3 research outputs found
Phe-MetNH<sub>2</sub> Terminal Bombesin Subfamily Peptides: Potential Induced Changes in Adsorption on Ag, Au, and Cu Electrodes Monitored by SERS
Surface-enhanced Raman scattering, electrochemistry,
and generalized
two-dimensional correlation analysis methods were used to characterize
phyllolitorin and a peptide derived from <i>Pseudophryne guntheri</i> (PG-L). Phyllolitorin and PG-L were deposited onto Ag, Au, and Cu
electrode surfaces at different applied electrode potentials in an
aqueous solution at physiological pH, and the orientations and adsorption
mechanisms of peptides were determined based on the enhancement, broadening,
and shifts in the wavenumbers of specific bands. On the basis of these
analyses, specific conclusions were drawn regarding the peptide geometry
and changes in the geometry that occurred when the electrode type
and applied electrode potential were varied. The phyllolitorin and
PG-L deposited onto the Ag, Au, and Cu electrode surfaces showed bands
that were due to the vibrations of moieties in contact with or in
close proximity to the electrode surfaces and were thus located on
the same side of the polypeptide backbone. These moieties included
the Phe and Trp rings, the sulfur atom of Met, and the amide bond.
Variations in the arrangement of these fragments were observed with
changes in the metal surface and the applied electrode potential
Vibrational and Theoretical Studies of the Structure and Adsorption Mode of <i>m</i>‑Nitrophenyl α‑Guanidinomethylphosphonic Acid Analogues on Silver Surfaces
This
work presents Fourier transform Raman (FT-Raman), Fourier transform
absorption infrared (FT-IR), and surface-enhanced Raman scattering
(SERS) spectroscopic investigations of three <i>m</i>-nitrophenyl
α-guanidinomethylphonic acids, including <i>m</i>-NO<sub>2</sub>PhG(cHex)P, <i>m</i>-NO<sub>2</sub>PhG(Morf)P, and <i>m</i>-NO<sub>2</sub>PhG(An)P, adsorbed onto colloidal and roughened
silver surfaces. The SERS spectra were deconvoluted to determine the
overlapped bands from which the specific molecular orientation can
be deducted. The vibrational wavenumbers are calculated through density
functional theory (DFT) at the B3LYP/6-31++G** level with the Gaussian
03, Raint, GaussSum 0.8, and GAR2PED software packages. The experimental
and calculated vibrational bands are compared to those from SERS for
the investigated compounds adsorbed on colloidal and roughened silver
surfaces. The geometry of these molecules on the SERS-active silver
surfaces is deduced from the observed changes in both the intensity
and width of the Raman bands in the spectra of the bound species relative
to the free species
Raman, Surface-Enhanced Raman, and Density Functional Theory Characterization of (Diphenylphosphoryl)(pyridin-2‑, -3‑, and -4-yl)methanol
This work presents near-infrared
Raman spectroscopy (FT-RS) and
surface-enhanced Raman scattering (SERS) studies of three pyridine-α-hydroxymethyl
biphenyl phosphine oxide isomers: (diphenylphosphoryl)(pyridin-2-yl)methanol
(α-Py), (diphenylphosphoryl)(pyridin-3-yl)methanol (β-Py),
and (diphenylphosphoryl)(pyridin-4-yl)methanol (γ-Py) adsorbed
onto colloidal and roughened in oxidation–reduction cycles
silver surfaces. The molecular geometries in the equilibrium state
and vibrational frequencies were calculated by density functional
theory (DFT) at the B3LYP 6-311G(df,p) level of theory. The results
imply that the most stable structure of the investigated molecules
is a dimer created by two intermolecular hydrogen bonds between the
H atom of the α-hydroxyl group (in up (HO<sub>U</sub>) or down
(HO<sub>D</sub>) stereo bonds position) and the O atom of tertiary
phosphine oxide (O) of the two monomers. Comparison the FT-RS
spectra with the respective SERS spectra allowed us to predict the
orientation of the hydroxyphosphonate derivatives of pyridine that
depends upon both the position of the substituent relative to the
ring N atom (in α-, β-, and γ-position, respectively)
and the type of silver substrate