2,801 research outputs found
Estimating the Predictive Value of Negative SARS-CoV-2 Results: A Prospective Study
© 2020 by The Society for Healthcare Epidemiology of America. All rights reserved. We performed a prospective study of 501 patients, regardless of symptoms, admitted to the hospital, to estimate the predictive value of a negative Nasopharyngeal swab for SARS-CoV-2. At a positivity rate of 10.2%, the estimated Negative Predictive Value (NPV) was 97.2% and NPV rose as prevalence decreased during the study
The ATLAS tile calorimeter digitizer
The ATLAS Tile Calorimeter digitizer system samples photomultiplier signals from the scintillating tiles of the hadronic calorimeter. For each channel a pair of 10-bit ADCs digitize high and low gain signals at 40.08 MHz to provide the necessary 16-bit dynamic range. The sampled data is temporarily stored in digital pipelines for up to 6.375 \mus, awaiting a level-1 accept. For each accept received, the corresponding sampled pulse is transferred to a derandomizer buffer for subsequent readout to the data acquisition system (DAQ). The main functionality of the digitizer is implemented in radiation tolerant ASICs, using a fault tolerant architecture to minimize the consequences of radiation induced faults
Abnormalities in autonomic function in obese boys at-risk for insulin resistance and obstructive sleep apnea.
Study objectivesCurrent evidence in adults suggests that, independent of obesity, obstructive sleep apnea (OSA) can lead to autonomic dysfunction and impaired glucose metabolism, but these relationships are less clear in children. The purpose of this study was to investigate the associations among OSA, glucose metabolism, and daytime autonomic function in obese pediatric subjects.MethodsTwenty-three obese boys participated in: overnight polysomnography; a frequently sampled intravenous glucose tolerance test; and recordings of spontaneous cardiorespiratory data in both the supine (baseline) and standing (sympathetic stimulus) postures.ResultsBaseline systolic blood pressure and reactivity of low-frequency heart rate variability to postural stress correlated with insulin resistance, increased fasting glucose, and reduced beta-cell function, but not OSA severity. Baroreflex sensitivity reactivity was reduced with sleep fragmentation, but only for subjects with low insulin sensitivity and/or low first-phase insulin response to glucose.ConclusionsThese findings suggest that vascular sympathetic activity impairment is more strongly affected by metabolic dysfunction than by OSA severity, while blunted vagal autonomic function associated with sleep fragmentation in OSA is enhanced when metabolic dysfunction is also present
Internal Color Properties of Resolved Spheroids in the Deep HST/ACS field of UGC 10214
(Abridged) We study the internal color properties of a morphologically
selected sample of spheroidal galaxies taken from HST/ACS ERO program of UGC
10214 (``The Tadpole''). By taking advantage of the unprecedented high
resolution of the ACS in this very deep dataset we are able to characterize
spheroids at sub-arcseconds scales. Using the V_606W and I_814W bands, we
construct V-I color maps and extract color gradients for a sample of spheroids
at I_814W < 24 mag. We investigate the existence of a population of
morphologically classified spheroids which show extreme variation in their
internal color properties similar to the ones reported in the HDFs. These are
displayed as blue cores and inverse color gradients with respect to those
accounted from metallicity variations. Following the same analysis we find a
similar fraction of early-type systems (~30%-40%) that show non-homologous
internal colors, suggestive of recent star formation activity. We present two
statistics to quantify the internal color variation in galaxies and for tracing
blue cores, from which we estimate the fraction of non-homogeneous to
homogeneous internal colors as a function of redshift up to z<1.2. We find that
it can be described as about constant as a function of redshift, with a small
increase with redshift for the fraction of spheroids that present strong color
dispersions. The implications of a constant fraction at all redshifts suggests
the existence of a relatively permanent population of evolving spheroids up to
z~1. We discuss the implications of this in the context of spheroidal
formation.Comment: Fixed URL for high resolution version. 13 Pages, 10 Figures. Accepted
for Publication in ApJ. Sep 1st issue. Higher resolution version and complete
table3B at http://acs.pha.jhu.edu/~felipe/e-prints/Tadpol
Advanced Camera for Surveys Observations of Young Star Clusters in the Interacting Galaxy UGC 10214
We present the first Advanced Camera for Surveys (ACS) observations of young
star clusters in the colliding/merging galaxy UGC 10214. The observations were
made as part of the Early Release Observation (ERO) program for the newly
installed ACS during service mission SM3B for the Hubble Space Telescope (HST).
Many young star clusters can be identified in the tails of UGC 10214, with ages
ranging from ~3 Myr to 10 Myr. The extreme blue V-I (F606W-F814W) colors of the
star clusters found in the tail of UGC 10214 can only be explained if strong
emission lines are included with a young stellar population. This has been
confirmed by our Keck spectroscopy of some of these bright blue stellar knots.
The most luminous and largest of these blue knots has an absolute magnitude of
M_V = -14.45, with a half-light radius of 161 pc, and if it is a single star
cluster, would qualify as a super star cluster (SSC). Alternatively, it could
be a superposition of multiple scaled OB associations or clusters. With an
estimated age of ~ 4-5 Myr, its derived mass is < 1.3 x 10^6 solar masses. Thus
the young stellar knot is unbound and will not evolve into a normal globular
cluster. The bright blue clusters and associations are much younger than the
dynamical age of the tail, providing strong evidence that star formation occurs
in the tail long after it was ejected. UGC 10214 provides a nearby example of
processes that contributed to the formation of halos and intra-cluster media in
the distant and younger Universe.Comment: 6 pages with embedded figures, ApJ in pres
Spectrum and clinical significance of systolic function and myocardial fibrosis assessed by cardiovascular magnetic resonance in hypertrophic cardiomyopathy
Discovery of Globular Clusters in the Proto-Spiral NGC2915: Implications for Hierarchical Galaxy Evolution
We have discovered three globular clusters beyond the Holmberg radius in
Hubble Space Telescope Advanced Camera for Surveys images of the gas-rich dark
matter dominated blue compact dwarf galaxy NGC2915. The clusters, all of which
start to resolve into stars, have M_{V606} = -8.9 to -9.8 mag, significantly
brighter than the peak of the luminosity function of Milky Way globular
clusters. Their colors suggest a metallicity [Fe/H] ~ -1.9 dex, typical of
metal-poor Galactic globular clusters. The specific frequency of clusters is at
a minimum normal, compared to spiral galaxies. However, since only a small
portion of the system has been surveyed it is more likely that the luminosity
and mass normalized cluster content is higher, like that seen in elliptical
galaxies and galaxy clusters. This suggests that NGC2915 resembles a key phase
in the early hierarchical assembly of galaxies - the epoch when much of the old
stellar population has formed, but little of the stellar disk. Depending on the
subsequent interaction history, such systems could go on to build-up larger
elliptical galaxies, evolve into normal spirals, or in rare circumstances
remain suspended in their development to become systems like NGC2915.Comment: ApJ Letters accepted; 6 pages, 2 figures, 3 table
The Luminosity Function of Early-Type Galaxies at z~0.75
We measure the luminosity function of morphologically selected E/S0 galaxies
from to using deep high resolution Advanced Camera for Surveys
imaging data. Our analysis covers an area of 48\Box\arcmin (8 the
area of the HDF-N) and extends 2 magnitudes deeper ( mag) than was
possible in the Deep Groth Strip Survey (DGSS). At , we find
and , and at
, we find . These luminosity
functions are similar in both shape and number density to the luminosity
function using morphological selection (e.g., DGSS), but are much steeper than
the luminosity functions of samples selected using morphological proxies like
the color or spectral energy distribution (e.g., CFRS, CADIS, or COMBO-17). The
difference is due to the `blue', , E/S0 galaxies, which make up to
of the sample at all magnitudes and an increasing proportion of faint
galaxies. We thereby demonstrate the need for {\it both morphological and
structural information} to constrain the evolution of galaxies.
We find that the `blue' E/S0 galaxies have the same average sizes and Sersic
parameters as the `red', , E/S0 galaxies at brighter luminosities
(), but are increasingly different at fainter magnitudes where
`blue' galaxies are both smaller and have lower Sersic parameters. Fits of the
colors to stellar population models suggest that most E/S0 galaxies have short
star-formation time scales ( Gyr), and that galaxies have formed at an
increasing rate from until after which there has been a
gradual decline.Comment: 39 pages, 21 figures, accepted in A
Comparative Survival Analysis of Immunomodulatory Therapy for Coronavirus Disease 2019 Cytokine Storm.
BACKGROUND:Cytokine storm is a marker of coronavirus disease 2019 (COVID-19) illness severity and increased mortality. Immunomodulatory treatments have been repurposed to improve mortality outcomes. RESEARCH QUESTION:Do immunomodulatory therapies improve survival in patients with COVID-19 cytokine storm (CCS)? STUDY DESIGN AND METHODS:We conducted a retrospective analysis of electronic health records across the Northwell Health system. COVID-19 patients hospitalized between March 1, 2020, and April 24, 2020, were included. CCS was defined by inflammatory markers: ferritin, \u3e 700 ng/mL; C-reactive protein (CRP), \u3e 30 mg/dL; or lactate dehydrogenase (LDH), \u3e 300 U/L. Patients were subdivided into six groups: no immunomodulatory treatment (standard of care) and five groups that received either corticosteroids, anti-IL-6 antibody (tocilizumab), or anti-IL-1 therapy (anakinra) alone or in combination with corticosteroids. The primary outcome was hospital mortality. RESULTS:Five thousand seven hundred seventy-six patients met the inclusion criteria. The most common comorbidities were hypertension (44%-59%), diabetes (32%-46%), and cardiovascular disease (5%-14%). Patients most frequently met criteria with high LDH (76.2%) alone or in combination, followed by ferritin (63.2%) and CRP (8.4%). More than 80% of patients showed an elevated D-dimer. Patients treated with corticosteroids and tocilizumab combination showed lower mortality compared with patients receiving standard-of-care (SoC) treatment (hazard ratio [HR], 0.44; 95% CI, 0.35-0.55; P \u3c .0001) and with patients treated with corticosteroids alone (HR, 0.66; 95% CI, 0.53-0.83; P = .004) or in combination with anakinra (HR, 0.64; 95% CI, 0.50-0.81; P = .003). Corticosteroids when administered alone (HR, 0.66; 95% CI, 0.57-0.76; P \u3c .0001) or in combination with tocilizumab (HR, 0.43; 95% CI, 0.35-0.55; P \u3c .0001) or anakinra (HR, 0.68; 95% CI, 0.57-0.81; P \u3c .0001) improved hospital survival compared with SoC treatment. INTERPRETATION:The combination of corticosteroids with tocilizumab showed superior survival outcome when compared with SoC treatment and treatment with corticosteroids alone or in combination with anakinra. Furthermore, corticosteroid use either alone or in combination with tocilizumab or anakinra was associated with reduced hospital mortality for patients with CCS compared with patients receiving SoC treatment
Star Formation at z~6: i-dropouts in the ACS GTO fields
Using an i-z dropout criterion, we determine the space density of z~6
galaxies from two deep ACS GTO fields with deep optical-IR imaging. A total of
23 objects are found over 46 arcmin^2, or ~0.5 objects/arcmin^2 down to z~27.3
(6 sigma; all AB mag) (including one probable z~6 AGN). Combining deep ISAAC
data for our RDCS1252-2927 field (J~25.7 and Ks~25.0 (5 sigma)) and NICMOS data
for the HDF North (JH~27.3 (5 sigma)), we verify that these dropouts have flat
spectral slopes. i-dropouts in our sample range in luminosity from ~1.5 L*
(z~25.6) to ~0.3 L* (z~27.3) with the exception of one very bright candidate at
z~24.2. The half-light radii vary from 0.09" to 0.29", or 0.5 kpc to 1.7 kpc.
We derive the z~6 rest-frame UV luminosity density using three different
procedures, each utilizing simulations based on a CDF South V dropout sample.
First, we compare our findings with a no-evolution projection of this V-dropout
sample. We find 23+/-25% more i-dropouts than we predict. Adopting previous
results to z~5, this works out to a 20+/-29% drop in the luminosity density
from z~3 to z~6. Second, we use these same V-dropout simulations to derive a
selection function for our i-dropout sample and compute the UV-luminosity
density (7.2+/-2.5 x 10^25 ergs/s/Hz/Mpc^3 down to z~27). We find a 39+/-21%
drop over the same redshift range. This is our preferred value and suggests a
star formation rate of 0.0090+/-0.0031 M_sol/yr/Mpc^3 to z~27, or ~0.036+/-
0.012 M_sol/yr/Mpc^3 extrapolating the LF to the faint limit. Third, we follow
a very similar procedure, but assume no incompleteness, finding a luminosity
density which is ~2-3X lower. This final estimate constitutes a lower limit.
All three estimates are within the canonical range of luminosity densities
necessary for reionization of the universe at this epoch. (abridged)Comment: 36 pages, 13 figures, 2 tables, accepted for publication in ApJ,
postscript version with high-resolution figures can be downloaded at
http://www.ucolick.org/~bouwens/idropout.p
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