Genomic sequences used in this study.

<p>The table shows general information about the genomic sequences of the ASFV strains used in this study. Left and right indicates the size of the left and right genome variable regions. The left variable region includes the nucleotides from the 5’- end of the genome until gene A224L, whereas the right variable region includes the nucleotides from the 3’- end of the genome until gene DP238L.</p><p>Genomic sequences used in this study.</p

Comparison of the genomic structure of BA71 with BA71V and OURT88/3 around difference 49.

<p>The figure shows a representation to scale of the genomes of BA71, BA71V and OURT88/3 around the position of BA71-BA71V difference 49 (the exact positions are indicated for each of the genomes). Red arrows delimit non-identical regions. Blue lines connect arrows at equivalent positions. The different groups of ORFs are identified by colors as shown in the figure. The dash at the beginning of the names of some ORFs indicates where the prefix BA71- has been removed to avoid clutter.</p

Differences between BA71 and BA71V: changes in polynucleotide sequences.

<p>The position of the differences in each genome is indicated along with the size of the change, in brackets. The nature of the polynucleotide and the ORF affected, if any, are also indicated.</p><p>Differences between BA71 and BA71V: changes in polynucleotide sequences.</p

5’- and 3’- ends of the ASFV BA71 and BA71V genomes.

<p>The figure shows dot plot comparisons of the 5’- (A) and 3’-end (B) variable regions. For each of the four large deletions observed between the genomes, the deleted region is indicated by a light blue box in the corresponding axis and the position where the deletion occurred is indicated by an arrow in the opposite axis. ORFs are indicated by arrows, and the different groups of ORFs are identified by colors: MGF 360, violet; MGF 110, yellow; MGF 300, green; MGF 505, red; MGF 100, rose; p22 family, gray, other ORFs, black.</p

Genes and polymorphisms associated with overall survival (OS) and event free survival (EFS).

<p>*HR: Hazard Ratio.</p><p>**Analysis adjusted for metastasis at diagnosis.</p

Kaplan-Meier survival curves for osteosarcoma patients according to genotype for (A) rs4148416 in <i>ABCC3</i> (X² = 21.4, <i>p-value</i> = 3.8×10⁻⁶); (B) rs4148737 in <i>ABCB1</i> (X² = 18.4, <i>p-value</i> = 1.0×10⁻⁴); and (C) rs1128503 or rs10276036 in <i>ABCB1</i> (X² = 20.9, <i>p-value</i> = 2.9×10⁻⁵<i>).</i>

<p>Kaplan-Meier survival curves for osteosarcoma patients according to genotype for (A) rs4148416 in <i>ABCC3</i> (X² = 21.4, <i>p-value</i> = 3.8×10⁻⁶); (B) rs4148737 in <i>ABCB1</i> (X² = 18.4, <i>p-value</i> = 1.0×10⁻⁴); and (C) rs1128503 or rs10276036 in <i>ABCB1</i> (X² = 20.9, <i>p-value</i> = 2.9×10⁻⁵<i>).</i></p