631 research outputs found
CayleyNets: Graph Convolutional Neural Networks with Complex Rational Spectral Filters
The rise of graph-structured data such as social networks, regulatory
networks, citation graphs, and functional brain networks, in combination with
resounding success of deep learning in various applications, has brought the
interest in generalizing deep learning models to non-Euclidean domains. In this
paper, we introduce a new spectral domain convolutional architecture for deep
learning on graphs. The core ingredient of our model is a new class of
parametric rational complex functions (Cayley polynomials) allowing to
efficiently compute spectral filters on graphs that specialize on frequency
bands of interest. Our model generates rich spectral filters that are localized
in space, scales linearly with the size of the input data for
sparsely-connected graphs, and can handle different constructions of Laplacian
operators. Extensive experimental results show the superior performance of our
approach, in comparison to other spectral domain convolutional architectures,
on spectral image classification, community detection, vertex classification
and matrix completion tasks
Global Entrepreneurship Monitor United Kingdom: 2007 Executive Report
This monitoring report compares Global Entrepreneurship Monitor (GEM) measures of entrepreneurial activity in the UK with participating G7 countries and the large industrialised or industrialising countries of Brazil, Russia, India and China ("BRIC"). It also summarises entrepreneurial activity within Government Office Regions of the UK
Leveraging Entrepreneurial Ambition and Innovation : A Global Perspective on Entrepreneurship, Competitiveness and Development
The study described in this report combines two unique datasets, the World Economic Forum’s Global Competitiveness Index data, which ranks the economic competitiveness of 144 economies, and Global Entrepreneurship Monitor’s assessment of entrepreneurial activity across 70 economies. Using five years of data from both sets, the study analyses a sample of 44 economies by first examining three aspects of entrepreneurial activity, then grouping economies into five types of entrepreneurial clusters, and finally developing a deeper understanding of each type of cluster. Lastly, the study delves into what policymaking best benefits the unique characteristics of different economies
Response to Letter to the Editor: "Association of Maternal Iodine Status With Child IQ: A Meta-Analysis of Individual Participant Data"
Response to Letter to the Editor: "Association of Maternal Iodine Status With Child IQ: A Meta-Analysis of Individual Participant Data"
Response to Letter to the Editor: "Association of Maternal Iodine Status With Child IQ: A Meta-Analysis of Individual Participant Data"
Response to Letter to the Editor: "Association of Maternal Iodine Status With Child IQ: A Meta-Analysis of Individual Participant Data"
Response to Letter to the Editor: Association of Maternal Iodine Status With Child IQ: A Meta-Analysis of Individual Participant Data
GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models.
NMDA receptors (NMDARs) play subunit-specific roles in synaptic function and are implicated in neuropsychiatric and neurodegenerative disorders. However, the in vivo consequences and therapeutic potential of pharmacologically enhancing NMDAR function via allosteric modulation are largely unknown. We examine the in vivo effects of GNE-0723, a positive allosteric modulator of GluN2A-subunit-containing NMDARs, on brain network and cognitive functions in mouse models of Dravet syndrome (DS) and Alzheimer's disease (AD). GNE-0723 use dependently potentiates synaptic NMDA receptor currents and reduces brain oscillation power with a predominant effect on low-frequency (12-20 Hz) oscillations. Interestingly, DS and AD mouse models display aberrant low-frequency oscillatory power that is tightly correlated with network hypersynchrony. GNE-0723 treatment reduces aberrant low-frequency oscillations and epileptiform discharges and improves cognitive functions in DS and AD mouse models. GluN2A-subunit-containing NMDAR enhancers may have therapeutic benefits in brain disorders with network hypersynchrony and cognitive impairments
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