POTENSI SOVATELTIDE (IRL-1620) SEBAGAI OBAT NEUROPROTEKTIF MUTAKHIR STROKE ISKEMIK

Stroke adalah penyebab kematian tertinggi kedua di dunia. Stroke iskemik terjadi pada 88% kasus stroke, sedangkan stroke pendarahan terjadi pada 12% kasus. Baik pada dewasa maupun anak-anak, stroke dapat menyebabkan kecacatan sehingga memengaruhi produktivitas penderita. Namun, pengobatan stroke iskemik secara farmakologis merupakan tantangan bagi dunia kedokteran karena patologi stroke iskemik yang kompleks. Sebagai intervensi mutakhir, Sovateltide (IRL-1620/PMZ-1620) hadir sebagai agonis endothelin B receptors (ETBR) selektif yang prospektif dengan memberikan efek neuroprotektif dan angiogenesis pada stroke iskemik. Meskipun masih dalam uji coba klinis, belum ada studi pustaka yang membahas mengenai potensi Sovateltide sebagai neuroprotektif stroke iskemik. Sebagai solusinya, studi pustaka ini bertujuan untuk mengetahui potensi Sovateltide sebagai obat neuroprotektif mutakhir stroke iskemik. Studi pustaka secara sistematis ini merupakan hasil analisis dan sintesis dari berbagai referensi yang relevan dengan topik di Pubmed dan Google Scholar, dicari menggunakan berbagai kata kunci, dan jangka waktu tidak lebih dari 10 tahun. Sovateltide merupakan agonis ETBR yang paling selektif sehingga mampu memberikan efek neuroprotektif dengan meningkatkan proliferasi, survival rate, diferensiasi, neurogenesis, fusion mitokondria, dan perkembangan sel saraf. Selain itu, Sovateltide juga mampu meningkatkan Vascular Endothelial Growth Factor (VEGF) sehingga menyebabkan angiogenesis pada pembuluh darah otak yang mengalami oklusi. Berdasarkan penelitian, pemberian Sovateltide pada sampel tikus dewasa dan anak- anak dengan middle cerebral arteries occlusion (MCAO) berpotensi menjadi obat neuroprotektif stroke iskemik fase akut dan subakut. Sovateltide memiliki potensi yang baik sebagai obat neuroprotektif mutakhir stroke iskemik.

Knowledge, Attitude, and Practice of Undergraduate Medical Students in Indonesia on the COVID-19 Prevention

Background: Coronavirus Disease 2019 (COVID-19) caused a global pandemic since March 2020. Undergraduate medical students, who would later be referred to as students, were encouraged to educate Indonesian society about COVID-19. This study aimed to evaluate the knowledge, attitude, and practice of Indonesian students on COVID-19 prevention. Methods: An online cross-sectional study was conducted between August 22 and September 2, 2020, with a minimum sample size of 1068 subjects. The questionnaire was sent to 86 Faculty of Medicine (FoM) in Indonesia. The questionnaire consisted of knowledge, attitude, and practice section, with a total score, 15, 60, and 45, respectively. Scores above median were considered as sufficient knowledge, and positive attitude, and positive practice. Association between knowledge, attitude, and practice with gender, year of study, location of FoM, and source of information were tested using Chi-Square Test. Correlation among knowledge, attitude, and practice scores was tested using Spearman Rank Test. Results: Among 1390 participated students, 51.4%, 55.7%, and 56.3% had sufficient knowledge, positive attitude, and, positive practice, respectively. There were associations between knowledge and gender, year of study, location of FoM, and source of information (p<0.05), between attitude and gender, year of study, and source of information (p<0.05), and between practice and gender and source of information (p<0.05). There were weak correlations between knowledge with attitude (r=0.246, p<0.001) and between attitude and practice (r=0.272, p<0.001). Conclusions: Half of medical students in Indonesia showed sufficient knowledge, positive attitude, and positive practice on COVID-19 prevention. Hence, improvement towards COVID-19 prevention is required