Dehydroepiandrosterone modulates endothelial nitric oxide synthesis via direct genomic and nongenomic mechanisms.

Abstract Dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) are the major circulating steroid hormones in humans, and their levels progressively decline with age. Epidemiological studies suggest that DHEA/DHEAS concentrations may be inversely related to cardiovascular risk, but disagreement exists on this issue. Preliminary studies show that DHEA regulates vascular function, but few data have been published on the mechanisms. We show that DHEA administration to human endothelial cells triggers nitric oxide synthesis, due to enhanced expression and stabilization of endothelial nitric oxide synthase (eNOS). Additionally, DHEA rapidly activates eNOS, through a nontranscriptional mechanism that depends on ERK1/2 MAPK, but not on phosphatidylinositol 3-kinase/Akt. DHEA is not converted to estrogens or androgens by endothelial cells, and its genomic and nongenomic effects are not blocked by antagonists of the estrogen, progesterone, glucocorticoid, or androgen receptors, suggesting that DHEA acts through a specific receptor. Oral DHEA administration to ovariectomized Wistar rats dose-dependently restores aortic eNOS levels and eNOS activity, confirming the effects of DHEA in vivo. Our present data suggest that DHEA may have direct genomic and nongenomic effects on the vascular wall that are not mediated by other steroid hormone receptors, leading to eNOS activation and induction

Sustainability of compact cities: the SOS_UrbanLab activity

Urban development is facing new challenges to allow the evolution of the environment, in accordance to sustainability principles. In this context, decision makers have to answer to three main issues: how to intervene on the existing compact cities? How to combine and develop interventions on different scales? How to move from requalification to regeneration? The SOS_UrbanLab (Engineering Laboratory for Construction and Environmental Sustainability) researches, starting from a multi-scale analysis, propose a set of eco-friendly solutions to support the potential and capability of territories, integrating their benefits to reach a full sustainable approach

A case of primitive amyloid goiter

Amyloid goiter is a rare pathology due to massive amyloid infiltration of thyroid tissue, which cause diffuse or localized enlargement of the gland. It can be totally asymptomatic or cause only non-specific symptoms (compression of adjacent structures, tracheal deviation). Thyroid disfunction (hypothyroidism or hyperthyroidism) is rare. It is important to differentiate primitive amyloid goiter from other kinds of amyloid infiltration of the thyroid, such as in systemic amyloidosis. The correct diagnosis can be difficult because of the common presence of amyloid in thyroid neoplasms, such as medullary thyroid carcinoma (MTC). The Authors present a case of primitive amyloid goiter, that needed immunohistochemical analysis for a correct diagnosis, and a review of the concerning literature

Città compatte sostenibili: l'attività del SOS_URBANLAB

Lo sviluppo urbano si trova ad affrontare nuove sfide per consentire l'evoluzione dell'ambiente secondo i principi di sostenibilità. In questo contesto, i decision maker devono rispondere a tre quesiti principali: come intervenire sulle città esistenti compatte? Come sviluppare e combinare interventi su scale diverse? Come passare da riqualificazione a rigenerazione? Le ricerche del SOS_UrbanLab (Laboratorio di Ingegneria per la Sostenibilità Edilizia e Ambientale) propongono una serie di soluzioni eco-compatibili per lo sviluppo delle potenzialità dei territori, integrandone i benefici secondo un approccio sostenibile e multi-scalare