The Connex: A New User-Interface Design for the Contacts of a Mobile Phone

Many social media websites including MySpace, AniRoleplay, and Tumblr give users the opportunity to express their personality by customizing the profile. The contact list of an Apple iPhone currently does not allow users to customize features. This project created a new user-interface design for the contact list of an Apple iPhone which draws inspiration from the Pokédex used in the popular Pokémon franchise. By rebranding this fictional device so the core functionality translates into the real world in a practical and original way, users can bring their personality and creative expression to other devices outside the internet. Many key components found within the different iterations of the Pokédex were investigated such as the layout style, color scheme, features, and prominent design elements. Understanding the successes and failures of basic informational features of each Pokédex design iteration was critical to the development of this project and served as the foundation of the Connex application. Taking the design characteristics and functional features of the Pokédex and merging them with the functional features of the Apple iPhone, users were given a new level of freedom, control, and flexibility never yet experienced on a mobile platform. Each user has the ability to change the layout, color scheme, typography, and elemental type classifications which can result in the possibility of no two Connex applications appearing identical. The final iteration of the Connex application meets three core elements. First, it contains a visually friendly user-interface due to the design choices of the developer. Second, it is user friendly due to the attention to detail which was incorporated into the user-interface. Third, it contains the ability for users to customize its features and incorporate their own personality

Transistors et résistances moléculaires à base de phtalocyanine pour la détection de l'ozone

Objectifs et contributions -- L'ozone -- Les phtalocyanines -- Synthèse et caractérisation des phtalocyanines -- Caractéristiques des phtalocyanines -- Conception et fabrication des dispositifs -- Fabrication des dispositifs sans les procédés de la micro-électronique -- Fabrication des dispositifs micro-électroniques -- Étude des propriétés électriques des dispositifs -- Propriétés électriques des capteurs résistifs -- Propriétés électriques des transistors moléculaires -- Influence de l'ozone -- Génération d'ozone et montage d'acquisition -- Influence d'ozone sur les capteurs résistifs -- Influence de l'ozone sur les transistors moléculaire -- Influence de l'ozone sur la surface des films minces de phtalocyanines

Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis

Ewing's sarcoma is a highly aggressive pediatric tumor of bone that usually contains the characteristic chromosomal translocation t(11;22)(q24;q12). This translocation encodes the oncogenic fusion protein EWS/FLI, which acts as an aberrant transcription factor to deregulate target genes necessary for oncogenesis. One key feature of oncogenic transformation is dysregulation of cell cycle control. It is therefore likely that EWS/FLI and other cooperating mutations in Ewing's sarcoma modulate the cell cycle to facilitate tumorigenesis. This paper will summarize current published data associated with deregulation of the cell cycle in Ewing's sarcoma and highlight important questions that remain to be answered

NKX2-2 (NK2 homeobox 2)

Review on NKX2-2 (NK2 homeobox 2), with data on DNA, on the protein encoded, and where the gene is implicated

Glutathione S-Transferases in Pediatric Cancer

The glutathione S-transferases (GSTs) are a family of ubiquitously expressed polymorphic enzymes important for detoxifying endogenous and exogenous compounds. In addition to their classic activity of detoxification by conjugation of compounds with glutathione, many other functions are now found to be associated with GSTs. The associations between GST polymorphisms/functions and human disease susceptibility or treatment outcome, mostly in adults, have been extensively studied and reviewed. This mini review focuses on studies related to GST epidemiology and functions related to pediatric cancer. Opportunities to exploit GST in pediatric cancer therapy are also discussed

Molecular dissection of the mechanism by which EWS/FLI expression compromises actin cytoskeletal integrity and cell adhesion in Ewing sarcoma.

Ewing sarcoma is the second-most-common bone cancer in children. Driven by an oncogenic chromosomal translocation that results in the expression of an aberrant transcription factor, EWS/FLI, the disease is typically aggressive and micrometastatic upon presentation. Silencing of EWS/FLI in patient-derived tumor cells results in the altered expression of hundreds to thousands of genes and is accompanied by dramatic morphological changes in cytoarchitecture and adhesion. Genes encoding focal adhesion, extracellular matrix, and actin regulatory proteins are dominant targets of EWS/FLI-mediated transcriptional repression. Reexpression of genes encoding just two of these proteins, zyxin and α5 integrin, is sufficient to restore cell adhesion and actin cytoskeletal integrity comparable to what is observed when the EWS/FLI oncogene expression is compromised. Using an orthotopic xenograft model, we show that EWS/FLI-induced repression of α5 integrin and zyxin expression promotes tumor progression by supporting anchorage-independent cell growth. This selective advantage is paired with a tradeoff in which metastatic lung colonization is compromised

Increased risk for other cancers in individuals with Ewing sarcoma and their relatives.

BackgroundThere are few reports of the association of other cancers with Ewing sarcoma in patients and their relatives. We use a resource combining statewide genealogy and cancer reporting to provide unbiased risks.MethodsUsing a combined genealogy of 2.3 million Utah individuals and the Utah Cancer Registry (UCR), relative risks (RRs) for cancers of other sites were estimated in 143 Ewing sarcoma patients using a Cox proportional hazards model with matched controls; however, risks in relatives were estimated using internal cohort-specific cancer rates in first-, second-, and third-degree relatives.ResultsCancers of three sites (breast, brain, complex genotype/karyotype sarcoma) were observed in excess in Ewing sarcoma patients. No Ewing sarcoma patients were identified among first-, second-, or third-degree relatives of Ewing sarcoma patients. Significantly increased risk for brain, lung/bronchus, female genital, and prostate cancer was observed in first-degree relatives. Significantly increased risks were observed in second-degree relatives for breast cancer, nonmelanoma eye cancer, malignant peripheral nerve sheath cancer, non-Hodgkin lymphoma, and translocation sarcomas. Significantly increased risks for stomach cancer, prostate cancer, and acute lymphocytic leukemia were observed in third-degree relatives.ConclusionsThis analysis of risk for cancer among Ewing sarcoma patients and their relatives indicates evidence for some increased cancer predisposition in this population which can be used to individualize consideration of potential treatment of patients and screening of patients and relatives