Morphology modulation of silica mesoporous nano- and microparticles for atrazine - controlled release

Atrazine is a moderately toxic triazine, used as a selective pre- and post-emergence herbicide. After application, it remains in the environment due to its low biodegradability causing severe environmental effects. Several controlled release systems have been proposed in order to minimize the negative impact of the herbicide on the environment. In particular, mesoporous silica nanoparticles have shown great potential in the agricultural area due to their controlled size and porosity, high surface area and non-toxicity. In this work, silica nano- and microparticles were synthesized and evaluated as atrazine delivery systems. The morphology and size distribution of the particles were characterized using dynamic light scattering (DLS) and scanning electron microscopy (SEM). The release profiles were studied by in vitro assays in water. In addition, phytotoxicity tests were performed using Lactuca sativa seeds. The mesoporous nano- and microparticles exhibited sustained release for at least 24 h and reduced phytotoxicity compared to free atrazine.Fil: Fookes, Federico Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Busatto, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Taverna, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Casis, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Lescano, Maia Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Estenoz, Diana Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentin

Study of advanced processes for the oxidation and removal of arsenic from water. Application of UV H2O2 system.

La contaminación con arsénico es un problema mundial. Debido a su toxicidad, se ha establecido una concentración máxima de 10 ppb para aguas de consumo. Las aguas subterráneas contienen las formas inorgánicas de As (III) (arsenito) y As (V) (arseniato). El arsenito es más tóxico y difícil de remover que el arseniato. Los procesos avanzados son más convenientes para la oxidación que los métodos tradicionales. El proceso UV H2O2 es eficiente y sencillo de implementar. Por otro lado, la adsorción es un proceso de remoción atractivo debido a su alta eficiencia y bajo costo. El objetivo de esta tesis es el estudio del proceso UV H2O2 combinado a una tecnología de adsorción para la remoción de arsénico en agua. Las experiencias de oxidación fueron llevadas a cabo en un pequeño reactor empleando diferentes condiciones operativas. Se desarrolló un esquema de reacción y se estimaron los parámetros cinéticos. Para el estudio del proceso de adsorción, se evaluaron tres materiales mediante ensayos batch y en columna. Este proceso fue modelado obteniéndose las isotermas y curvas de ruptura. Finalmente, se construyó un equipo que combina ambos procesos a mayor escala y las experiencias se llevaron a cabo bajo diferentes condiciones operativas. Puede concluirse que el proceso UV H2O2 es eficiente para la oxidación de arsénico(III) en agua. Además, la tecnología combinada es eficiente y prometedora para la remoción de arsénico a pequeña y mediana escala. Aplicando diferentes modelos para cada proceso, se logró diseñar un sistema combinado de remoción y predecir su desempeño.La contaminación con arsénico es un problema mundial. Debido a su toxicidad, se ha establecido una concentración máxima de 10 ppb para aguas de consumo. Las aguas subterráneas contienen las formas inorgánicas de As (III) (arsenito) y As (V) (arseniato). El arsenito es más tóxico y difícil de remover que el arseniato. Los procesos avanzados son más convenientes para la oxidación que los métodos tradicionales. El proceso UV H2O2 es eficiente y sencillo de implementar. Por otro lado, la adsorción es un proceso de remoción atractivo debido a su alta eficiencia y bajo costo. El objetivo de esta tesis es el estudio del proceso UV H2O2 combinado a una tecnología de adsorción para la remoción de arsénico en agua. Las experiencias de oxidación fueron llevadas a cabo en un pequeño reactor empleando diferentes condiciones operativas. Se desarrolló un esquema de reacción y se estimaron los parámetros cinéticos. Para el estudio del proceso de adsorción, se evaluaron tres materiales mediante ensayos batch y en columna. Este proceso fue modelado obteniéndose las isotermas y curvas de ruptura. Finalmente, se construyó un equipo que combina ambos procesos a mayor escala y las experiencias se llevaron a cabo bajo diferentes condiciones operativas. Puede concluirse que el proceso UV H2O2 es eficiente para la oxidación de arsénico(III) en agua. Además, la tecnología combinada es eficiente y prometedora para la remoción de arsénico a pequeña y mediana escala. Aplicando diferentes modelos para cada proceso, se logró diseñar un sistema combinado de remoción y predecir su desempeño.Consejo Nacional de Investigaciones Científicas y Técnicas Universidad Nacional del Litoral Agencia Nacional de Promoción Científica y Tecnológic

Milli-channel array for direct and quick reading of root elongation bioassays

A novel platform to perform systematic analysis and direct reading of root elongation bioassays is presented. The device was designed to include multiplexed microenvironments for the germination and growth of individual seeds, which allows observation by the naked eye or by optical systems, notably cellphone cameras. Prototypes were fabricated by laser micromachining on a highly transparent material that is fully compatible with biological systems. The effectiveness of the milli-channel array was verified against the conventional system (Petri dish). Lactuca sativa was chosen as a model species and glyphosate as a typical toxic agent. All tests were run according to standardized procedures and data analysis was carried out through different statistical indicators such as the root elongation and germination indexes. Results attained in the milli-channel array were identical to those in Petri dish, with the remarkable benefit that several steps required in the conventional system were avoided, which enormously decreases the operation time and the possibility of experimental errors. Further advantages of the milli-channel array are also reported, such as the capability to achieve live imaging of plant organs growth through a simple experiment. The developed device has been proven to be effective, versatile, easy-to-use, and integrable to cellphones, which naturally provide facilities for data recording, analysis, and networking. These improvements open the route to novel applications of bioassays in the wide field of ecotoxicology and environmental studies.Fil: Macagno, Joana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Lescano, Maia Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Berli, Claudio Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentin

Arsenic removal from water employing a combined system: photooxidation and adsorption

A combined system employing photochemical oxidation (UV/H2O2) and adsorption for arsenic removal from water was designed and evaluated. In this work, a bench-scale photochemical annular reactor was developed being connected alternately to a pair of adsorption columns filled with titanium dioxide (TiO2) and granular ferric hydroxide (GFH). The experiences were performed by varying the relation of As concentration (As (III)/As (V) weight ratio) at constant hydrogen peroxide concentration and incident radiation. Experimental oxidation results were compared with theoretical predictions using an intrinsic kinetic model previously obtained. In addition, the effectiveness of the process was evaluated using a groundwater sample. The mathematical model of the entire system was developed. It could be used as an effective tool for the design and prediction of the behaviour of these types of systems. The combined technology is efficient and promising for arsenic removal to small and medium scale.Fil: Lescano, Maia Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); ArgentinaFil: Zalazar, Cristina Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química (i); Argentina. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas; ArgentinaFil: Brandi, Rodolfo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentina. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas; Argentin

Advanced oxidation of commercial herbicides mixture: experimental design and phytotoxicity evaluation

In this work, the suitability of the UV/H2O2 process for commercial herbicides mixture degradation was studied. Glyphosate, the herbicide most widely used in the world, was mixed with other herbicides that have residual activity as 2,4-D and atrazine. Modeling of the process response related to specific operating conditions like initial pH and initial H2O2 to total organic carbon molar ratio was assessed by the response surface methodology (RSM). Results have shown that second-order polynomial regression model could well describe and predict the system behavior within the tested experimental region. It also correctly explained the variability in the experimental data. Experimental values were in good agreement with the modeled ones confirming the significance of the model and highlighting the success of RSM for UV/H2O2 process modeling. Phytotoxicity evolution throughout the photolytic degradation process was checked through germination tests indicating that the phytotoxicity of the herbicides mixture was significantly reduced after the treatment. The end point for the treatment at the operating conditions for maximum TOC conversion was also identified.Fil: López, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Coll, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Lescano, Maia Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Zalazar, Cristina Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentin

Biodegradation of pesticide-contaminated wastewaters from a formulation plant employing a pilot scale biobed

In this work, a pilot biobed was built up to treat pesticide-contaminated wastewaters discharged from a formulation plant. The pre-treated wastewater was spiked with additional pesticides in order to simulate a scenario of higher contamination: glyphosate, atrazine, imidacloprid, prometryn and carbendazim were added to reach a final Total Organic Carbon (TOC) concentration of 70 mg L−1. An Intermediate Bulk Container (IBC) was filled with a biomixture of soil and foxtail millet stubble (50:50% v v−1), and 200 l of the wastewater was added to the system recycling tank. The recirculation to the IBC was established for 12 h. After that (Day 0), the recirculation was turned on during the assay only to maintain the moisture for 180 days. Biomixture and wastewater samples were taken periodically to analyse pesticides and phytotoxicity in both matrices. In addition, hydrolytic and phenoloxidase activities, total bacteria and yeast and fungi communities were determined in the biomixture. The designed pilot scale biobed allowed to treat wastewaters with high concentration of pesticides reaching a complete removal of glyphosate, AMPA, atrazine, carbendazim and prometryn at 180 days. A good degradation percentage of the recalcitrant imidacloprid was achieved (60%) and the biomixture showed enough biological activity to continue treating additional wastewater. The root elongation index from the germination test showed low toxicity on day 180 both in biomixture and wastewater. The millet stubble resulted an appropriate lignocellulosic material to be used in biobeds to treat a wide variety of pesticides. The application of the seed germination test proved to be a low cost and simple tool to determine the end point of the process.Fil: Lescano, Maia Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Fussoni, N.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Vidal, Eduardo Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Zalazar, Cristina Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentin

Poultry litter stabilization by two-stage composting-vermicomposting process: Environmental, energetic and economic performance

Poultry litter (PL) is a heterogeneous mixture that contains bedding materials, antibiotics, dead skin, feed scraps, water, feathers and the resulting microbiota from poultry production cycle. Although its treatment does not receive attention, it is an important organic resource generated in the north-east region of Santa Fe Province since animal primary production is one of the main economic activities there and in the whole country. The objective of this work was to analyse the economic and energy aspects and the environmental impact of two scenarios corresponding to treat two different mixtures of organic wastes: Eucalyptus sp. sawdust (ES), rice hulls (RH) and PL. PL was considered in two different volume proportions: 1RH:3 PL for scenario 1 and 0.5RH:1 ES:2 PL for scenario 2. The two-stage combined system of composting + vermicomposting was applied to both scenarios and compared; on one hand, the current regulated practice for waste final deposition (landfill) and on the other hand, a base line scenario, which describes the current situation, where the raw material is transported and spread over the field as fertilizer without previous stabilization. The scenario construction was based according to on-site data, lab-scale experiments previously published and software databases. The environmental study was carried out with life cycle assessment; and the energy study, using cumulative energy demand methodology and the energy balance. Based on the results, it was possible to affirm the importance of the integrated agricultural waste treatment to address environmental benefits, especially related to the base line scenario. Furthermore, there were no significant differences between the two proposed scenarios. Economic and environmental results were contradictory when no long-term socio-economic consequences are considered. Combined composting and vermicomposting strategy reduce the organic matter and nutrients content not only to avoid discharges into the environment, but also to replace the fossil fuels consumption during unsustainable techniques as sanitary landfill, producing improved substrates for agricultural use.Fil: Vicentin, Rocio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Masin, Carolina Elisabet. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Lescano, Maia Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Zalazar, Cristina Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentin

Arsenic sorption onto titanium dioxide, granular ferric hydroxide and activated alumina: Batch and dynamic studies

The aim of this work was to evaluate and compare the efficiencies of three different adsorbents for arsenic (As) removal from water: titanium dioxide (TiO2), granular ferric hydroxide (GFH) and activated alumina (AA). Equilibrium experiments for dissolved arsenite and arsenate were carried out through batch tests. Freundlich and Langmuir isotherm models were adopted and their parameters were estimated by non-linear regressions. In addition, dynamic experiments were performed in mini fixed bed columns and breakthrough curves were obtained for each combination of sorbate/adsorbent. Experimental results obtained by column assays were compared with predictions of well-known breakthrough models (Bohart?Adams and Clark). Results indicate that As(V) is more easily adsorbed than As(III) for AA and GFH, while TiO2 has a similar behavior for both species. The titanium-based material is the most efficient adsorbent to carry out the process, followed by the GFH.Fil: Lescano, Maia Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); ArgentinaFil: Passalia, Claudio. Universidad Nacional del Litoral. Facultad de Ingeniería y Ciencias Hídricas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Zalazar, Cristina Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); ArgentinaFil: Brandi, Rodolfo Juan. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentin

Bioremediation of hydrocarbon contaminated soil using local organic materials and earthworms

Bioremediation technologies have demonstrated significant success on biological quality recovery of hydrocarbon contaminated soils, employing techniques among which composting and vermiremediation stand out. The aim of this study was to evaluate the efficiency of these processes to remediate diesel-contaminated soil, employing local organic materials and earthworms. During the initial composting stage (75 days), the substrate was made up using contaminated soil, lombricompost, rice hulls and wheat stubbles (60:20:15:5% w/w). Diesel concentration in the contaminated substrate was about 5 g kg−1, equivalent to a Total Petroleum Hidrocarbons (TPH) experimental concentration of 3425 ± 50 mg kg−1. During the later vermiremediation stage (60 days), the earthworm species Eisenia fetida and Amynthas morrisi were evaluated for their hydrocarbon degradation capacity. Physicochemical and biological assays were measured at different times of each stage and ecotoxicity assays were performed at the end of the experiments. TPH concentration reduced 10.91% after composting and from 45.2 to 60.81% in the different treatments after vermiremediation. Compared with TPH degradation in the treatment without earthworms (16.05%), results indicate that earthworms, along with indigenous microorganisms, accelerate the remediation process. Vermiremediation treatments did not present phytotoxicity and reflected high substrate maturity values (>80% Germination Index) although toxic effects were observed due to E. fetida and A morrisi exposure to diesel. Vermiremediation was an efficient technology for the recovery of substrate biological quality after diesel contamination in a short period. The addition of organic materials and suitable food sources aided earthworm subsistence, promoted the decontamination process and improved the substrate quality for future productive applications.Fil: Nobli, Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Masin, Carolina Elisabet. Universidad Católica de Santa Fe; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Zalazar, Cristina Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Lescano, Maia Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentin

Degradation of chlorpyrifos formulation in water by the UV/H2O2 process: Lumped kinetic modelling of total organic carbon removal

The degradation of a commercial chlorpyrifos (CP) formulation solution under the UV/H2O2 process was predicted through a lumped kinetics modelling approach (LKA). The proposed models are based on different reaction schemes that include the hydroxyl radical reaction rate with the Total Organic Carbon (TOC). TOC represents the concentration of the mixture of CP and “unknown organic matter”, both components present in CP formulation. TOC is one of the most practical parameter that can be used to quantify organic pollution in a complex matrix. A one-step model was selected and a second-order reaction rate constant between hydroxyl radical and TOC was obtained by optimization: 1.75 × 107 M−1 s−1. According to computed performance metrics, the chosen model well fitted the concentrations evolution of the reactants (TOC and H2O2). The model could be useful to predict the behaviour of reaction systems with different configuration for wastewater treatment applications.Fil: Lescano, Maia Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: López, Alejandro Omar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Romero, Roberto Leopoldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Zalazar, Cristina Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentin