N-(2,4-Dinitro­phen­yl)dehydro­abietyl­amine

In the crystal structure of the title compound, C26H33N3O4, there are two crystallographically independent mol­ecules. The two cyclohexane rings are trans-fused; the ring neighboring the phenyl group is in a half-chair conformation and the other is in a chair conformation. The two nitro groups and the benzene ring of the dinitro­phenyl group are almost coplanar. Intra­molecular N—H⋯O hydrogen bonds and weak inter­molecular C—H⋯O hydrogen bonds are observed

ftp ejde.math.txstate.edu ANTI-PERIODIC SOLUTIONS FOR HIGH-ORDER CELLULAR NEURAL NETWORKS WITH TIME-VARYING DELAYS

Abstract. In this article, we study anti-periodic solutions for high-order cellular neural networks with time-varying delays. Sufficient conditions for the existence and exponential stability of anti-periodic solutions are presented. 1

The efficacy and safety of pharmacologic thromboprophylaxis following caesarean section: A systematic review and meta-analysis.

ObjectiveOur purpose is to evaluate the efficacy and safety of pharmacologic thromboprophylaxis following caesarean section (CS).MethodsWe searched PubMed, Embase, and the Cochrane Library. Then the systematic review was performed by analysing studies that met the eligibility criteria.ResultsSeven studies with 1243 participants were included, including 6 RCTs and 1 prospective cohort. Results from the meta-analysis showed that low molecular weight heparin (LMWH) was associated with no obvious decrease in the risk of thrombus compared with UHF and negative control. However, LMWH was observed to be associated with a definite increase in the risk of bleeding or haematomas in comparison to negative control (RR: 8.47, CI: 1.52-47.11).ConclusionAccording to current evidences, the efficacy of pharmacologic thromboprophylaxis which increases the risk of bleeding or hematomas remains controversial

N-Acetyl Cysteine Depletes Reactive Oxygen Species and Prevents Dental Monomer-Induced Intrinsic Mitochondrial Apoptosis In Vitro in Human Dental Pulp Cells.

To investigate the involvement of intrinsic mitochondrial apoptosis in dental monomer-induced cytotoxicity and the influences of N-acetyl cysteine (NAC) on this process.Human dental pulp cells (hDPCs) were exposed to several dental monomers in the absence or presence of NAC, and cell viability, intracellular redox balance, morphology and function of mitochondria and key indicators of intrinsic mitochondrial apoptosis were evaluated using various commercial kits.Dental monomers exerted dose-dependent cytotoxic effects on hDPCs. Concomitant to the over-production of reactive oxygen species (ROS) and depletion of glutathione (GSH), differential changes in activities of superoxide dismutase, glutathione peroxidase, and catalase were detected. Apoptosis, as indicated by positive Annexin V/propidium iodide (PI) staining and activation of caspase-3, was observed after dental monomer treatment. Dental monomers impaired the morphology and function of mitochondria, and induced intrinsic mitochondrial apoptosis in hDPCs via up-regulation of p53, Bax and cleaved caspase-3, and down-regulation of Bcl-2. NAC restored cell viability, relieved oxidative stress and blocked the apoptotic effects of dental monomers.Dental monomers induced oxidative stress and mitochondrial intrinsic apoptosis in hDPCs. NAC could reduce the oxidative stress and thus protect hDPCs against dental monomer-induced apoptosis