Electroacupuncture provides a new approach to neuroprotection in rats with induced glaucoma

Objectives: To investigate, using multifocal electroretinogram (mfERG), the effect of electroacupuncture (EA) on retinal function in rats with experimental glaucoma. Design and subjects: Glaucoma was induced in the right eyes of 15 adult female Sprague-Dawley rats by laser photocoagulation for three quarters of the perilimbal and episcleral vessels. The left eye of each rat was used as the control. The animals were divided into 3 groups: no treatment (non-EA control group), 2 Hz EA group, and 100 Hz EA group. EA treatment at different frequencies can produce different levels of analgesia and hence the effect of EA with different frequencies on glaucoma treatment was investigated. Both eyes of each rat in the EA experimental groups received 3 EA treatment sessions each week for 4 weeks. The retinal function was measured using mfERG after 4 weeks of EA treatment. Results: There was no significant difference in the amplitude (both N1 trough and P1 peak) of mfERG first- order kernel response between the treatment and control groups. In determining the waveform characteristics by the ratio of N1 amplitude to P1 amplitude (N/P ratio), obvious differences were found in the N/P ratio between the control eyes and the glaucoma eyes in the non-EA group and the 100 Hz EA treatment group, but similar values in the N/P ratio were observed between the control eyes and the glaucoma eyes in the 2 Hz EA treatment group. The waveform from the eyes with glaucoma was deformed in both the non-EA group and the 100 Hz EA group, but the waveform from the glaucomatous eye was preserved in the 2 Hz EA group. Conclusions: Application of EA at 2 Hz provides neuroprotection by preserving retinal function in rats with experimental glaucoma. Low frequency EA may be an alternative therapy in the treatment of glaucoma. © Mary Ann Liebert, Inc.published_or_final_versio

Method of treating a rheumatic disorder using combination of transcutaneous electrical nerve stimulation and a ginsenoside

US8855759; US8855759 B2; US8855759B2; US8,855,759; US 8,855,759 B2; 8855759; Appl. No. 11/907,010US2014-2015 > Other Outputs > Patents grantedVersion of Recor

Morphological studies of nitric oxide synthase in hamster retina

Acta Physiologica Scandinavia, 1999, v. 167 n.2 - Proceedings of the Scandinavian Physiological Society meeting in Umea, 28-30 May 1999

Effects of low level laser treatment on the survival of axotomized retinal ganglion cells in adult Hamsters

202012 bcrcVersion of RecordPublishe

Acupressure for agitation in nursing home residents with dementia: Study protocol for a randomized controlled trial

2014-2015 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Effects of low level laser treatment on the survival of axotomized retinal ganglion cells in adult hamsters

published_or_final_versio

Therapeutic low energy laser improves the mechanical strength of repairing medial collateral ligament

Background and Objectives: Low energy laser therapy has been shown to enhance collagen production but its effect on tissue strength is not well reported. We tested the effects of therapeutic laser on the strength of healing medial collateral ligaments (MCLs) in rats. Study Design/Materials and Methods: Twenty-four rats received surgical transection to their right MCL and eight received sham operation. After surgery, 16 received a single dose of gallium aluminum arsenide laser to their transected MCL for 7.5 minutes (n = 8) or 15 minutes (n = 8) and eight served as control with placebo laser, while the sham group didn't receive any treatment. The MCLs were biomechanically tested at either 3 or 6 weeks post-operation. Results: The normalized ultimate tensile strength (UTS) and stiffness of laser and sham groups were larger than control (P < 0.001). The UTS of laser and sham groups were comparable. Laser and sham groups had improved in stiffness from 3 to 6 weeks (P < 0.001). Conclusions: A single dose of low energy laser therapy improves the UTS and stiffness of repairing MCL at 3 and 6 weeks after injury. © 2002 Wiley-Liss, Inc.link_to_subscribed_fulltex

Treatment of experimentally induced transient cerebral ischemia with low energy laser inhibits nitric oxide synthase activity and up-regulates the expression of transforming growth factor-beta 1

Background and Objectives: Nitric oxide (NO) has been shown to be neurotoxic while transforming growth factor-beta 1 (TGF-β1) is neuroprotective in the stroke model. The present study investigates the effects of low energy laser on nitric oxide synthase (NOS) and TGF-β1 activities after cerebral ischemia and reperfusion injury. Study Design/Materials and Methods: Cerebral ischemia was induced for 1 hour in male adult Sprague-Dawley (S.D.) rats with unilateral occlusion of middle cerebral artery (MCAO). Low energy laser irradiation was then applied to the cerebrum at different durations (1, 5, or 10 minutes). The activity of NOS and the expression of TGF-β1 were evaluated in groups with different durations of laser irradiation. Results: After ischemia, the activity of NOS was gradually increased from day 3, became significantly higher from day 4 to 6 (P < 0.001), but returned to the normal level after day 7. The activity and expression of the three isoforms of NOS were significantly suppressed (P < 0.001) to different extents after laser irradiation. In addition, laser irradiation was shown to trigger the expression of TGF-β1 (P < 0.001). Conclusions: Low energy laser could suppress the activity of NOS and up-regulate the expression of TGF-β1 after stroke in rats. © 2002 Wiley-Liss, Inc.link_to_subscribed_fulltex