The Quest for Bandwidth Estimation Techniques for large-scale Distributed Systems

In recent years the research community has developed many techniques to estimate the end-to-end available bandwidth of an Internet path. This important metric has been proposed for use in several distributed systems and, more recently, has even been considered to improve the congestion control mechanism of TCP. Thus, it has been suggested that some existing estimation techniques could be used for this purpose. However, existing tools were not designed for large-scale deployments and were mostly validated in controlled settings, considering only one measurement running at a time. In this paper, we argue that current tools, while offering good estimates when used alone, might not work in large-scale systems where several estimations severely interfere with each other. We analyze the properties of the measurement paradigms employed today and discuss their functioning, study their overhead and analyze their interference. Our testbed results show that current techniques are insufficient as they are. Finally, we will discuss and propose some principles that should be taken into account for including available bandwidth measurements in large-scale distributed systems. 1

Did Going North Give Us Migraine? An Evolutionary Approach on Understanding Latitudinal Differences in Migraine Epidemiology

This commentary discusses a recent publication by evolutionary biologists with strong implications for migraine experts. The Authors showed that a gene polymorphism associated with migraine gave our ancestors an evolutionary advantage when colonizing northern, and thus colder, territories. They then highlight that the prevalence of migraine may differ among countries because of climatic adaptation. These results may prove useful in planning both epidemiological and physiological studies in the field of migraine

Intergenerational persistence in educational attainment in Italy

In this paper we show that there is a reduction in the correlation coefficient between father and children schooling levels over time in Italy. However, focusing on equality of circumstances, we show that there is still a persistent difference in the odds of attaining a college degree between children of college educated parents and children of parents with lower secondary education attainment. The explanation of these trends lies in differential impact of liquidity constraints and risk aversion. Some descriptive evidence on the persistent differential in returns to college education depending on father's education is also provided

A unified approach to the performance analysis of caching systems

We propose a unified methodology to analyse the performance of caches (both isolated and interconnected), by extending and generalizing a decoupling technique originally known as Che's approximation, which provides very accurate results at low computational cost. We consider several caching policies, taking into account the effects of temporal locality. In the case of interconnected caches, our approach allows us to do better than the Poisson approximation commonly adopted in prior work. Our results, validated against simulations and trace-driven experiments, provide interesting insights into the performance of caching systems

How much can large-scale video-on-demand benefit from users' cooperation?

We propose an analytical framework to tightly characterize the scaling laws for the additional bandwidth that servers must supply to guarantee perfect service in peer-assisted Video-on-Demand systems, taking into account essential aspects such as peer churn, bandwidth heterogeneity, and Zipf-like video popularity. Our results reveal that the catalog size and the content popularity distribution have a huge effect on the system performance. We show that users' cooperation can effectively reduce the servers' burden for a wide range of system parameters, confirming to be an attractive solution to limit the costs incurred by content providers as the system scales to large populations of user

LocaRDS: A Localization Reference Data Set

The use of wireless signals for the purposes of localization enables a host of applications relating to the determination and verification of the positions of network participants ranging from radar to satellite navigation. Consequently, this has been a longstanding interest of theoretical and practical research in mobile networks and many solutions have been proposed in the scientific literature. However, it is hard to assess the performance of these in the real world and, more importantly, to compare their advantages and disadvantages in a controlled scientific manner. With this work, we attempt to improve the current state of art methodology in localization research and to place it on a solid scientific grounding for future investigations. Concretely, we developed LocaRDS, an open reference data set of real-world crowdsourced flight data featuring more than 222 million measurements from over 50 million transmissions recorded by 323 sensors. We demonstrate how we can verify the quality of LocaRDS measurements so that it can be used to test, analyze and directly compare different localization methods. Finally, we provide an example implementation for the aircraft localization problem and a discussion of possible metrics for use with LocaRDS

Chemotherapy accelerates immune-senescence and functional impairments of Vδ2pos T cells in elderly patients affected by liver metastatic colorectal cancer.

Human (gamma delta) γδ T cells are unconventional innate-like lymphocytes displaying a broad array of anti-tumor activities with promising perspectives in cancer immunotherapy. In this context, Vδ2pos T cells represent the preferential target of several immunotherapy protocols against solid tumors. However, the impact of both aging and chemotherapy (CHT) on Vδ2pos T cells is still unknown. The present study evaluates with multi-parametric flow cytometry the frequencies, terminal differentiation, senescence and effector-functions of peripheral blood and tumor infiltrating Vδ2pos T cells purified from liver metastases (CLM) of patients affected by colorectal cancer (CRC) compared to those of sex- and age-matched healthy donors. The peripheral blood of CLM patients underwent CHT is characterized by decreased amounts of Vδ2pos T cells showing a relative increase of terminally-differentiated CD27neg/CD45RApos (TEMRA) cells. The enrichment of this latter subset is associated with an increased expression of the senescent marker CD57. The acquisition of CD57 on TEMRA Vδ2pos T cells is also coupled with impairments in cytotoxicity and production of TNF-α and IFN-γ. These features resemble the acquisition of an immune-senescent profile by Vδ2pos T cells from CLM patients that received CHT, a phenomenon that is also associated with the loss of the co-stimulatory marker CD28 and with the induced expression of CD16. The group of CLM patients underwent CHT and older than 60 years old showed higher frequencies of CD57pos and TEMRA Vδ2pos T cells. Similar results were found for tumor infiltrating Vδ2pos T cell subset purified from CLM specimens of patients treated with CHT. The toxicity of CHT regimens also affects the homeostasis of Vδ2pos T cells by inducing higher frequencies of circulating CD57pos TEMRA subset in CLM underwent CHT and younger than 60 years old. Taken together, our data demonstrate that the enrichment of senescent Vδ2pos T cells in CLM patients is not only induced by patients' aging but also by the toxicity of CHT that further accelerates the accumulation of CD57pos TEMRA cells highly dysfunctional in their anti-tumor activities. These results are important to both predict the clinical outcome of CLM and to optimize those protocols of cell cancer immunotherapy employing unconventional Vδ2pos T cells