Dust emission by powder handling: Influence of the hopper outlet on the dust plume

Dust generation in solids handling involving free fall of bulk materials and impacts on a stockpile can cause many problems in industry and be a great danger for operators health. This paper describes an experimental set up to characterize the dust plume formed in free fall of powders from a hopper and investigates the influence of various outlet geometries on the dust plume. For this purpose an image analysis technique was developed to quantify the characteristics of the dust plume

Delayed neutrons measurement at the MEGAPIE target

In the framework of the Neutronic and Nuclear Assessment Task Group of the MEGAPIE experiment we measured the delayed neutron (DN) flux at the top of the target. The measurement was proposed mainly for radioprotection purposes since the DN flux at the top of the target has been estimated to be of the same order of magnitude as the prompt neutron flux. Given the strong model-dependence of DN predictions, the measurement of DN contribution to the total neutron activity at the top of the target was thus desired. Moreover, this measurement is complementary to the DN experiments performed at PNPI (Gatchina) on solid lead and bismuth targets. The DN measurement at MEGAPIE was performed during the start-up phase of the target. In this paper we present a detailed description of the experimental setup and some preliminary results on decay spectra.Comment: 4 pages, 4 figures, Proceedings of International Conference on Nuclear Data for Science and Technology (ND 2007), Nice, France, 22-27 Apr 200

A proposed search for a fourth neutrino with a PBq antineutrino source

Several observed anomalies in neutrino oscillation data can be explained by a hypothetical fourth neutrino separated from the three standard neutrinos by a squared mass difference of a few eV^2. We show that this hypothesis can be tested with a PBq (ten kilocurie scale) 144Ce or 106Ru antineutrino beta-source deployed at the center of a large low background liquid scintillator detector. In particular, the compact size of such a source could yield an energy-dependent oscillating pattern in event spatial distribution that would unabiguously determine neutrino mass differences and mixing angles.Comment: 4 pages ; 1 table ; 4 figures - Add energy spectrum shape only analysis + referee comments/suggestion

Reactive oxygen species-dependent Toll/ NF-kB activation in the Drosophila hematopoietic niche confers resistance to wasp parasitism

International audienceHematopoietic stem/progenitor cells in the adult mammalian bone marrow ensure blood cell renewal. Their cellular microenvironment, called 'niche', regulates hematopoiesis both under homeostatic and immune stress conditions. In the Drosophila hematopoietic organ, the lymph gland, the posterior signaling center (PSC) acts as a niche to regulate the hematopoietic response to immune stress such as wasp parasitism. This response relies on the differentiation of lamellocytes, a cryptic cell type, dedicated to pathogen encapsulation and killing. Here, we establish that Toll/NF-kB pathway activation in the PSC in response to wasp parasitism non-cell autonomously induces the lymph gland immune response. Our data further establish a regulatory network where co-activation of Toll/NF-kB and EGFR signaling by ROS levels in the PSC/niche controls lymph gland hematopoiesis under parasitism. Whether a similar regulatory network operates in mammals to control emergency hematopoiesis is an open question

A comprehensive revision of the summation method for the prediction of reactor antineutrino fluxes and spectra

The summation method for the calculation of reactor $\bar{\nu}_e$ fluxes and spectra is methodically revised and improved. For the first time, a complete uncertainty budget accounting for all known effects likely to impact these calculations is proposed. Uncertainties of a few percents at low energies and ranging up to 20% at high energies are obtained on the calculation of a typical reactor $\bar{\nu}_e$ spectrum. Although huge improvements have been achieved over the past decade, the quality and incompleteness of the present day evaluated nuclear decay data still limit the accuracy of the calculations and therefore dominate by far these uncertainties. Pushing the $\beta$-decay modeling of the thousands of branches making a reactor $\bar{\nu}_e$ spectrum to a high level of details comparatively brings modest changes. In particular, including nuclear structure calculations in the evaluation of the non-unique forbidden transitions gives a smaller impact than anticipated in past studies. Finally, this new modeling is challenged against state-of-the-art predictions and measurements. While a good agreement is observed with the most recent Inverse Beta Decay measurements of reactor $\bar{\nu}_e$ fluxes and spectra, it is unable to properly describe the reference aggregate $\beta$ spectra measured at the Institut Laue-Langevin High-Flux reactor in the 80s. This result adds to recent suspicions $\beta$ the reliability of these data and preferentially points toward a misprediction of the $^{235}$U $\bar{\nu}_e$ spectrum.Comment: 34 pages, 16 figures. Submitted to PR

Evaluation of pulmonary perfusion by SPECT imaging using an endothelial cell tracer in supine humans and dogs.

International audiencePulmonary perfusion is not spatially homogeneously distributed, and its variations could be of diagnostic value in lung vascular disease. PulmoBind is a ligand of the adrenomedullin receptor densely expressed in endothelial cells of lung capillaries. The aim of this study was to evaluate spatial distribution of human lung perfusion by using this novel molecular tracer of the pulmonary vascular endothelium. Normal humans (n = 19) enrolled into the PulmoBind phase I trial were studied (Clinicaltrials.gov. NCT01539889 ). They were injected with (99m)Tc-PulmoBind for SPECT imaging. Results were compared with (99m)Tc-PulmoBind in quadruped mammals (dogs, n = 5). Imaging was performed in the supine position and distribution of activity was determined as a function of cumulative voxels along the different anatomical planes. PulmoBind uptake in humans was 58 ± 1 % (mean ± SEM) of the injected dose. Dorsal activity was 18.1 ± 2.1 % greater than ventral, and caudal activity was 25.7 ± 1.6 % greater than cranial. Lateral activity was only mildly higher than medial by 7.0 ± 1.0 %. In supine dogs, similar but higher PulmoBind gradients were present: dorsal 28.6 ± 2.5 %, caudal 34.1 ± 5.0 % and lateral 18.1 ± 2.0 %. The perfused pulmonary circulation of supine humans, assessed by an adrenomedullin receptor ligand, is not homogeneously distributed with more prominent distribution in dorsal and caudal regions. It is qualitatively similar to a supine quadruped mammal confirming the presence of a microcirculatory gravitational perfusion gradient detectable with this tracer. Future studies are needed to determine if this novel endothelial cell tracer could be used to detect physiologic and pathologic variations of lung perfusion such as in pulmonary hypertension. ClinicalTrial.gov, NCT01539889

PulmoBind Imaging Measures Reduction of Vascular Adrenomedullin Receptor Activity with Lack of effect of Sildenafil in Pulmonary Hypertension

International audienceEndothelial dysfunction is a core pathophysiologic process in pulmonary arterial hypertension (PAH). We developed PulmoBind (PB), a novel imaging biomarker of the pulmonary vascular endothelium. 99mTechnetium (99mTc)-labelled PB binds to adrenomedullin receptors (AM1) densely expressed in the endothelium of alveolar capillaries. We evaluated the effect of sildenafil on AM1 receptors activity using 99mTc-PB. PAH was induced in rats using the Sugen/hypoxia model and after 3 weeks, animals were allocated to sildenafil (25 or 100 mg/kg/day) for 4 weeks. 99mTc-PB uptake kinetics was assessed by single-photon emission computed tomography. PAH caused right ventricular (RV) hypertrophy that was decreased by low and high sildenafil doses. Sildenafil low and high dose also improved RV function measured from the tricuspid annulus plane systolic excursion. Mean integrated pulmonary uptake of 99mTc-PB was reduced in PAH (508% · min ± 37, p < 0.05) compared to controls (630% · min ± 30), but unchanged by sildenafil at low and high doses. Lung tissue expressions of the AM1 receptor components were reduced in PAH and also unaffected by sildenafil. In experimental angio-proliferative PAH, sildenafil improves RV dysfunction and remodeling, but does not modify pulmonary vascular endothelium dysfunction assessed by the adrenomedullin receptor ligand 99mTc-PB