Effects of High Glucose Concentrations on the Endothelial Function of the Renal Microcirculation of Rabbits

Submitted by Sandra Infurna ([email protected]) on 2019-06-18T13:13:29Z No. of bitstreams: 1 EduardoTibirca_FilipeSAfonso_etal_IOC_2003.pdf: 54454 bytes, checksum: 8fac63506f2c3be7ad182cfd91c1dae7 (MD5)Approved for entry into archive by Sandra Infurna ([email protected]) on 2019-06-18T13:24:49Z (GMT) No. of bitstreams: 1 EduardoTibirca_FilipeSAfonso_etal_IOC_2003.pdf: 54454 bytes, checksum: 8fac63506f2c3be7ad182cfd91c1dae7 (MD5)Made available in DSpace on 2019-06-18T13:24:50Z (GMT). No. of bitstreams: 1 EduardoTibirca_FilipeSAfonso_etal_IOC_2003.pdf: 54454 bytes, checksum: 8fac63506f2c3be7ad182cfd91c1dae7 (MD5) Previous issue date: 2003Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Laboratório de Farmacologia Neuro-Cardiovascular. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Laboratório de Farmacologia Neuro-Cardiovascular. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Laboratório de Farmacologia Neuro-Cardiovascular. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Laboratório de Farmacologia Neuro-Cardiovascular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Farmacologia Neuro Cardiovascular. Rio de Janeiro, RJ. Brasil.Objective – To assess the acute effects of high glucose concentrations on vascular reactivity in the isolated non diabetic rabbit kidney. Methods – Rabbits were anaesthetized for isolation of the kidneys. Renal arteries and veins were cannulated for perfusion with Krebs-Henselleit solution and measurement of perfusion pressure. After 3 hours of perfusion with glucose 5,5 mM (control ) and 15 mM, the circulation was submitted to sub maximal precontraction (80% of maximal response) trough continuous infusion of noradrenaline 10 mM. Vascular reactivity was then assessed trough dose–responses curves with endothelium-dependent (acetylcholine) and independent (sodium nitroprusside) vasodilators. The influence of hyperosmolarity was analyzed with perfusion with mannitol 15mM. Results – A significant reduction in the endotheliumdependent vasodilation in glucose 15mM group was observed compared to that in control, but there was no difference in endothelium-independent vasodilation. After perfusion with mannitol 15 mM, a less expressive reduction in endothelium-dependent vasodilation was observed, only reaching significance in regard to the greatest dose of acetylcholine. Conclusions – High levels of glucose similar to those found in diabetic patients in the postprandial period can cause significant acute changes in renal vascular reactivity rabbits. In diabetic patients these effects may also occur and contribute to diabetes vascular disease

Cannabinoids as a yield modifier in physical activit: A systematic review characters

Marijuana is considered illicit in much of the world, and is classified as a drug for recreational use, in recent decades the medicinal use of Cannabis sativa L. has grown and diversified, being considered the only therapeutic alternative in the control of serious and incurable diseases such as syndrome of Dravet. The world panorama has shown a more liberal position, since in several countries such as the United States of America, Holland, Australia, Italy, and more recently in Canada, the use of medications, or even the recreational use of this plant, have been regulated. In this context, the investigation of the modifying effects on physical activity of empirically used cannabinoids is fundamental nowadays, mainly due to the regulatory recognition of Cannabis sativa L. as a medicinal plant in a large part of the world. Therefore, the objective of this review was to verify the evidence related to the effect of cannabis on physical performance and to identify and highlight the challenges in the interpretation of information regarding the performance of practitioners of physical activity, as well as athletes, presenting new trends in this area of research to be addressed. To carry out the systematic review, a bibliographic survey of case reports was obtained through Pubmed, Science Direct and Google Academic databases. The following keywords were used to perform the research: cannabis, performance, pain, competition. The following filters were used as inclusion criteria a languages used english; species: humans; types of articles: original articles and reviews and period of publication of articles: 1981 to 2021