and the relevance of our results for current government consultations on spectrum trading.

    Firearms, Youth Homicide, and Public Health

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    Homicide is seven times as common among U.S. non-Hispanic Black as among non-Hispanic White youth ages 15 to 24 years. In 83% of these youth homicides, the murder weapon is a firearm. Yet, for more than a decade, the national public health position on youth violence has been largely silent about the role of firearms, and tools used by public health professionals to reduce harm from other potential hazards have been unusable where guns are concerned. This deprives already underserved populations from the full benefits public health agencies might be able to deliver. In part, political prohibitions against research about direct measures of firearm control and the absence of valid public health surveillance are responsible. More refined epidemiologic theories as well as traditional public health methods are needed if the U.S. aims to reduce disparate Black-White youth homicide rates

    Introduction of Foreign Genes into the Tissue of Live Fish by Direct Injection and Particle Bombardment

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    We compared 2 methods of direct gene delivery into live rainbow trout Oncorhynchus mykiss tissue, with the final goal of developing DNA-based vaccines for bacterial diseases in salmonids. The introduction of plasmid constructs containing the luciferase and β-galactosidase reporter genes was achieved either by direct injection or by particle bombardment with DNA-coated gold microparticles. Luciferase expression was observed in homogenates of trout flank muscle and skin 2 d after injection of 10 to 100 pg of DNA per fish or bombardment of 1 pm gold particles coated with 5 to 25 pg DNA per fish at helium pressures ranging from 2750 to 12 400 kPa. Expression levels increased over 10 d and persisted for at least 60 d after injection. For particle bombardment, the most reproducible levels of luciferase expression were obtained with the eye as a target (83% of fish positive versus 59% of fish positive when the flank was the target). The levels of luciferase expression observed after particle bombardment were significantly lower (t-test, p \u3c 0.02) than the levels measured after direct injection. Immunohistochemical analysis indicated β-galactosidase gene expression in muscle cells at the site of injection and in the dermis, epidermis and muscle after bombardment. These 2 methods may prove valuable for the development of a new generation of DNA-based vaccines for fish

    HIV associated dementia and HIV encephalitis II: Genes on chromosome 22 expressed in individually microdissected Globus pallidus neurons (Preliminary analysis)

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    We analyzed RNA gene expression in neurons from 16 cases in four categories, HIV associated dementia with HIV encephalitis (HAD/HIVE), HAD alone, HIVE alone, and HIV-1-positive (HIV+)with neither HAD nor HIVE. We produced the neurons by laser capture microdissection (LCM) from cryopreserved globus pallidus. Of 55,000 gene fragments analyzed, expression of 197 genes was identified with significance (p = 0.005).We examined each gene for its position in the human genome and found a non-stochastic occurrence for only seven genes, on chromosome 22. Six of the seven genes were identified, CSNK1E (casein kinase 1 epsilon), DGCR8 (Di George syndrome critical region 8), GGA1 (Golgi associated gamma adaptin ear containing ARF binding protein 1), MAPK11 (mitogen activated protein kinase 11), SMCR7L (Smith-Magenis syndrome chromosome region candidate 7-like), andTBC1D22A (TBC1 domain family member 22A). Six genes (CSNK1E, DGCR8, GGA1, MAPK11, SMCR7L, and one unidentified gene) had similar expression profiles across HAD/HIVE, HAD, and HIVE vs. HIV+ whereas one gene (TBC1D22A) had a differing gene expression profile across these patient categories. There are several mental disease-related genes including miRNAs on chromosome 22 and two of the genes (DGCR8 and SMCR7L) identified here are mental disease-related. We speculate that dysregulation of gene expression may occur through mechanisms involving chromatin damage and remodeling. We conclude that the pathogenesis of NeuroAIDS involves dysregulation of expression of mental disease-related genes on chromosome 22 as well as additional genes on other chromosomes. The involvement of these genes as well as miRNA requires additional investigation since numerous genes appear to be involved

    Moyo Vol. IX N 2

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    Million, Chris. Dirge For a Restroom, the Search For a Progressive Potty Rages on . 4. Fisher, Dan. The White Crow: Compassionate Activism in a Tibetan Community-in-Exile . 5. Barrett, Laura. Indie Films for Indie Spirit (Cinema is the Most Important Art) . 6. Levine, Robert. American interview. Making a Film About Making a Film: A Cozy Chat With Two Independent Filmmakers . 8. Hiller, Andy. Cameras and Cappuccinos . 9. Shuba, Jason J. Technology on Trial: Appreciating Modernity (Technology as Human Progress) . 12. Dunson, Jim. Technology on Trial: The Role of Choice (Can Progress be The Only Option?) . 13. Levine, Robert. Cash, Blood, and Coffee (Life as an NYC Film Intern) . 14. Durica, Paul. The Lost Crusade: Former Editor Muses on the Myth of True Love . 22. Hankinson, Tom. The Real Appeal of Cinema . 23

    Moyo Vol. VII N 1

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    Durica, Paul. Editor\u27s Letter . 4 Lemke, Angelica. Paxil, Effexor, and Prozac, Oh My! Is Depression Awareness Day Going Too Far? 5. Frey, Randall. Just Be: How to Make Money Without Really Doing Anything . 6. Purks, Robert. 007, Missing The Action. Dalton\u27s Bond Reconsidered . 7. Stine, Alison. Hatching A masterpiece: Jeffery Hatcher Talks of Writing, Melville, Woody Allen, and Denison . 8. Levine, Robert. Dial DU For Murder: Cinema Student Shuffles Off The Mortal Coil, and Finds it an Acquired Taste . 13. Almirall, Sarah. Dial DU For Murder: Cinema Student Shuffles Off The Mortal Coil, and Finds it an Acquired Taste, Photographs . 13. Werne, Kirsten. Back in the Day (Mom and Pop Alums Reflect on the Sixties Social Scene) . 18. Kohlbecker, Matthew. Between a Rock and a Hard Place (A Geological Excursion Into the Wilds of Canada) . 20. Lammont, Jean. Where\u27s Waldon? Comments on the Homestead . 21. Frey, Randall. Me Experimenting with Berry Beer . 25. Frey, Randall. Shoes for Mr. Jordan . 28. Porcheddu, Fred. My Late Adolescence . 30. Combe, Clayton. The Modern Guinea Pig . 31

    Moyo Vol. VII N 2

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    Durica, Paul. Editor\u27s Letter . 4. Spears, Amy L. As If Lipstick Was A Sign of My Declining Mind (How ChickRock Happened) . 5. Frey, Randall. Portrait of the Cartoonist as a Young Man . 6. Clements, Nina. Grease Me Up: One Woman\u27s Descent into the Depths of Pittsburgh Dinner Culture . 7. Levine, Robert. Under the Needle\u27s Point (The Healing Power of Acupuncture) . 8. Durica, Paul. The Glory that was/is Greek: Denison Three Years After the Decision . 12. Lamont, Jean. Smokin\u27 Joe Lights Up . 13. Durica, Paul. Ode on a Second Grecian Turn: An Interview with President Michele T. Myers . 14. Fisher, Dan. Lenane on the Social Scene . 19. Combe, Kirk. Intellectual Bio-Diversity: A Faculty Perspective on the Greek Residential Issue . 20. Williams, Adam. Elephants on the Floor Above and Brats in the Basement: Life on the North Quad . 22. Pfleeger, Jon. New Kid on the Block (Sigma Phi Epsilon\u27s President Speaks) . 23. Werne, Kirsten. Coffee Talk at the Bandersnatch (An Interview with Kevin Clay and Adam) . 29

    2003 Manifesto on the California Electricity Crisis

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    The authors, an ad-hocgroup of professionals with experience in regulatory and energy economics, share a common concern with the continuing turmoil facing the electricity industry ("the industry") in California. Most ofthe authorsendorsed the first California Electricity Manifesto issued on January 25, 2001. Almost two years have passed since that first Manifesto. While wholesale electric prices have moderated and California no longer faces the risk of blackouts, in many ways the industry is in worse shape now than it was at the start of 2001. As a result, the group of signatories continues to have a deep concern with the conflicting policy directions being pursued for the industry at both the State and Federal levels of government and the impact the uncertainties associated with these conflicting policies will have, long term, on the economy of California. Theauthorshave once again convened under the auspices of the Institute of Management, Innovation and Organization at the University of California, Berkeley, to put forward ourtheir ideas on a basic set of necessary policies to move the industry forward for the benefit of all Californians and the nation. The authors point out that theydo not pretend to be "representative." They do bring, however, a very diverse range of backgrounds and expertise.Technology and Industry, Regulatory Reform

    'Tough'-constructions and their derivation

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    This article addresses the syntax of the notorious 'tough' (-movement) construction (TC) in English. TCs exhibit a range of apparently contradictory empirical properties suggesting that their derivation involves the application of both A-movement and A'-movement operations. Given that within previous Principles and Parameters models TCs have remained “unexplained and in principle unexplainable” (Holmberg 2000: 839) due to incompatibility with constraints on theta-assignment, locality, and Case, this article argues that the phase-based implementation of the Minimalist program (Chomsky 2000, 2001, 2004) permits a reanalysis of null wh-operators capable of circumventing the previous theoretical difficulties. Essentially, 'tough'-movement consists of A-moving a constituent out of a “complex” null operator which has already undergone A'-movement, a “smuggling” construction in the terms of Collins (2005a,b
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