Complex Radio Spectral Energy Distributions in Luminous and Ultraluminous Infrared Galaxies

We use the Expanded Very Large Array to image radio continuum emission from local luminous and ultraluminous infrared galaxies (LIRGs and ULIRGs) in 1 GHz windows centered at 4.7, 7.2, 29, and 36 GHz. This allows us to probe the integrated radio spectral energy distribution (SED) of the most energetic galaxies in the local universe. The 4-8 GHz flux densities agree well with previous measurements. They yield spectral indices \alpha \approx -0.67 (where F_\nu \propto \nu^\alpha) with \pm 0.15 (1\sigma) scatter, typical of nonthermal (synchrotron) emission from star-forming galaxies. The contrast of our 4-8 GHz data with literature 1.5 and 8.4 GHz flux densities gives further evidence for curvature of the radio SED of U/LIRGs. The SED appears flatter near \sim 1 GHz than near \sim 6 GHz, suggesting significant optical depth effects at the lower frequencies. The high frequency (28-37 GHz) flux densities are low compared to extrapolations from the 4-8 GHz data. We confirm and extend to higher frequency a previously observed deficit of high frequency radio emission for luminous starburst galaxies.Comment: 7 pages, 3 figures, 1 table, accepted for publication in the EVLA Special Issue of ApJ Letter

Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes

Obesity and high saturated fat intake increase the risk of heart failure and arrhythmias. The molecular mechanisms are poorly understood. We hypothesized that physiologic levels of saturated fat could increase mitochondrial reactive oxygen species (ROS) in cardiomyocytes, leading to abnormalities of calcium homeostasis and mitochondrial function. We investigated the effect of saturated fat on mitochondrial function and calcium homeostasis in isolated ventricular myocytes. The saturated fatty acid palmitate causes a decrease in mitochondrial respiration in cardiomyocytes. Palmitate, but not the monounsaturated fatty acid oleate, causes an increase in both total cellular ROS and mitochondrial ROS. Palmitate depolarizes the mitochondrial inner membrane and causes mitochondrial calcium overload by increasing sarcoplasmic reticulum calcium leak. Inhibitors of PKC or NOX2 prevent mitochondrial dysfunction and the increase in ROS, demonstrating that PKC-NOX2 activation is also required for amplification of palmitate induced-ROS. Cardiomyocytes from mice with genetic deletion of NOX2 do not have palmitate-induced ROS or mitochondrial dysfunction. We conclude that palmitate induces mitochondrial ROS that is amplified by NOX2, causing greater mitochondrial ROS generation and partial depolarization of the mitochondrial inner membrane. The abnormal sarcoplasmic reticulum calcium leak caused by palmitate could promote arrhythmia and heart failure. NOX2 inhibition is a potential therapy for heart disease caused by diabetes or obesity

Discovery and Prevalence of Divergent RNA Viruses in European Field Voles and Rabbits

The advent of unbiased metagenomic virus discovery has revolutionized studies of virus biodiversity and evolution. Despite this, our knowledge of the virosphere, including in mammalian species, remains limited. We used unbiased metagenomic sequencing to identify RNA viruses in European field voles and rabbits. Accordingly, we identified a number of novel RNA viruses including astrovirus, rotavirus A, picorna-like virus and a morbilli-like paramyxovirus. In addition, we identified a sobemovirus and a novel luteovirus that likely originated from the rabbit diet. These newly discovered viruses were often divergent from those previously described. The novel astrovirus was most closely related to a virus sampled from the rodent-eating European roller bird (Coracias garrulous). PCR screening revealed that the novel morbilli-like paramyxovirus in the UK field vole had a prevalence of approximately 4%, and shared common ancestry with other rodent morbilli-like viruses sampled globally. Two novel rotavirus A sequences were detected in a UK field vole and a French rabbit, the latter with a prevalence of 5%. Finally, a highly divergent picorna-like virus found in the gut of the French rabbit virus was only ~35% similar to an arilivirus at the amino acid level, suggesting the presence of a novel viral genus within the Picornaviridae

Key Science Goals for the Next Generation Very Large Array (ngVLA): Report from the ngVLA Science Advisory Council

This document describes some of the fundamental astrophysical problems that require observing capabilities at millimeter- and centimeter wavelengths well beyond those of existing, or already planned, telescopes. The results summarized in this report follow a solicitation from the National Radio Astronomy Observatory to develop key science cases for a future U. S.-led radio telescope, the "next generation Very Large Array" (ngVLA). The ngVLA will have roughly 10 times the collecting area of the Jansky VLA, operate at frequencies from 1 GHz to 116 GHz with up to 20 GHz of bandwidth, possess a compact core for high surface-brightness sensitivity, and extended baselines of at least hundreds of kilometers and ultimately across the continent to provide high-resolution imaging. The ngVLA builds on the scientific and technical legacy of the Jansky VLA and ALMA, and will be designed to provide the next leap forward in our understanding of planets, galaxies, and black holes.Comment: ngVLA memo 1

First Views of a Nearby LIRG: Star Formation and Molecular Gas in IRAS 04296+2923

We present a first look at the local LIRG, IRAS04296+2923. This barred spiral, overlooked because of its location in the Galactic plane, is among the half dozen closest LIRGs. More IR-luminous than either M82 or the Antennae, it may be the best local example of a nuclear starburst caused by bar-mediated secular evolution. We present Palomar J and Pa beta images, VLA maps from 20-1.3cm, a Keck LWS image at 11.7mic and OVRO CO(1-0) and ^13CO(1-0), and 2.7 mm continuum images. The J-band image shows a symmetric barred spiral. Two bright, compact mid-IR/radio sources in the nucleus comprise a starburst that is equivalent to 10^5 O7 stars, probably a pair of young super star clusters separated by 30pc. The nuclear starburst is forming stars at the rate of ~12Msun/yr, half of the total star formation rate for the galaxy of ~25Msun/yr. IRAS04296 is bright in CO, and among the most gas-rich galaxies in the local universe. The CO luminosity of the inner half kpc is equivalent to that of the entire Milky Way. While the most intense CO emission extends over a 15"(2 kpc) region, the nuclear starburst is confined to ~1-2"(150-250 pc) of the dynamical center. From ^13CO, we find that the CO conversion factor in the nucleus is higher than the Galactic value by a factor 3-4, typical of gas-rich spiral nuclei. The nuclear star formation efficiency is M_gas/SFR^nuc = 2.7x10^-8 yr^-1, corresponding to gas consumption timescale, tau_SF^nuc~4x10^7 yrs. The star formation efficiency is ten times lower in the disk, tau_SF^disk~3.3x10^8 yrs. The low absolute star formation efficiency in the disk implies that the molecular gas is not completely consumed before it drifts into the nucleus, and is capable of fueling a sustained nuclear starburst. IRAS04296 is beginning a 100Myr period as a LIRG, during which it will turn much of its 6x10^9Msun of molecular gas into a nuclear cluster of stars. (abridged)Comment: Accepted, Astronomical Journa