Use of BIM scenarios by operations services to work with the building information model

Information systems with ever-growing and increasingly complex functionality are being actively introduced into the operation services. In the process of development, the information technology finds new ways to improve efficiency of economic activities for enterprises. However, the use of automated operation control systems in the absence of representation of the construction object as a single system leads to an increase in labor costs and resource losses. There are inefficiently used operation facilities of the maintenance services that have to be solved, including energy efficiency. Many experts of operation do not have enough skills to interact with information model. There is a need to expand the application of BIM beyond construction and design, to learn to use the information obtained at these stages. Automated data collection of BIM can solve such problems with the help of BIM scenario or BIM-use. Each set of works with information about the stage of the life cycle of the project and part of project in international practice is called BIM scenarios. In general, the use of BIM scenarios and information modeling (IM) shows a composite, yet little-researched activity that can provide the necessary effect in maintenance, operation, document management, checking the energy efficiency of the building

Histone H3.3 lysine 9 and 27 control repressive chromatin at cryptic enhancers and bivalent promoters

Histone modifications are associated with distinct transcriptional states, but it is unclear whether they instruct gene expression. To investigate this, we mutate histone H3.3 K9 and K27 residues in mouse embryonic stem cells (mESCs). Here, we find that H3.3K9 is essential for controlling specific distal intergenic regions and for proper H3K27me3 deposition at promoters. The H3.3K9A mutation resulted in decreased H3K9me3 at regions encompassing endogenous retroviruses and induced a gain of H3K27ac and nascent transcription. These changes in the chromatin environment unleash cryptic enhancers, resulting in the activation of distinctive transcriptional programs and culminating in protein expression normally restricted to specialized immune cell types. The H3.3K27A mutant disrupts the deposition and spreading of the repressive H3K27me3 mark, particularly impacting bivalent genes with higher basal levels of H3.3 at promoters. Therefore, H3.3K9 and K27 crucially orchestrate repressive chromatin states at cis-regulatory elements and bivalent promoters, respectively, and instruct proper transcription in mESCs

A systematic review of quality and consistency of clinical practice guidelines on the primary prevention of food allergy and atopic dermatitis

Background and aims: With an increasing number of Clinical Practice Guidelines (CPGs) addressing primary prevention of food allergy and atopic dermatitis, it is timely to undertake a comprehensive assessment of the quality and consistency of recommendations and evaluation of their implementability in different geographical settings. Methods: We systematically reviewed CPGs from 8 international databases and extensive website searches. Seven reviewers screened records in any language and then used the AGREE II and AGREE REX instruments to critically appraise CPGs published between January 2011 and April 2022. Results: Our search identified 2138 relevant articles, of which 30 CPGs were eventually included. Eight (27%) CPGs were shortlisted based on our predefined quality criteria of achieving scores \u3e70% in the “Scope and Purpose” and “Rigour of Development” domains of the AGREE II instrument. Among the shortlisted CPGs, scores on the “Applicability” domain were generally low, and only 3 CPGs rated highly in the “Implementability” domain of AGREE-REX, suggesting that the majority of CPGs fared poorly on global applicability. Recommendations on maternal diet and complementary feeding in infants were mostly consistent, but recommendations on use of hydrolysed formula and supplements varied considerably. Conclusion: The overall quality of a CPG for Food Allergy and Atopic Dermatitis prevention did not correlate well with its global applicability. It is imperative that CPG developers consider stakeholders’ preferences, local applicability, and adapt existing recommendations to each individual population and healthcare system to ensure successful implementation. There is a need for development of high-quality CPGs for allergy prevention outside of North America and Europe. PROSPERO registration number: CRD42021265689

A systematic review of quality and consistency of clinical practice guidelines on the primary prevention of food allergy and atopic dermatitis

BACKGROUND AND AIMS : With an increasing number of Clinical Practice Guidelines (CPGs) addressing primary prevention of food allergy and atopic dermatitis, it is timely to undertake a comprehensive assessment of the quality and consistency of recommendations and evaluation of their implementability in different geographical settings. METHODS : We systematically reviewed CPGs from 8 international databases and extensive website searches. Seven reviewers screened records in any language and then used the AGREE II and AGREE REX instruments to critically appraise CPGs published between January 2011 and April 2022. RESULTS : Our search identified 2138 relevant articles, of which 30 CPGs were eventually included. Eight (27%) CPGs were shortlisted based on our predefined quality criteria of achieving scores >70% in the “Scope and Purpose” and “Rigour of Development” domains of the AGREE II instrument. Among the shortlisted CPGs, scores on the “Applicability” domain were generally low, and only 3 CPGs rated highly in the “Implementability” domain of AGREE-REX, suggesting that the majority of CPGs fared poorly on global applicability. Recommendations on maternal diet and complementary feeding in infants were mostly consistent, but recommendations on use of hydrolysed formula and supplements varied considerably. CONCLUSION : The overall quality of a CPG for Food Allergy and Atopic Dermatitis prevention did not correlate well with its global applicability. It is imperative that CPG developers consider stakeholders’ preferences, local applicability, and adapt existing individual population and healthcare system to ensure successful implementation. There is a need for development of high-quality CPGs for allergy prevention outside of North America and Europehttps://www.journals.elsevier.com/world-allergy-organization-journal/Paediatrics and Child Healt

Relatório de estágio em farmácia comunitária

Relatório de estágio realizado no âmbito do Mestrado Integrado em Ciências Farmacêuticas, apresentado à Faculdade de Farmácia da Universidade de Coimbr

Use of BIM scenarios by operations services to work with the building information model

Information systems with ever-growing and increasingly complex functionality are being actively introduced into the operation services. In the process of development, the information technology finds new ways to improve efficiency of economic activities for enterprises. However, the use of automated operation control systems in the absence of representation of the construction object as a single system leads to an increase in labor costs and resource losses. There are inefficiently used operation facilities of the maintenance services that have to be solved, including energy efficiency. Many experts of operation do not have enough skills to interact with information model. There is a need to expand the application of BIM beyond construction and design, to learn to use the information obtained at these stages. Automated data collection of BIM can solve such problems with the help of BIM scenario or BIM-use. Each set of works with information about the stage of the life cycle of the project and part of project in international practice is called BIM scenarios. In general, the use of BIM scenarios and information modeling (IM) shows a composite, yet little-researched activity that can provide the necessary effect in maintenance, operation, document management, checking the energy efficiency of the building

Using algorithmic design tools at the stage of building operation

Nowadays automation tools for separate construction processes and transmission of information model between different software frameworks are being developed. Prominent among these are plugins for nodes or visual programming, which are used to solve specific challenges. The procedures of solving them are considered to be possible variants for BIM-scenarios usage. The main goal of the study is demonstration of an example of using algorithmic design for the object operation stage. In this article we formulated and analyzed BIM-scenarios for the building operation stage at the building technical condition monitoring sub-stage and we offered to use tools for algorithmic design to automate implementation of processes of a considered scenario and also formed the main conclusions for the presented study

Side-channel attacks and machine learning approach

Most modern devices and cryptoalgorithms are vulnerable to a new class of attack called side-channel attack. It analyses physical parameters of the system in order to get secret key. Most spread techniques are simple and differential power attacks with combination of statistical tools. Few studies cover using machine learning methods for pre-processing and key classification tasks. In this paper, we investigate applicability of machine learning methods and their characteristic. Following theoretical results, we examine power traces of AES encryption with Support Vector Machines algorithm and decision trees and provide roadmap for further research

Hydration of the Carboxylate Group in Anti-Inflammatory Drugs: ATR-IR and Computational Studies of Aqueous Solution of Sodium Diclofenac

Diclofenac (active ingredient of Voltaren) has a significant, multifaceted role in medicine, pharmacy, and biochemistry. Its physical properties and impact on biomolecular structures still attract essential scientific interest. However, its interaction with water has not been described yet at the molecular level. In the present study, we shed light on the interaction between the steric hindrance (the intramolecular N–H···O bond, etc.) carboxylate group (−CO₂^–) with water. Aqueous solution of sodium declofenac is investigated using attenuated total reflection-infrared (ATR-IR) and computational approaches, i.e., classical molecular dynamics (MD) simulations and density functional theory (DFT). Our coupled classical MD simulations, DFT calculations, and ATR-IR spectroscopy results indicated that the −CO₂^– group of the diclofenac anion undergoes strong specific interactions with the water molecules. The combined experimental and theoretical techniques provide significant insights into the spectroscopic manifestation of these interactions and the structure of the hydration shell of the −CO₂^– group. Moreover, the developed methodology for the theoretical analysis of the ATR-IR spectrum could serve as a template for the future IR/Raman studies of the strong interaction between the steric hindrance −CO₂^– group of bioactive molecules with the water molecules in dilute aqueous solutions