3D rendering (image threshold at p<0.05 FWE corrected) of the BOLD response of the main effects of group factor.

<p>Significant activation: INWARD: left posterior insula BA13, and the right parietal lobe SII BA40; OUTWARD: bilateral DLPFC BA9, bilateral precuneus BA7. 2-D overlay with multiple slices of insular activation in each group.</p

Inter-group comparisons p<0.001 uncorrected, k = 8.

<p>°p<0.01 uncorrected, k = 8.</p

Questionnaire Scores for Phobic prone and Eating disorders prone Groups.

<p>Underlined rows report significant differences between the PP and EDP groups. SD = standard deviation.</p

Main effects of pain and familiarity factors p<0.001 uncorrected, k = 8.

<p>°same cluster.</p

Left insula with significantly greater activation in the inward group, obtained with the the 3-way interaction analyses, identified at p<0.001 uncorrected, Ke = 8 voxels.

<p><b>a</b>) the left posterior insula (peak coordinates x = −41, y = −4, z = 10; p<0.01 uncorrected, Ke = 8 voxels); <b>b</b>) the left precuneus (peak coordinates x = −26, y = −71, z = 35); <b>c</b>) the right medial PFC (peak coordinates x = 11, y = 60, z = −5). PPF (partner's painful faces), PNF (partner's neutral faces), UPF (unfamiliar painful faces), UNF (unfamiliar neutral faces). Bars depict variance loadings and 90% confidence intervals.</p

Auto-regulation of Th1 responses through carboxypeptidase M-generated C5a-desArg

<p>Rendered image of the brain depicting the dorsolateral prefrontal clusters whose activity correlated positively with apathy scores during (a) working memory and (b) attentional control tasks. See the text for statistics.</p

Demographic data and Apathy Scale (AS) data for the whole sample (All) and for the subsamples performing the working memory (N-Back) and attentional control (VAC) tasks.

<p>Demographic data and Apathy Scale (AS) data for the whole sample (All) and for the subsamples performing the working memory (N-Back) and attentional control (VAC) tasks.</p

Behavioral data for the subsamples performing the working memory (N-Back) and attentional control (VAC) tasks.

<p>Behavioral data for the subsamples performing the working memory (N-Back) and attentional control (VAC) tasks.</p

Correlation between BOLD fMRI in prefrontal cortex and Working Memory accuracy in <i>CHRNA5</i>-GA/<i>DRD2</i>-GT subjects.

<p>3Dimensional rendering (left, image thresholded at p<0.005, uncorrected) of the correlation between BOLD response in DLPFC and percentage of correct responses at 2-Back task in <i>CHRNA5</i>-GA/<i>DRD2</i>-GT subjects. On the right, relative scatterplot is shown indicating individual data points.</p

Interaction between <i>DRD2</i> rs1076560 and <i>CHNRA5</i> rs16969968 on prefrontal gray matter volume.

<p>3Dimensional rendering (left, image thresholded at p<0.005, uncorrected) and mean ±0.95 CIs of gray matter content (right) of the interaction between <i>DRD2</i> rs1076560 and <i>CHNRA5</i> rs16969968 on DLPFC gray matter.</p