Evolution of suprathermal seed particle and solar energetic particle abundances

We report on a survey of the composition of solar-wind suprathermal tails and solar energetic particles (SEPs) including data from 1998 to 2010, with a focus on 2007 to 2010. The start of solar cycle 24 included several SEP events that were unusually He-poor. We conclude that these He-poor events are more likely related to Q/M-dependent spectral variations than to seed-particle composition changes. We also find that the quiet-time suprathermal Fe/O ratio during the 2008-2009 solar-minimum was dramatically lower (Fe/O ≤ 0.01) than earlier due in part to very low solar activity, but also suggesting contributions from an oxygen-rich source of suprathermal ions of unknown origin

Traditional and Complementary Medicine Use Among Indigenous Cancer Patients in Australia, Canada, New Zealand, and the United States: A Systematic Review

© The Author(s) 2018. Background: Cancer ‘patients’ are increasingly using traditional indigenous and complementary medicines (T&CM) alongside conventional medical treatments to both cure and cope with their cancer diagnoses. To date T&CM use among Indigenous cancer patients from Australia, Canada, New Zealand, and the United States has not been systematically reviewed. Methods: We systematically searched bibliographic databases to identify original research published between January 2000 and October 2017 regarding T&CM use by Indigenous cancer patients in Australia, Canada, New Zealand, and the United States. Data from records meeting eligibility criteria were extracted and appraised for quality by 2 independent reviewers. Results: Twenty-one journal articles from 18 studies across all 4 countries met our inclusion criteria. T&CM use ranged from 19% to 57.7% (differing across countries). T&CM was mostly used concurrently with conventional cancer treatments to meet their spiritual, emotional, social, and cultural needs; however, bush, traditional, and herbal medicines were used in a minority of cases as an alternative. Conclusions: Our findings highlight the importance of T&CM use to Indigenous cancer patients across these 4 countries; we identified multiple perceived spiritual, emotional and cultural benefits to its use. The patient’s perception of their health professional’s attitudes toward T&CM in some cases hindered or encouraged the patient’s disclosure. Additional research is required to further explore the use and disclosure of T&CM among Indigenous cancer patients to help inform and ensure effective, safe, coordinated care for Indigenous cancer patients that relies on shared open decision making and communication across patients, communities, and providers

Investigating the longitude dependence of solar energetic particle spectra

We examine the traits of six solar energetic particle events observed simultaneously by instruments on ACE and at least one of the twin STEREO spacecraft. We compare the time profiles and spectra of energetic oxygen as a function of the longitudinal separation of the observer from the solar source region. We find systematic trends in the rise and peak times with source longitude that are consistent with those determined from single spacecraft studies. However, we also find two events where the rise times were surprisingly rapid when the source region was over the western limb relative to the observer. This has potential consequences for space weather predictions of radiation hazards. No clear trend is apparent for hardness of the event-integrated spectra with source longitude contrary to trends seen in the single spacecraft studies

Cosmic ray neon, Wolf-Rayet stars, and the superbubble origin of galactic cosmic rays

The abundances of neon isotopes in the galactic cosmic rays (GCRs) are reported using data from the Cosmic Ray Isotope Spectrometer (CRIS) aboard the Advanced Composition Explorer (ACE). We compare our ACE-CRIS data for neon and refractory isotope ratios, and data from other experiments, with recent results from two-component Wolf-Rayet (WR) models. The three largest deviations of GCR isotope ratios from solar-system ratios predicted by these models are indeed present in the GCRs. Since WR stars are evolutionary products of OB stars, and most OB stars exist in OB associations that form superbubbles, the good agreement of these data with WR models suggests that superbubbles are the likely source of at least a substantial fraction of GCRs.Comment: 22 pages, 6 figures Accepted for publication by Ap

STEREO and ACE Observations of Energetic Particles from Corotating Interaction Regions

Since early 2007, significant particle enhancements due to corotating interaction regions (CIRs) have regularly appeared at 1 AU without any appreciable contamination from solar energetic particles (SEPs). In 2009 the prevalence of CIRs diminished as the maximum speed of the high speed solar wind streams in the ecliptic decreased along with the tilt of the heliospheric current sheet. Observations of CIR time profiles at different longitudes from STEREO show delays between the Behind and Ahead spacecraft that are often roughly as expected from the corotation time lag, although small differences in the spacecraft latitudes introduce significant scatter in the time delays. In some cases different features seen at Ahead and Behind suggest that transient disturbances in the solar wind may alter connection to or transport from the shock, or that temporal changes occur in the CIR shock itself. H and He data from STEREO/LET at 1.8–6 MeV/nucleon show that 1) the CIR spectral index at these energies is ~−4, independent of intensity but with considerable variability, 2) the He/H ratio is ~0.03 for larger CIRs but varies systematically with energy and event intensity, and 3) although the correlation between the CIR MeV particle increases and solar wind speed is generally good, many times a high-speed stream is not associated with MeV particles, while at other times a recurring series of CIR particle increases appears only at higher energies and may be associated with current sheet crossings and low speed solar wind

Hydrostatic pressure does not cause detectable changes to survival of human retinal ganglion

Purpose: Elevated intraocular pressure (IOP) is a major risk factor for glaucoma. One consequence of raised IOP is that ocular tissues are subjected to increased hydrostatic pressure (HP). The effect of raised HP on stress pathway signaling and retinal ganglion cell (RGC) survival in the human retina was investigated. Methods: A chamber was designed to expose cells to increased HP (constant and fluctuating). Accurate pressure control (10-100mmHg) was achieved using mass flow controllers. Human organotypic retinal cultures (HORCs) from donor eyes (<24h post mortem) were cultured in serum-free DMEM/HamF12. Increased HP was compared to simulated ischemia (oxygen glucose deprivation, OGD). Cell death and apoptosis were measured by LDH and TUNEL assays, RGC marker expression by qRT-PCR (THY-1) and RGC number by immunohistochemistry (NeuN). Activated p38 and JNK were detected by Western blot. Results: Exposure of HORCs to constant (60mmHg) or fluctuating (10-100mmHg; 1 cycle/min) pressure for 24 or 48h caused no loss of structural integrity, LDH release, decrease in RGC marker expression (THY-1) or loss of RGCs compared with controls. In addition, there was no increase in TUNEL-positive NeuN-labelled cells at either time-point indicating no increase in apoptosis of RGCs. OGD increased apoptosis, reduced RGC marker expression and RGC number and caused elevated LDH release at 24h. p38 and JNK phosphorylation remained unchanged in HORCs exposed to fluctuating pressure (10-100mmHg; 1 cycle/min) for 15, 30, 60 and 90min durations, whereas OGD (3h) increased activation of p38 and JNK, remaining elevated for 90min post-OGD. Conclusions: Directly applied HP had no detectable impact on RGC survival and stress-signalling in HORCs. Simulated ischemia, however, activated stress pathways and caused RGC death. These results show that direct HP does not cause degeneration of RGCs in the ex vivo human retina

Solar Energetic Particle Spectral Breaks

The five large solar particle events during October–November 2003 presented an opportunity to test shock acceleration models with in-situ observations. We use solar particle spectra of H to Fe ions, measured by instruments on ACE, SAMPEX, and GOES-11, to investigate the Q/M-dependence of spectral breaks in the 28 October 2003 event. We find that the break energies scale as (Q/M)^b with b ≈ 1.56 to 1.75, somewhat less than predicted. We also conclude that SEP spectra >100 MeV/nucleon are best fit by a double power-law shape. ©2005 American Institute of Physic

Isotopic Composition of Solar Wind Calcium: First in Situ Measurement by CELIAS/MTOF on Board SOHO

We present first results on the Ca isotopic abundances derived from the high resolution Mass Time-of-Flight (MTOF) spectrometer of the charge, element, and isotope analysis system (CELIAS) experiment on board the Solar and Heliospheric Observatory (SOHO). We obtain isotopic ratios 40Ca/42Ca = (128+-47) and 40Ca/44Ca = (50+-8), consistent with terrestrial values. This is the first in situ determination of the solar wind calcium isotopic composition and is important for studies of stellar modeling and solar system formation since the present-day solar Ca isotopic abundances are unchanged from their original isotopic composition in the solar nebula.Comment: 14 pages, 3 figure

Fe Enhancements in SEP Onsets: Flare/CME Mixture or Transport Effect?

During the onset phases of SEP events, the Fe/O ratio is often observed to be initially enhanced (˜1) over typical SEP values, followed by a decline to values close to typical averages over entire events (Fe/O ˜0.1). Two mechanisms have been suggested to explain this behavior, namely (1) a two-step process with an initial injection of “flare" particles with high Fe/O followed by shock-accelerated particles with lower Fe/O, and (2) a transport effect wherein the lower charge-to-mass ratio of Fe vs. O results in faster transport of Fe to the observer, leading to enhanced Fe/O in the early stages of the event. Distinguishing between these two scenarios is important to building a basic picture of processes taking place in large SEP events. We have carried out a detailed study of 17 large SEP events where energetic particle data were fitted by a state-of-the-art model whose computed time-intensity profiles were compared to the observed profiles of H, He, O, and Fe over a very broad energy range. We find that the observed decrease in Fe/O during the rise phase can be reasonably fitted by the transport model where the differences in Fe vs. O transport are due to the slope of the turbulence spectrum of the interplanetary magnetic field (IMF)