123 research outputs found
Levetiracetam-induced pancytopenia.
Pancytopenia is a rare side effect of levetiracetam (LEV) that is associated with severe morbidity that requires hospitalization. Here, we report a patient with a right temporoparietal tumor who underwent a temporal craniotomy with resection of the mass and was started on LEV for seizure prophylaxis per the neurosurgery local protocol. The patient developed LEV-induced pancytopenia, which was successfully managed by discontinuation of this medication. Our report aims to increase awareness of this rare cause of pancytopenia among clinicians
A conjecture on Exceptional Orthogonal Polynomials
Exceptional orthogonal polynomial systems (X-OPS) arise as eigenfunctions of
Sturm-Liouville problems and generalize in this sense the classical families of
Hermite, Laguerre and Jacobi. They also generalize the family of CPRS
orthogonal polynomials. We formulate the following conjecture: every
exceptional orthogonal polynomial system is related to a classical system by a
Darboux-Crum transformation. We give a proof of this conjecture for codimension
2 exceptional orthogonal polynomials (X2-OPs). As a by-product of this
analysis, we prove a Bochner-type theorem classifying all possible X2-OPS. The
classification includes all cases known to date plus some new examples of
X2-Laguerre and X2-Jacobi polynomials
Local well-posedness for membranes in the light cone gauge
In this paper we consider the classical initial value problem for the bosonic
membrane in light cone gauge. A Hamiltonian reduction gives a system with one
constraint, the area preserving constraint. The Hamiltonian evolution equations
corresponding to this system, however, fail to be hyperbolic. Making use of the
area preserving constraint, an equivalent system of evolution equations is
found, which is hyperbolic and has a well-posed initial value problem. We are
thus able to solve the initial value problem for the Hamiltonian evolution
equations by means of this equivalent system. We furthermore obtain a blowup
criterion for the membrane evolution equations, and show, making use of the
constraint, that one may achieve improved regularity estimates.Comment: 29 page
On the vanishing electron-mass limit in plasma hydrodynamics in unbounded media
We consider the zero-electron-mass limit for the Navier-Stokes-Poisson system
in unbounded spatial domains. Assuming smallness of the viscosity coefficient
and ill-prepared initial data, we show that the asymptotic limit is represented
by the incompressible Navier-Stokes system, with a Brinkman damping, in the
case when viscosity is proportional to the electron-mass, and by the
incompressible Euler system provided the viscosity is dominated by the electron
mass. The proof is based on the RAGE theorem and dispersive estimates for
acoustic waves, and on the concept of suitable weak solutions for the
compressible Navier-Stokes system
The phosphorous necrosis of the jaws and what can we learn from the past: a comparison of "phossy" and "bisphossy" jaw
INTRODUCTION: The osteopathology of the jaws associated with bone resorption inhibitors is a current topic that engages a variety of clinical specialists. This has increased after the approval of denosumab for treatment of osteoporosis and skeletal-related events in patients with solid malignancy. Early after the first publications, there is a possible connection between phosphorous necrosis of the jaws, a dreadful industrial disease mentioned, and bisphosphonate-induced pathology. The nineteenth century was the prime time for phosphorus necrosis of match factory workers. RESULTS: This occurrence provides an interesting insight into the medical and surgical profession in the nineteenth century. There are striking parallels and repetition of current and old ideas in the approach to this "new disease." There are similar examples in case descriptions when compared with today's patients of bisphosphonate-related osteonecrosis of the jaws (BRONJ). DISCUSSION: Phosphorus necrosis was first described in Austria. Soon after this, surgeons in German-speaking countries including well-known clinicians Wegner (1872) and von Schulthess-Rechberg (1879) pioneered the analysis, preventative measures, and treatment of this disease. The tendency at this time was to approach BRONJ as a "special kind of osteomyelitis" in pretreated and metabolically different bone. Not only the treatment strategy to wait until sequestrum formation with subsequent removal and preventative measures but also the idea of focusing on the periosteum as the triggering anatomical structure may have been adopted from specialists in the nineteenth century. Therefore, phosphorous necrosis of the jaw is an excellent example of "learning from the past.
Evolution in the Brain, Evolution in the Mind: The Hierarchical Brain and the Interface between Psychoanalysis and Neuroscience
This article first aims to demonstrate the different ways the work of the English neurologist John Hughlings Jackson influenced Freud. It argues that these can be summarized in six points. It is further argued that the framework proposed by Jackson continued to be pursued by twentieth-century neuroscientists such as Papez, MacLean and Panksepp in terms of tripartite hierarchical evolutionary models. Finally, the account presented here aims to shed light on the analogies encountered by psychodynamically oriented neuroscientists, between contemporary accounts of the anatomy and physiology of the nervous system on the one hand, and Freudian models of the mind on the other. These parallels, I will suggest, are not coincidental. They have a historical underpinning, as both accounts most likely originate from a common source: John Hughlings Jackson's tripartite evolutionary hierarchical view of the brain
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