55 research outputs found
Studio paleopatologico delle mummie naturali di Goriano Valli (L'Aquila). Risultati preliminari.
Solitary fibrous tumor of the oral cavity with a predominant leiomyomatous like pattern: a potential diagnostic pitfall
The diagnosis of solitary fibrous tumor (SFT) is usually straightforward if the typical morphologic
features, including a wide variety of growth patterns, are identified. We report the clinical, radiologic,
and pathologic findings of a rare case of intraoral SFT which exhibited a predominant leiomyomatous-like appearance, closely reminiscent of a leiomyoma, at both incisional and excisional biopsy.
Histologically, the tumor was composed predominantly of intersecting fascicles of eosinophilic spindle-shaped cells, variably set in a fibrous stroma. A focal hemangiopericytoma-like growth pattern with
alternating hypercellular and hypocellular areas, as well as the deposition of dense keloid-type collagen,
raising the suspicion of SFT, could be identified only after a careful examination of the whole tumor.
Immunohistochemistry was helpful in confirming the diagnosis of SFT, revealing a diffuse staining of
neoplastic cells for vimentin, CD34, bcl-2 protein, and, focally, CD99. Myogenic markers (a-smooth
muscle actin, desmin, h-caldesmon) were not expressed.
The pathologist should be aware of this variant of intraoral leiomyomatous-like SFT to avoid a
misdiagnosis of leiomyoma. The distinction of SFT from leiomyoma in the oral cavity is important to
assure both correct treatment and prognostic information
Squamous cell carcinoma arising from long-term (50-year) Lupus vulgaris: is there a need for a close medical follow-up in such chronic diseases?
Paleopathologic study of four nineteenth-century mummies from Goriano Valli (L'Aquila, Italy)
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