Softversko rešenje za određivanje čitljivosti analognih vizuelnih pokazivača sa kružnom skalom

Verifikovano tehničko rešenj

Evaluation of an Optimal Width of a Rear Seat of Sedans

A relatively large number of papers have been published on the topic of designing and evaluation of ergonomic convenience of the driver's seat of passenger cars. However, in the scientific and technical literature, it is extremely difficult to find an article that relates to the anthropometric determination of the width of the rear seats of sedans. The primary objective of this article is to consider the possibilities of positioning of passengers with different anthropometric dimensions on the rear seat of sedans. To make this possible, the research was necessary to start with the analysis of the current situation in the global auto industry from the aforementioned aspect. Analytical procedure was initiated by specifying the identical maximal percentiles of persons that can be accommodated on the rear seat of selected models of sedans. An additional, more complex analysis has included different combinations of accommodation of adults and children. Different combinations of 55 human dimensions and the possibilities of their positioning in various types of sedans were considered. This analysis was the basis that enabled the creation of diagrams of comfortable accommodation of passengers, depending on the width of the available space on the rear seat of a sedan

Transplantation of allogeneic T cells alters iron homeostasis in NOD/SCID mice

Iron overload is common in patients undergoing allogeneic hematopoietic cell transplantation (HCT), but the mechanisms leading to overload are unknown. Here, we determined iron levels and the expression of iron regulatory proteins in the liver and gut of nonobese diabetic–severe combined immunodeficient (NOD/SCID) mice that underwent transplantation with syngeneic (histocompatible) or allogeneic (histoincompatible) T lymphocytes. Infusion of histoincompatible T cells resulted in a significant rise in serum iron levels and liver iron content. Iron deposition was accompanied by hepatocyte injury and intestinal villous damage. Feeding of low- or high-iron diet was associated with appropriate ferroportin 1 and hepcidin responses in mice given histocompatible T cells, whereas mice given histoincompatible T cells showed inappropriate up-regulation of duodenal ferroportin 1 and a loss of expression of hepatic hepcidin. These findings suggest that alloreactive T cell–dependent signals induced dysregulation of intestinal iron absorption, which contributed to liver iron overload after HCT

Diluted Magnetic Semiconductors InFeSb Prepared by Laser Ablation: Spectroscopic and Microscopic Investigations

We report optical and magneto-optical results as well as atomic force microscopy (AFM) and magnetic force microscopy (MFM) results for InFeSb samples prepared by laser ablation. AFM and MFM studies have revealed the presence of magnetic particles on the samples surface, whose sizes depend on the Fe content and substrate temperature. It has found that both optical and magneto-optical spectra are superposition of spectra from the doped InFeSb layers and particles on their surface

Diluted Magnetic Semiconductors InFeSb Prepared by Laser Ablation: Spectroscopic and Microscopic Investigations

We report optical and magneto-optical results as well as atomic force microscopy (AFM) and magnetic force microscopy (MFM) results for InFeSb samples prepared by laser ablation. AFM and MFM studies have revealed the presence of magnetic particles on the samples surface, whose sizes depend on the Fe content and substrate temperature. It has found that both optical and magneto-optical spectra are superposition of spectra from the doped InFeSb layers and particles on their surface

NF-κB and FLIP in arsenic trioxide (ATO)-induced apoptosis in myelodysplastic syndromes (MDSs)

Tumor necrosis factor (TNF)-α, a potent stimulus of nuclear factor-κB (NF-κB), is up-regulated in myelodysplastic syndrome (MDS). Here, we show that bone marrow mononuclear cells (BMMCs) and purified CD34+ cells from patients with low-grade/early-stage MDS (refractory anemia/refractory anemia with ring sideroblasts [RA/RARS]) have low levels of NF-κB activity in nuclear extracts comparable with normal marrow, while patients with RA with excess blasts (RAEB) show significantly increased levels of activity (P = .008). Exogenous TNF-α enhanced NF-κB nuclear translocation in MDS BMMCs above baseline levels. Treatment with arsenic trioxide (ATO; 2-200 μM) inhibited NF-κB activity in normal marrow, primary MDS, and ML1 cells, even in the presence of exogenous TNF-α (20 ng/mL), and down-regulated NF-κB-dependent antiapoptotic proteins, B-cell leukemia XL (Bcl-XL), Bcl-2, X-linked inhibitor of apoptosis (XIAP), and Fas-associated death domain (FADD)-like interleukin-1β-converting enzyme (FLICE) inhibitory protein (FLIP), leading to apoptosis. However, overexpression of FLIP resulted in increased NF-κB activity and rendered ML1 cells resistant to ATO-induced apoptosis. These data are consistent with the observed up-regulation of FLIP and resistance to apoptosis with advanced MDS, where ATO as a single agent may show only limited efficacy. However, the data also suggest that combinations of ATO with agents that interfere with other pathways, such as FLIP autoamplification via NF-κB, may have considerable therapeutic activity