38 research outputs found
Direct electrochemical hydrodefluorination of trifluoromethylketones enabled by non-protic conditions
Organotrifluoroborate Hydrolysis: Boronic Acid Release Mechanism and an AcidâBase Paradox in Cross-Coupling
Electronically Ambivalent Hydrodefluorination of Aryl-CF3 groups enabled by Electrochemical Deep-Reduction on a Ni Cathode
Electrochemical Vicinal Difluorination of Alkenes:Scalable and Amenable to Electron-Rich Substrates
Electrochemical Benzylic C(sp3)âH Acyloxylation
[Image: see text] The development of sustainable C(sp(3))âH functionalization methods is of great interest to the pharmaceutical and agrochemical industries. Anodic oxidation is an efficient means of producing benzylic cations that can undergo subsequent in situ nucleophilic attack to afford functionalized benzylic products. Herein, we demonstrate the suitability of carboxylic acids as nucleophiles to yield benzylic esters. This method employs a series of secondary benzylic substrates and functionalized carboxylic acids and is demonstrated on a gram scale in flow